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Results for "

luteinizing hormone receptor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	GnRH Receptor (18) TSH Receptor (2) Endogenous Metabolite (3) Environmental Pollutants (1) Estrogen Receptor/ERR (5) Ferroptosis (3) GABA Receptor (1) Isotope-Labeled Compounds (2) Kisspeptin Receptor (1) MDM-2/p53 (3) Neurokinin Receptor (2) PDI (3) PERK (1) Prostaglandin Receptor (3) Ras (1) Reactive Oxygen Species (ROS) (3) Reference Standards (2) Sirtuin (3)
By Research Areas:	Cancer (8) Endocrinology (25) Inflammation/Immunology (1) Metabolic Disease (3) Neurological Disease (4)

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Targets Recommended: Thyroid Hormone Receptor PTHR GHR Nuclear Hormone Receptor 4A/NR4A TSH Receptor MCHR1 (GPR24) GHSR Hormone-Sensitive Lipase (HSL) GnRH Receptor

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-130248

BAY-899 1 Publications Verification	GnRH Receptor	Endocrinology
BAY-899, a chemical probe, is an orally active and selective luteinizing hormone receptor (LH-R) antagonist with IC₅₀s of 185 nM and 46nM for hLH (human LH) and rLH (rat LH), respectively. BAY-899 can reduce sex hormone levels .

HY-100209

Sufugolix TAK-013	GnRH Receptor	Endocrinology
Sufugolix (TAK-013) is a highly potent and orally available luteinizing hormone-releasing hormone (LHRH) receptor antagonist with an IC₅₀ of 0.1 nM.

HY-P3668

[D-Lys6]-LH-RH	GnRH Receptor	Endocrinology Cancer
[D-Lys6]-LH-RH is a Luteinizing-hormone-releasing hormone (LHRH) analogue. [D-Lys6]-LH-RH acts as a GnRH receptor agonist .

HY-130249

BAY-298	GnRH Receptor	Endocrinology
BAY-298 is an orally active and selective luteinizing hormone receptor (LH-R) antagonist with IC₅₀s of 96 nM, 23 nM and 78 nM for hLH (human LH) and rLH (rat LH) and cLH (cynomolgus monkey LH), respectively. BAY-298 can reduce sex hormone levels .

HY-19464

Org 43553	GnRH Receptor Estrogen Receptor/ERR	Endocrinology
Org 43553 is an orally active and low molecular weight (LMW) luteinizing hormone receptor (LH-R) agonist. Org 43553 shows agonistic activity to human LH and FSH receptors with EC₅₀ values of 3.7 and 110 nM, respectively. Org 43553 can be used for the research of endocrine .

HY-100812

2-Hydroxysaclofen	GABA Receptor	Neurological Disease Endocrinology
2-Hydroxysaclofen is a potent γ-amino-butyric-acid-B (GABA_B) receptor antagonist. 2-Hydroxysaclofen can abolish nicotine-induced hypolocomotor effects and increases the antinociceptive effects. 2-Hydroxysaclofen can stimulate luteinizing hormone (LH) secretion in female rats .

HY-W041308

DCOIT Kathon 930	Environmental Pollutants GnRH Receptor	Endocrinology
DCOIT is a representative isothiazolinone that stimulates the gonadotropin-releasing hormone receptor (GnRHR)-mediated synthesis of follicle-stimulating hormone and luteinizing hormone in the brain. DCOIT interferes with G protein-coupled receptors, MAPK and Ca ²⁺ signaling cascades .

HY-100271

Org41841	TSH Receptor	Endocrinology
Org41841 is a partial agonist of both luteinizing hormone/chorionic gonadotropin receptor (LHCGR) and thyroid-stimulating hormone receptor (TSHR) with EC₅₀s of 0.2 and 7.7 μM, respectively.

HY-164764

ADX61623	Estrogen Receptor/ERR	Endocrinology
ADX61623 is a potent *follicle stimulating hormone* (FSH) receptor (FSHR)** negative allosteric modulator (NAM). ADX61623 shows luteinizing hormone receptor (LH-R) activity and is not active on thyroid-stimulating hormone (TSH) receptors. ADX61623 can be used for the study of estrogen dependent disease .

