TUG-1609 

TUG-1609 is a fluorescent tracer targeting free fatty acid receptor 2 (FFA2/GPR43) with a K_d value of 65.1 nM^[1].

TUG-1609 acts as an antagonist of human FFA2 in Flp-In™ T-REx™ 293 cells expressing hFFA2-eYFP, inhibiting propionate-mediated IP1 accumulation with a pIC₅₀ of 6.57^[1].
TUG-1609 (2 h) binds to human FFA2 in membrane preparations from Flp-In™ T-REx™ 293 cells expressing hFFA2-eYFP, displacing [³H]-1 with a pK_i of 7.31^[1].
TUG-1609 (0-500 nM; 2 h) binds to NLuc-tagged human FFA2 in membrane preparations from Flp-In™ T-REx™ 293 cells with a K_d of 65.1 nM, a koff of 0.0249 min^-1, and a kon of 368,000 M^-1min^-1[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

751.77

C₃₆H₃₆F₃N₇O₆S

2101952-37-6

O=C(CCCN(CC1=CC=C(C(F)(F)F)C=C1)C(C2(C)N(CC2)C(CC3=CSC4=C3C=CC=C4)=O)=O)NCCCNC5=CC=C([N+]([O-])=O)C6=NON=C65

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Hansen AH, et al. Development and Characterization of a Fluorescent Tracer for the Free Fatty Acid Receptor 2 (FFA2/GPR43). J Med Chem. 2017;60(13):5638-5645.  [Content Brief]