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Cat. No.: HY-P3668

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[D-Lys6]-LH-RH

고객리뷰

Based on 1 Customer Validation

[D-Lys6]-LH-RH is a Luteinizing-hormone-releasing hormone (LHRH) analogue. [D-Lys6]-LH-RH acts as a GnRH receptor agonist.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Purity: 99.85%
CAS No.: 52671-12-2
화학식: C₅₉H₈₄N₁₈O₁₃
분자량:1253.41

보관:

Sealed storage, away from moisture.

Powder -80°C, 2 years , -20°C, 1 year

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

[D-Lys6]-LH-RH Chemical Structure

CAS No.: 52671-12-2

사이즈

가격

재고

수량

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
- In Vivo
Chemical Information
용액&용해도
- In Vitro
순도&문서
References
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

[D-Lys6]-LH-RH is a Luteinizing-hormone-releasing hormone (LHRH) analogue. [D-Lys6]-LH-RH acts as a GnRH receptor agonist^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
DU-145	IC₅₀	>40000 nM Compound: D-Lys6-GnRH	Antiproliferative activity against human DU145 cells measured after 72 hrs by MTT assay Antiproliferative activity against human DU145 cells measured after 72 hrs by MTT assay	[PMID: 30716713]
HEK293	IC₅₀	10.5 nM Compound: D-Lys6-GnRH	Displacement of [125I]-D-Tyr6-His5-GnRH from recombinant human GnRH receptor expressed in HEK293 cell membrane measured after 16 to 19 hrs by gamma counting method Displacement of [125I]-D-Tyr6-His5-GnRH from recombinant human GnRH receptor expressed in HEK293 cell membrane measured after 16 to 19 hrs by gamma counting method	[PMID: 30716713]
MCF7	IC₅₀	>40000 nM Compound: D-Lys6-GnRH	Antiproliferative activity against human MCF7 cells measured after 72 hrs by MTT assay Antiproliferative activity against human MCF7 cells measured after 72 hrs by MTT assay	[PMID: 30716713]
MDA-MB-231	IC₅₀	>40000 nM Compound: D-Lys6-GnRH	Antiproliferative activity against human MDA-MB-231 cells measured after 72 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells measured after 72 hrs by MTT assay	[PMID: 30716713]
PC-3	IC₅₀	>40000 nM Compound: D-Lys6-GnRH	Antiproliferative activity against human PC3 cells measured after 72 hrs by MTT assay Antiproliferative activity against human PC3 cells measured after 72 hrs by MTT assay	[PMID: 30716713]

In Vivo

[D-Lys6]-LH-RH (100 μg, minipumps implanted subcutaneously) inhibits tumor growth in Dunning R-3327H prostate cancer rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Dunning R-3327H prostate cancer rats^[1]
Dosage:

100 μg
Administration:

Alzet minipumps implanted subcutaneously
Result:

Inhibited tumor growth compared with control.

Chemical Information

CAS No. 52671-12-2
Appearance Solid
분자량 1253.41
화학식 C₅₉H₈₄N₁₈O₁₃
Color White to off-white
Sequence

{Glp}-His-Trp-Ser-Tyr-{d-Lys}-Leu-Arg-Pro-Gly-NH2
Sequence Shortening

{Glp}-HWSY-{d-Lys}-LRPG-NH2
선적

Room temperature in continental US; may vary elsewhere.

보관

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

용액&용해도

In Vitro:

DMSO : 100 mg/mL (79.78 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

0.7978 mL

3.9891 mL

7.9782 mL

5 mM

0.1596 mL

0.7978 mL

1.5956 mL

10 mM

0.0798 mL

0.3989 mL

0.7978 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
SDS (420 KB)
- English - EN (420 KB)
- Français - FR (420 KB)
- Deutsch - DE (420 KB)
- Norwegian - NO (420 KB)
- Español - ES (420 KB)
- Swedish - SV (420 KB)
- Italian - IT (420 KB)
- Korean - KR (420 KB)
- Portuguese - PT (420 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Pinski J, et al. Inhibition of growth of experimental prostate cancer in rats by LH-RH analogs linked to cytotoxic radicals. Prostate. 1993;23(2):165-78. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	0.7978 mL	3.9891 mL	7.9782 mL	19.9456 mL
	5 mM	0.1596 mL	0.7978 mL	1.5956 mL	3.9891 mL
	10 mM	0.0798 mL	0.3989 mL	0.7978 mL	1.9946 mL
	15 mM	0.0532 mL	0.2659 mL	0.5319 mL	1.3297 mL
	20 mM	0.0399 mL	0.1995 mL	0.3989 mL	0.9973 mL
	25 mM	0.0319 mL	0.1596 mL	0.3191 mL	0.7978 mL
	30 mM	0.0266 mL	0.1330 mL	0.2659 mL	0.6649 mL
	40 mM	0.0199 mL	0.0997 mL	0.1995 mL	0.4986 mL
	50 mM	0.0160 mL	0.0798 mL	0.1596 mL	0.3989 mL
	60 mM	0.0133 mL	0.0665 mL	0.1330 mL	0.3324 mL

Keywords

MOQ

Minimum order quantity

100 mg

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Other size

견적 받기

Amount: USD 0.00

Biological Activity
- 제품 설명
- In Vivo
Chemical Information
용액&용해도
- In Vitro
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
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[D-Lys6]-LH-RH

Endocrinology Compound Library

Peptide Library

Heterocyclic Compound Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Bioactive Compound Library Max

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Lactylation Compound Library

GPCR/G Protein Compound Library

Anti-Cancer Compound Library

Peptide Compound Library

Biological Activity

Chemical Information

용액&용해도

순도&문서

References

Help & FAQs

Complete Stock Solution Preparation Table

[D-Lys6]-LH-RH

Endocrinology Compound Library

Peptide Library

Heterocyclic Compound Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Bioactive Compound Library Max

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Lactylation Compound Library

GPCR/G Protein Compound Library

Anti-Cancer Compound Library

Peptide Compound Library

Biological Activity

Chemical Information

용액&용해도

순도&문서

References

Help & FAQs

Complete Stock Solution Preparation Table

[D-Lys6]-LH-RH Related Classifications

HY-P3668 Related Classifications