HY-W009300

4-Hydroxyestrone 1 Publications Verification 4-OHE1	Endogenous Metabolite Estrogen Receptor/ERR Sirtuin MDM-2/p53 PDI Ferroptosis Reactive Oxygen Species (ROS)	Neurological Disease Metabolic Disease Cancer
4-Hydroxyestrone (4-OHE1) is a brain-penetrant estrogen metabolite. 4-Hydroxyestrone shows neuroprotective effects involving increased cytoplasmic localization of p53 resulting from SIRT1-mediated p53 deacetylation. 4-Hydroxyestrone relies on PDI to mediate its protective effect against chemically induced ferroptosis in estrogen receptor-negative cancer cells. 4-Hydroxyestrone inhibits lipid peroxidation and lipid-ROS accumulation. 4-Hydroxyestrone blocks preovulatory luteinizing hormone surges in Rattus norvegicus. 4-Hydroxyestrone can be used for the researches of neurodegeneration, breast cancer and endocrine disease .

HY-P3668A

[D-Lys6]-LH-RH TFA	GnRH Receptor	Endocrinology Cancer
[D-Lys6]-LH-RH TFA is a Luteinizing-hormone-releasing hormone (LHRH) analogue. [D-Lys6]-LH-RH TFA acts as a GnRH receptor agonist .

HY-139303

LUF5771	GnRH Receptor	Endocrinology
LUF5771 is a potent allosteric recombinant luteinizing hormone (recLH) and Org 43553 inhibitor. LUF5771 is able to partially activate the LH receptor with low efficacy .

HY-13699

NBI-42902	GnRH Receptor PERK	Others
NBI-42902 is an orally active, potent functional and competitive antagonist of GnRH receptor with an IC₅₀ value of 0.79 nM, a K_i value of 0.56 nM, respectively. NBI-42902 inhibits GnRH-stimulated inositol phosphate (IP) accumulation, Ca ²⁺ flux, and ERK1/2 activation. NBI-42902 inhibits serum luteinizing hormone (LH) in castrated male macaques. NBI-42902 can be used for research on sex-hormone-related diseases .

HY-130660

Prostaglandin F2α ethanolamide Prostamide F2α	Prostaglandin Receptor	Endocrinology
Prostaglandin F2α ethanolamide (Prostamide F2α) is an ethanolamide-like G protein-coupled receptor. Prostaglandin F2α is also a luteinizing hormone in sheep and may be a nociceptive mediator in the spinal cord .

HY-130248B

(R)-BAY-899	GnRH Receptor	Others
(R)-BAY-899 is the R-enantiomer of BAY-899. BAY-899 is an orally active and selective luteinizing hormone receptor (LH-R) antagonist with IC50s of 185 nM and 46nM for hLH (human LH) and rLH (rat LH), respectively .

HY-144863

BAY 1214784	GnRH Receptor	Cancer
BAY 1214784 is a potent, selective, and orally active antagonist of the human gonadotropin-releasing hormone receptor (hGnRH-R). BAY 1214784 is a spiroindoline derivative compound. BAY 1214784 effectively lowers plasma luteinizing hormone levels by up to 49%, at the same time being associated with low pharmacokinetic variability and good tolerability. BAY 1214784 has the potential for the research of uterine fibroids .

HY-114810

Prostaglandin F2α serinol amide	Prostaglandin Receptor	Endocrinology
Prostaglandin F2α serinol amide is a serinolamide G protein-coupled receptor that increases calcium levels in human non-small cell lung cancer cells. Prostaglandin F2α is also a luteinizing hormone in sheep and may be a nociceptive mediator in the spinal cord .

HY-W041308R

DCOIT (Standard) Kathon 930 (Standard)	GnRH Receptor Reference Standards	Endocrinology
DCOIT (Standard) is the analytical standard of DCOIT. This product is intended for research and analytical applications. DCOIT is a representative isothiazolinone that stimulates the gonadotropin-releasing hormone receptor (GnRHR)-mediated synthesis of follicle-stimulating hormone and luteinizing hormone in the brain. DCOIT interferes with G protein-coupled receptors, MAPK and Ca2+ signaling cascades[1].

