2. Others Protein Tyrosine Kinase/RTK JAK/STAT Signaling Epigenetics Stem Cell/Wnt Immunology/Inflammation Cell Cycle/DNA Damage Anti-infection
  3. Biochemical Assay Reagents JAK STAT IFNAR DNA/RNA Synthesis HBV
  4. Dimethyl biphenyl-4,4'-dicarboxylate

Dimethyl biphenyl-4,4'-dicarboxylate (Biphenyl dimethyl dicarboxylate) is a hepatoprotective agent. Dimethyl biphenyl-4,4'-dicarboxylate stimulates the Jak/Stat signaling pathway and induces the expression of IFN-α-stimulated genes, particularly 6-16 and ISG12. Dimethyl biphenyl-4,4'-dicarboxylate inhibits the replication of pregenomic RNA and HBeAg. Polymer micelles loaded with Dimethyl biphenyl-4,4'-dicarboxylate can serve as carriers for the compound. Dimethyl biphenyl-4,4'-dicarboxylate can be used as an auxiliary improving agent for chronic hepatitis. Dimethyl biphenyl-4,4'-dicarboxylate is applicable to research related to chronic hepatitis B.\n



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Dimethyl biphenyl-4,4'-dicarboxylate

Dimethyl biphenyl-4,4'-dicarboxylate Chemical Structure

CAS No. : 792-74-5

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Based on 1 publication(s) in Google Scholar

Other Forms of Dimethyl biphenyl-4,4'-dicarboxylate:

Dimethyl biphenyl-4,4'-dicarboxylate Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Dimethyl biphenyl-4,4'-dicarboxylate

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RNASE L DNA Polymerases RNA Polymerases Helicases DNA Ligase

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Description

Dimethyl biphenyl-4,4'-dicarboxylate (Biphenyl dimethyl dicarboxylate) is a hepatoprotective agent. Dimethyl biphenyl-4,4'-dicarboxylate stimulates the Jak/Stat signaling pathway and induces the expression of IFN-α-stimulated genes, particularly 6-16 and ISG12. Dimethyl biphenyl-4,4'-dicarboxylate inhibits the replication of pregenomic RNA and HBeAg. Polymer micelles loaded with Dimethyl biphenyl-4,4'-dicarboxylate can serve as carriers for the compound. Dimethyl biphenyl-4,4'-dicarboxylate can be used as an auxiliary improving agent for chronic hepatitis. Dimethyl biphenyl-4,4'-dicarboxylate is applicable to research related to chronic hepatitis B[1][2].\n
In Vitro

Dimethyl biphenyl-4,4'-dicarboxylate (31.25-500 μg/mL; 24 h) exhibits cytotoxicity against HepG2 2.2.15 cells at concentrations exceeding 500 μg/mL[1].
Dimethyl biphenyl-4,4'-dicarboxylate (250 μg/mL; 5 days) strongly induces the expression of two interferon-stimulated genes, 6-16 and ISG12, in HepG2 2.2.15 cells, with the induction level of 6-16 comparable to that of IFN-α[1].
Dimethyl biphenyl-4,4'-dicarboxylate (250 μg/mL; 5 days) induces the expression of antiviral effector genes PKR and OAS in HepG2 2.2.15 cells[1].
Dimethyl biphenyl-4,4'-dicarboxylate (30-300 μg/mL; 5-7 days) dose-dependently inhibits the expression of HBV pregenomic RNA in HepG2 2.2.15 cells, and the inhibitory effect is strong at the concentration of 300 μg/mL after 7 days of incubation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Dimethyl biphenyl-4,4'-dicarboxylate Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: HepG2 2.2.15 human hepatoblastoma cells stably transfected with genomic HBV DNA
Concentration: 250 μg/mL (non-cytotoxic dose); 500 μg/mL (cytotoxic dose)
Incubation Time: 24 h
Result: Exhibited cytotoxicity at concentrations over 500 μg/mL.
Showed reduced cytotoxicity at 250 μg/mL.
Matched control LDH levels at 250 μg/mL, identifying this as an effective, non-cytotoxic concentration.

Western Blot Analysis[1]

Cell Line: HepG2 2.2.15 cells
Concentration: 250 μg/mL
Incubation Time: 5 days
Result: Regulated the IFN-induced Jak/Stat pathway to a degree commensurate with that of IFN-α.
Molecular Weight

270.28

Formula

C16H14O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

COC(C1=CC=C(C2=CC=C(C(OC)=O)C=C2)C=C1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMF : 2 mg/mL (7.40 mM; Need ultrasonic)

DMSO : 2 mg/mL (7.40 mM; ultrasonic and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.6999 mL 18.4993 mL 36.9987 mL
5 mM 0.7400 mL 3.6999 mL 7.3997 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.85%

SDS (394 KB)

COA (247 KB) HNMR (115 KB) RP-HPLC (258 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMF / DMSO 1 mM 3.6999 mL 18.4993 mL 36.9987 mL 92.4967 mL
5 mM 0.7400 mL 3.6999 mL 7.3997 mL 18.4993 mL
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Dimethyl biphenyl-4,4'-dicarboxylate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dimethyl biphenyl-4,4'-dicarboxylate792-74-5Biochemical Assay ReagentsJAKSTATIFNARDNA/RNA SynthesisHBVJanus kinaseInterferon-α/β receptorInterferon-alpha/beta receptor Hepatitis B virusJak/Stat pathwayHBV pregenomic RNAinterferon signalinginterferon-inducible genesPKRMxAHepG2 2.2.15 cellsOASIFNAR mRNAISG12Inhibitorinhibitorinhibit

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