Dimethyl biphenyl-4,4'-dicarboxylate
Based on 1 publication(s) in Google Scholar
Dimethyl biphenyl-4,4'-dicarboxylate (Biphenyl dimethyl dicarboxylate) is a hepatoprotective agent. Dimethyl biphenyl-4,4'-dicarboxylate stimulates the Jak/Stat signaling pathway and induces the expression of IFN-α-stimulated genes, particularly 6-16 and ISG12. Dimethyl biphenyl-4,4'-dicarboxylate inhibits the replication of pregenomic RNA and HBeAg. Polymer micelles loaded with Dimethyl biphenyl-4,4'-dicarboxylate can serve as carriers for the compound. Dimethyl biphenyl-4,4'-dicarboxylate can be used as an auxiliary improving agent for chronic hepatitis. Dimethyl biphenyl-4,4'-dicarboxylate is applicable to research related to chronic hepatitis B.
For research use only. We do not sell to patients.
- Purity: 99.85%
- CAS No.: 792-74-5
- Formula: C16H14O4
- Molecular Weight:270.28
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Dimethyl biphenyl-4,4'-dicarboxylate
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Biological Activity
Dimethyl biphenyl-4,4'-dicarboxylate (31.25-500 μg/mL; 24 h) exhibits cytotoxicity against HepG2 2.2.15 cells at concentrations exceeding 500 μg/mL[1].
Dimethyl biphenyl-4,4'-dicarboxylate (250 μg/mL; 5 days) strongly induces the expression of two interferon-stimulated genes, 6-16 and ISG12, in HepG2 2.2.15 cells, with the induction level of 6-16 comparable to that of IFN-α[1].
Dimethyl biphenyl-4,4'-dicarboxylate (250 μg/mL; 5 days) induces the expression of antiviral effector genes PKR and OAS in HepG2 2.2.15 cells[1].
Dimethyl biphenyl-4,4'-dicarboxylate (30-300 μg/mL; 5-7 days) dose-dependently inhibits the expression of HBV pregenomic RNA in HepG2 2.2.15 cells, and the inhibitory effect is strong at the concentration of 300 μg/mL after 7 days of incubation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HepG2 2.2.15 human hepatoblastoma cells stably transfected with genomic HBV DNA
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Concentration:250 μg/mL (non-cytotoxic dose); 500 μg/mL (cytotoxic dose)
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Incubation Time:24 h
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Result:Exhibited cytotoxicity at concentrations over 500 μg/mL.
Showed reduced cytotoxicity at 250 μg/mL.
Matched control LDH levels at 250 μg/mL, identifying this as an effective, non-cytotoxic concentration.
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Cell Line:HepG2 2.2.15 cells
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Concentration:250 μg/mL
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Incubation Time:5 days
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Result:Regulated the IFN-induced Jak/Stat pathway to a degree commensurate with that of IFN-α.
Chemical Information
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CAS No. 792-74-5
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Appearance Solid
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Molecular Weight 270.28
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Formula C16H14O4
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Color White to off-white
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SMILES
COC(C1=CC=C(C2=CC=C(C(OC)=O)C=C2)C=C1)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (1)
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Journal Impact Factor
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Most Recent
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Phys Chem Chem Phys
Why does the presence of silicon atoms improve the emission properties of biphenyl derivatives? - Verification of various hypotheses by experiment and theory. [Abstract]2019 Sep 18;21(36):20384-20392. PMID: 31498339
Solvent & Solubility
DMF : 2 mg/mL (7.40 mM; Need ultrasonic)
DMSO : 2 mg/mL (7.40 mM; ultrasonic and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
[1]. Joo SS, et al. Interferon signal transduction of biphenyl dimethyl dicarboxylate/amantadine and anti-HBV activity in HepG2 2.2.15. Arch Pharm Res. 2006;29(5):405-411. [Content Brief]
[2]. Chi SC, et al. A polymeric micellar carrier for the solubilization of biphenyl dimethyl dicarboxylate. Arch Pharm Res. 2003;26(2):173-181. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMF / DMSO | 1 mM | 3.6999 mL | 18.4993 mL | 36.9987 mL | 92.4967 mL |
| 5 mM | 0.7400 mL | 3.6999 mL | 7.3997 mL | 18.4993 mL |
Dimethyl biphenyl-4,4'-dicarboxylate Related Classifications
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