HY-120767

Linzagolix choline KLH-2109 choline; OBE-2109 choline	GnRH Receptor	Inflammation/Immunology Cancer
Linzagolix choline (KLH-2109 choline) is a non-peptide gonadotropin-releasing hormone (GnRH) antagonist with oral activity. Linzagolix choline inhibits the release of endogenous gonadotropins such as luteinizing hormone LH and follicle-stimulating hormone FSH by binding to the GnRH receptor within the pituitary gland. This inhibition results in a reduction in the production of sex hormones such as estrogen and progesterone, which in turn affects the course of sex hormone-dependent diseases. Linzagolix choline can be used in the study of sex hormone-dependent diseases such as endometriosis and uterine fibroids .

HY-P2110

RS-18286	GnRH Receptor	Endocrinology
RS-18286 is a potent luteinizing-hormone (LH)-releasing hormone (LHRH) antagonist. RS-18286 blocks the pituitary LHRH receptor and suppresses pituitary luteinizing-hormone (LH) secretion and reduce serum concentrations of gonadal steroids .

HY-107533

T-98475	GnRH Receptor	Endocrinology
T-98475 (Compound 26d) is a potent, orally active, non-peptide **luteinizing hormone-releasing hormone (LHRH) receptor antagonist with an IC₅₀** of 0.2 nM .

HY-P3672

[D-Ala6]-LH-RH	GnRH Receptor	Endocrinology
[D-Ala6]-LH-RH is a Luteinizing-hormone-releasing hormone (LHRH) analogue. [D-Ala6]-LH-RH acts as a GnRH receptor agonist .

HY-117061

Prostaglandin F2α alcohol methyl ether	Prostaglandin Receptor	Endocrinology
Prostaglandin F2α alcohol methyl ether is an alcohol methyl ether G protein-coupled receptor. Prostaglandin F2α is also a luteinizing hormone in sheep and may be a nociceptive mediator in the spinal cord .

HY-P3671

[D-Glp1,D-Phe2,D-Trp3,6]-LH-RH	GnRH Receptor	Endocrinology
[D-Glp1,D-Phe2,D-Trp3,6]-LH-RH is a Luteinizing-hormone-releasing hormone (LHRH) analogue. [D-Glp1,D-Phe2,D-Trp3,6]-LH-RH acts as a GnRH receptor antagonist .

HY-P10594

Myr-Arf1(2–17)	Ras	Endocrinology
Myr-Arf1(2–17) is a sarcosinated peptide that mimics the localization and function of Arf1 protein on the cell membrane. Myr-Arf1(2–17) can be used to study the desensitization mechanism of luteinizing hormone/chorionic gonadotropin receptor (LH/CGR) .

HY-149358

NK3R-IN-1	Neurokinin Receptor	Endocrinology
NK3R-IN-1 (compound 16x), a imidazolepiperazine derivative, is an orally active Neurokinin Receptor NK3R inhibitor. NK3R-IN-1 decreases blood luteinizing hormone levels in ovariectomy (OVX) model .

HY-W009300S

4-Hydroxyestrone-d4 4-OHE1-d₄	Endogenous Metabolite Isotope-Labeled Compounds Estrogen Receptor/ERR Sirtuin MDM-2/p53 PDI Ferroptosis Reactive Oxygen Species (ROS)	Neurological Disease Metabolic Disease Cancer
4-Hydroxyestrone (4-OHE1)-d₄ is the deuterium labeled 4-Hydroxyestrone (HY-W009300). 4-Hydroxyestrone is a brain-penetrant estrogen metabolite. 4-Hydroxyestrone shows neuroprotective effects involving increased cytoplasmic localization of p53 resulting from SIRT1-mediated p53 deacetylation. 4-Hydroxyestrone relies on PDI to mediate its protective effect against chemically induced ferroptosis in estrogen receptor-negative cancer cells. 4-Hydroxyestrone inhibits lipid peroxidation and lipid-ROS accumulation. 4-Hydroxyestrone blocks preovulatory luteinizing hormone surges in Rattus norvegicus. 4-Hydroxyestrone can be used for the researches of neurodegeneration, breast cancer and endocrine disease .

