Saikosaponin bk1
Saikosaponin bk1 is a NADPH-oxidase 5(NOX5) dehydrogenase domain binder and hepatoprotective agent. Saikosaponin bk1 forms stable interactions with the dehydrogenase domain of NOX5 from Cylindrospermum stagnale. Saikosaponin bk1 is applicable to research related to COVID-19 and alcoholic liver injury.
For research use only. We do not sell to patients.
- CAS No.: 110352-77-7
- Formula: C48H78O17
- Molecular Weight:927.12
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Saikosaponin bk1 binds to the dehydrogenase domain of Cylindrospermum stagnale NOX5 with a docking score of −7.813 kcal/mol, forming hydrogen bonds with key active site residues[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 110352-77-7
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Molecular Weight 927.12
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Formula C48H78O17
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SMILES
C[C@]12C(C=C[C@@]3([H])[C@]2(CC[C@]4([H])[C@@]3(CC[C@@H](C4(C)C)O[C@@H]5O[C@@H]([C@H]([C@@H]([C@H]5O)O)O[C@H]6[C@@H]([C@@H]([C@H]([C@@H](O6)C)O)O)O)CO[C@@H]7O[C@@H]([C@H]([C@@H]([C@H]7O)O)O)CO)C)C)=C8[C@@]([C@@H](C1)O)(CCC(C)(C8)C)CO
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Chikhale R, et al. Computational assessment of saikosaponins as adjuvant treatment for COVID-19: molecular docking, dynamics, and network pharmacology analysis. Mol Divers. 2021;25(3):1889-1904. [Content Brief]
[2]. Khan A, et al. Investigation of the Hepatoprotective Effect of Prunus mume Sieb. et Zucc Extract in a Mouse Model of Alcoholic Liver Injury Through High-Resolution Metabolomics. J Med Food. 2017;20(8):734-743. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Saikosaponin bk1 Related Classifications
HY-N17375 Related Classifications
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- Saikosaponin bk1
- 110352-77-7
- Saikosaponin bk 1
- Saikosaponin bk-1
- NADPH Oxidase
- Cylindrospermum stagnale NOX5
- NOX5 dehydrogenase domain
- Cylindrospermum stagnale NADPH-oxidase 5
- apoptosis pathways
- Prunus mume Sieb. et Zucc
- oxidative stress
- inflammation
- COVID-19
- mice
- alcohol-induced liver injury
- Inhibitor
- inhibitor
- inhibit