NK3R antagonist-1
NK3R antagonist-1 is an orally active neurokinin-3 receptor (NK3R) antagonist with an IC50 of 53.61 nM. NK3R antagonist-1 reduces plasma luteinizing hormone (LH) levels in ovariectomized rat models. NK3R antagonist-1 is applicable to research related to menopausal hot flushes.
For research use only. We do not sell to patients.
- Formula: C20H18FN5OS
- Molecular Weight:395.45
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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NK3R 53.61 nM (IC50) |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Sprague-Dawley (male, 8-12 weeks old, ovariectomized)[1]
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Dosage:120 mg/kg
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Administration:i.g.; single dose
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Result:Significantly reduced plasma luteinizing hormone (LH) levels, with inhibitory effect evident at 45 min post-dose, and statistically significant differences relative to vehicle control observed at both 45 and 90 min post-dose.
Chemical Information
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Molecular Weight 395.45
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Formula C20H18FN5OS
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SMILES
CC1=NSC(C2=NC(C#CC)=C([C@H]3C)N2CCN3C(C4=CC=C(F)C=C4)=O)=N1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
NK3R antagonist-1 Related Classifications
HY-181682 Related Classifications
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