HY-W009300S1

4-Hydroxyestrone-13C6 4-OHE1-¹³C₆	Isotope-Labeled Compounds Endogenous Metabolite Estrogen Receptor/ERR Sirtuin MDM-2/p53 PDI Ferroptosis Reactive Oxygen Species (ROS)	Neurological Disease Metabolic Disease Cancer
4-Hydroxyestrone (4-OHE1)- ¹³C₆ is a ¹³C-labeled 4-Hydroxyestrone (HY-W009300). 4-Hydroxyestrone is a brain-penetrant estrogen metabolite. 4-Hydroxyestrone shows neuroprotective effects involving increased cytoplasmic localization of p53 resulting from SIRT1-mediated p53 deacetylation. 4-Hydroxyestrone relies on PDI to mediate its protective effect against chemically induced ferroptosis in estrogen receptor-negative cancer cells. 4-Hydroxyestrone inhibits lipid peroxidation and lipid-ROS accumulation. 4-Hydroxyestrone blocks preovulatory luteinizing hormone surges in Rattus norvegicus. 4-Hydroxyestrone can be used for the researches of neurodegeneration, breast cancer and endocrine disease .

HY-181682

NK3R antagonist-1	Neurokinin Receptor	Endocrinology
NK3R antagonist-1 is an orally active neurokinin-3 receptor (NK3R) antagonist with an IC₅₀ of 53.61 nM. NK3R antagonist-1 reduces plasma luteinizing hormone (LH) levels in ovariectomized rat models. NK3R antagonist-1 is applicable to research related to menopausal hot flushes .

HY-100271R

Org41841 (Standard)	TSH Receptor Reference Standards	Endocrinology
Org41841 (Standard) is the analytical standard of Org41841 (HY-100271). This product is intended for research and analytical applications. Org41841 is a partial agonist of both luteinizing hormone/chorionic gonadotropin receptor (LHCGR) and thyroid-stimulating hormone receptor (TSHR) with EC50s of 0.2 and 7.7 μM, respectively.

HY-182421

GPR54 antagonist-1	Kisspeptin Receptor	Endocrinology Cancer
GPR54 antagonist‑1 is a GPR54 antagonist with IC₅₀ values of 3.6 nM and 15 nM against human and rat GPR54, respectively. GPR54 antagonist‑1 shows blood‑brain barrier penetration. GPR54 antagonist‑1 blocks the function of human and rat GPR54 receptors. GPR54 antagonist‑1 suppresses plasma luteinizing hormone levels in castrated male rats. GPR54 antagonist‑1 can be used for the study of prostate cancer and endometriosis .

HY-P992149

Lutropin alfa	GnRH Receptor	Endocrinology
Lutropin alfa is a recombinant human luteinizing hormone (LH). Lutropin alfa consists of non-covalently linked α and β subunits, and its activity is similar to that of natural luteinizing hormone. Lutropin alfa is used to stimulate follicular development in infertility .

Cat. No.	Product Name	Target	Research Area

HY-P3668

[D-Lys6]-LH-RH	GnRH Receptor	Endocrinology Cancer
[D-Lys6]-LH-RH is a Luteinizing-hormone-releasing hormone (LHRH) analogue. [D-Lys6]-LH-RH acts as a GnRH receptor agonist .

HY-P3668A

[D-Lys6]-LH-RH TFA	GnRH Receptor	Endocrinology Cancer
[D-Lys6]-LH-RH TFA is a Luteinizing-hormone-releasing hormone (LHRH) analogue. [D-Lys6]-LH-RH TFA acts as a GnRH receptor agonist .

HY-P2110

RS-18286	GnRH Receptor	Endocrinology
RS-18286 is a potent luteinizing-hormone (LH)-releasing hormone (LHRH) antagonist. RS-18286 blocks the pituitary LHRH receptor and suppresses pituitary luteinizing-hormone (LH) secretion and reduce serum concentrations of gonadal steroids .

HY-P3672

[D-Ala6]-LH-RH	GnRH Receptor	Endocrinology
[D-Ala6]-LH-RH is a Luteinizing-hormone-releasing hormone (LHRH) analogue. [D-Ala6]-LH-RH acts as a GnRH receptor agonist .

