2. GPCR/G Protein
  3. GnRH Receptor
  4. [D-Lys6]-LH-RH

[D-Lys6]-LH-RH is a Luteinizing-hormone-releasing hormone (LHRH) analogue. [D-Lys6]-LH-RH acts as a GnRH receptor agonist.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

[D-Lys6]-LH-RH

[D-Lys6]-LH-RH Chemical Structure

CAS No. : 52671-12-2

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of [D-Lys6]-LH-RH:

[D-Lys6]-LH-RH Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

[D-Lys6]-LH-RH is a Luteinizing-hormone-releasing hormone (LHRH) analogue. [D-Lys6]-LH-RH acts as a GnRH receptor agonist[1].

Cellular Effect
Cell Line Type Value Description References
DU-145 IC50
> 40000 nM
Compound: D-Lys6-GnRH
Antiproliferative activity against human DU145 cells measured after 72 hrs by MTT assay
Antiproliferative activity against human DU145 cells measured after 72 hrs by MTT assay
[PMID: 30716713]
HEK293 IC50
10.5 nM
Compound: D-Lys6-GnRH
Displacement of [125I]-D-Tyr6-His5-GnRH from recombinant human GnRH receptor expressed in HEK293 cell membrane measured after 16 to 19 hrs by gamma counting method
Displacement of [125I]-D-Tyr6-His5-GnRH from recombinant human GnRH receptor expressed in HEK293 cell membrane measured after 16 to 19 hrs by gamma counting method
[PMID: 30716713]
MCF7 IC50
> 40000 nM
Compound: D-Lys6-GnRH
Antiproliferative activity against human MCF7 cells measured after 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells measured after 72 hrs by MTT assay
[PMID: 30716713]
MDA-MB-231 IC50
> 40000 nM
Compound: D-Lys6-GnRH
Antiproliferative activity against human MDA-MB-231 cells measured after 72 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells measured after 72 hrs by MTT assay
[PMID: 30716713]
PC-3 IC50
> 40000 nM
Compound: D-Lys6-GnRH
Antiproliferative activity against human PC3 cells measured after 72 hrs by MTT assay
Antiproliferative activity against human PC3 cells measured after 72 hrs by MTT assay
[PMID: 30716713]
In Vivo

[D-Lys6]-LH-RH (100 μg, minipumps implanted subcutaneously) inhibits tumor growth in Dunning R-3327H prostate cancer rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Dunning R-3327H prostate cancer rats[1]
Dosage: 100 μg
Administration: Alzet minipumps implanted subcutaneously
Result: Inhibited tumor growth compared with control.
Molecular Weight

1253.41

Formula

C59H84N18O13
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

{Glp}-His-Trp-Ser-Tyr-{d-Lys}-Leu-Arg-Pro-Gly-NH2
Sequence Shortening

{Glp}-HWSY-{d-Lys}-LRPG-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (79.78 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.7978 mL 3.9891 mL 7.9782 mL
5 mM 0.1596 mL 0.7978 mL 1.5956 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.85%

SDS (420 KB)

COA (252 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.7978 mL 3.9891 mL 7.9782 mL 19.9456 mL
5 mM 0.1596 mL 0.7978 mL 1.5956 mL 3.9891 mL
10 mM 0.0798 mL 0.3989 mL 0.7978 mL 1.9946 mL
15 mM 0.0532 mL 0.2659 mL 0.5319 mL 1.3297 mL
20 mM 0.0399 mL 0.1995 mL 0.3989 mL 0.9973 mL
25 mM 0.0319 mL 0.1596 mL 0.3191 mL 0.7978 mL
30 mM 0.0266 mL 0.1330 mL 0.2659 mL 0.6649 mL
40 mM 0.0199 mL 0.0997 mL 0.1995 mL 0.4986 mL
50 mM 0.0160 mL 0.0798 mL 0.1596 mL 0.3989 mL
60 mM 0.0133 mL 0.0665 mL 0.1330 mL 0.3324 mL
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[D-Lys6]-LH-RH Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

[D-Lys6]-LH-RH52671-12-2GnRH ReceptorGonadotropin releasing hormone receptorGNRHRLHRHLHRH analogueprostate cancerR-3327HInhibitorinhibitorinhibit

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