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hepatoprotective+agent

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By Targets:	Aminotransferases (Transaminases) (1) Apoptosis (2) Aryl Hydrocarbon Receptor (2) Biochemical Assay Reagents (1) DNA/RNA Synthesis (1) HBV (1) IFNAR (1) JAK (1) NADPH Oxidase (1) Phosphatase (1) Reference Standards (1) STAT (1)
By Research Areas:	Infection (2) Inflammation/Immunology (3) Metabolic Disease (5)

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Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-128854

Dimethyl biphenyl-4,4'-dicarboxylate 1 Publications Verification	Biochemical Assay Reagents JAK STAT IFNAR DNA/RNA Synthesis HBV	Infection Metabolic Disease
Dimethyl biphenyl-4,4'-dicarboxylate (Biphenyl dimethyl dicarboxylate) is a hepatoprotective agent. Dimethyl biphenyl-4,4'-dicarboxylate stimulates the Jak/Stat signaling pathway and induces the expression of IFN-α-stimulated genes, particularly 6-16 and ISG12. Dimethyl biphenyl-4,4'-dicarboxylate inhibits the replication of pregenomic RNA and HBeAg. Polymer micelles loaded with Dimethyl biphenyl-4,4'-dicarboxylate can serve as carriers for the compound. Dimethyl biphenyl-4,4'-dicarboxylate can be used as an auxiliary improving agent for chronic hepatitis. Dimethyl biphenyl-4,4'-dicarboxylate is applicable to research related to chronic hepatitis B .\n

HY-N1521

Rehmannic acid Lantadene A	Others	Inflammation/Immunology
Rehmannic acid (lantadene A) is a compound isolated from Lantana camara. Rehmannic acid shows considerable in vitro antioxidant, free radical scavenging capacity activities in a dose dependant manner. Rehmannic acid is a promising candidate for use as an antioxidant and hepatoprotective agent .

HY-W024241

Tidiacic	Others	Others
Tidiacic is a hepatoprotective agent that acts as an antioxidant and a sulfur donor .

HY-100242

Mivotilate 3 Publications Verification YH439	Aryl Hydrocarbon Receptor	Others
Mivotilate is a nontoxic, potent activator of the aryl hydrocarbon receptor (AhR), and acts as a hepatoprotective agent.

HY-W027126

Hepatoprotective agent-2	Apoptosis	Metabolic Disease
Hepatoprotective agent-2 (compound 2a), a 4-phenyl-tetrahydroquinoline derivative, displays a remarkable hepatoprotective effect. Hepatoprotective agent-2 has antiapoptotic activity. Hepatoprotective agent-2 notably prevents the chemically induced elevation of hepatic indicators associated with liver injury .

HY-162137

Hepatoprotective agent-1	Apoptosis	Inflammation/Immunology
Hepatoprotective agent-1 (compound 1b) is a hepatoprotective agenrt. Hepatoprotective agent-1 shows anti-inflammatory, antiapoptotic and antifibrotic effects .

HY-N11660

*weak Hepatoprotective agent-1*	Others	Metabolic Disease
weak Hepatoprotective agent-1 (Compound 11) is a natural product that can be isolated from the fruits of Arctium lappa L.. weak Hepatoprotective agent-1 exhibits weak hepatoprotective activities at a concentration of 10 μM .

HY-100242R

Mivotilate (Standard) YH439 (Standard)	Reference Standards Aryl Hydrocarbon Receptor	Others
Mivotilate (Standard) is the analytical standard of Mivotilate. This product is intended for research and analytical applications. Mivotilate is a nontoxic, potent activator of the aryl hydrocarbon receptor (AhR), and acts as a hepatoprotective agent.

HY-106417

Limazocic SA 3443	Phosphatase Aminotransferases (Transaminases)	Metabolic Disease
Limazocic (SA 3443) is an orally active hepatoprotective agent. Limazocic can inhibit increases in serum transaminase, alkaline phosphatase activity and hepatic lipids, hydroxyproline content induced by CCl4. Limazocic can decrease the degree of hepatic necrosis, fibrosis and steatosis. Limazocic can be used for the research of chronic liver injuries .

HY-N18744

Eclipta alba extract	Others	Inflammation/Immunology
Eclipta alba extract is a versatile plant extract derived from the whole plant of Wedelia candel. It is rich in various bioactive compounds, such as eclipta lactone, wedelia saponins, ursolic acid, oleanolic acid, luteolin, and apigenin. Eclipta alba extract is a potent hepatoprotective agent, helping to improve liver function and protect the liver from damage.

HY-N17375

Saikosaponin bk1	NADPH Oxidase	Infection Metabolic Disease
Saikosaponin bk1 is a NADPH-oxidase 5(NOX5) dehydrogenase domain binder and hepatoprotective agent. Saikosaponin bk1 forms stable interactions with the dehydrogenase domain of NOX5 from Cylindrospermum stagnale. Saikosaponin bk1 is applicable to research related to COVID-19 and alcoholic liver injury .

Rehmannic acid Lantadene A	Triterpenes Classification of Application Fields Terpenoids Verbenaceae Plants Disease Research Fields Inflammation/Immunology Source Classification Lantana camaraLinn.	Others
Rehmannic acid (lantadene A) is a compound isolated from Lantana camara. Rehmannic acid shows considerable in vitro antioxidant, free radical scavenging capacity activities in a dose dependant manner. Rehmannic acid is a promising candidate for use as an antioxidant and hepatoprotective agent .

*weak Hepatoprotective agent-1*	Lignans Phenylpropanoids Plants Compositae Source Classification Gueldenstaedtia verna (Georgi) Boriss.	Others
weak Hepatoprotective agent-1 (Compound 11) is a natural product that can be isolated from the fruits of Arctium lappa L.. weak Hepatoprotective agent-1 exhibits weak hepatoprotective activities at a concentration of 10 μM .

Eclipta alba extract	Structural Classification Extract	Others
Eclipta alba extract is a versatile plant extract derived from the whole plant of Wedelia candel. It is rich in various bioactive compounds, such as eclipta lactone, wedelia saponins, ursolic acid, oleanolic acid, luteolin, and apigenin. Eclipta alba extract is a potent hepatoprotective agent, helping to improve liver function and protect the liver from damage.

Saikosaponin bk1	Structural Classification Polysaccharides Terpenoids Apiaceae Bupleurum kunmingense Yin Li & S. L. Pan Plants Pentacyclic Triterpenoids Saccharides Source Classification	NADPH Oxidase
Saikosaponin bk1 is a NADPH-oxidase 5(NOX5) dehydrogenase domain binder and hepatoprotective agent. Saikosaponin bk1 forms stable interactions with the dehydrogenase domain of NOX5 from Cylindrospermum stagnale. Saikosaponin bk1 is applicable to research related to COVID-19 and alcoholic liver injury .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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hepatoprotective+agent

Inhibitors & Agonists

NaturalProducts

Natural
Products