HY-P3671

[D-Glp1,D-Phe2,D-Trp3,6]-LH-RH	GnRH Receptor	Endocrinology
[D-Glp1,D-Phe2,D-Trp3,6]-LH-RH is a Luteinizing-hormone-releasing hormone (LHRH) analogue. [D-Glp1,D-Phe2,D-Trp3,6]-LH-RH acts as a GnRH receptor antagonist .

HY-P10594

Myr-Arf1(2–17)	Ras	Endocrinology
Myr-Arf1(2–17) is a sarcosinated peptide that mimics the localization and function of Arf1 protein on the cell membrane. Myr-Arf1(2–17) can be used to study the desensitization mechanism of luteinizing hormone/chorionic gonadotropin receptor (LH/CGR) .

Cat. No.	Product Name	Target	Research Area	Image

HY-P992149

Lutropin alfa	GnRH Receptor	Endocrinology
Lutropin alfa is a recombinant human luteinizing hormone (LH). Lutropin alfa consists of non-covalently linked α and β subunits, and its activity is similar to that of natural luteinizing hormone. Lutropin alfa is used to stimulate follicular development in infertility .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W009300

4-Hydroxyestrone 1 Publications Verification 4-OHE1	Structural Classification Animals Neurological Disease Classification of Application Fields Endogenous metabolite Disease Research Fields Steroids Source Classification	Endogenous Metabolite Estrogen Receptor/ERR Sirtuin MDM-2/p53 PDI Ferroptosis Reactive Oxygen Species (ROS)
4-Hydroxyestrone (4-OHE1) is a brain-penetrant estrogen metabolite. 4-Hydroxyestrone shows neuroprotective effects involving increased cytoplasmic localization of p53 resulting from SIRT1-mediated p53 deacetylation. 4-Hydroxyestrone relies on PDI to mediate its protective effect against chemically induced ferroptosis in estrogen receptor-negative cancer cells. 4-Hydroxyestrone inhibits lipid peroxidation and lipid-ROS accumulation. 4-Hydroxyestrone blocks preovulatory luteinizing hormone surges in Rattus norvegicus. 4-Hydroxyestrone can be used for the researches of neurodegeneration, breast cancer and endocrine disease .

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P705680

	Lhcgr Protein, Rat (His) Lhcgr; Lutropin-choriogonadotropic hormone receptor; LH/CG-R; luteinizing hormone receptor; LSH-R	Rat	E. coli

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HY-W009300S

4-Hydroxyestrone-d4

4-Hydroxyestrone (4-OHE1)-d₄ is the deuterium labeled 4-Hydroxyestrone (HY-W009300). 4-Hydroxyestrone is a brain-penetrant estrogen metabolite. 4-Hydroxyestrone shows neuroprotective effects involving increased cytoplasmic localization of p53 resulting from SIRT1-mediated p53 deacetylation. 4-Hydroxyestrone relies on PDI to mediate its protective effect against chemically induced ferroptosis in estrogen receptor-negative cancer cells. 4-Hydroxyestrone inhibits lipid peroxidation and lipid-ROS accumulation. 4-Hydroxyestrone blocks preovulatory luteinizing hormone surges in Rattus norvegicus. 4-Hydroxyestrone can be used for the researches of neurodegeneration, breast cancer and endocrine disease .

HY-W009300S1

4-Hydroxyestrone-13C6

4-Hydroxyestrone (4-OHE1)- ¹³C₆ is a ¹³C-labeled 4-Hydroxyestrone (HY-W009300). 4-Hydroxyestrone is a brain-penetrant estrogen metabolite. 4-Hydroxyestrone shows neuroprotective effects involving increased cytoplasmic localization of p53 resulting from SIRT1-mediated p53 deacetylation. 4-Hydroxyestrone relies on PDI to mediate its protective effect against chemically induced ferroptosis in estrogen receptor-negative cancer cells. 4-Hydroxyestrone inhibits lipid peroxidation and lipid-ROS accumulation. 4-Hydroxyestrone blocks preovulatory luteinizing hormone surges in Rattus norvegicus. 4-Hydroxyestrone can be used for the researches of neurodegeneration, breast cancer and endocrine disease .

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luteinizing hormone receptor

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