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Results for "

melastatin

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Autophagy (3) Endogenous Metabolite (3) Environmental Pollutants (1) Eukaryotic Initiation Factor (eIF) (1) Ferroptosis (2) Isotope-Labeled Compounds (1) Potassium Channel (1) PPAR (3) Reactive Oxygen Species (ROS) (1) Reference Standards (3) TRP Channel (22)
By Research Areas:	Cancer (10) Inflammation/Immunology (6) Metabolic Disease (5) Neurological Disease (7)
Oligonucleotides:	Flavoring Agents (1)

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Natural
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Isotope-Labeled Compounds

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-75161

(-)-Menthol 4 Publications Verification	Environmental Pollutants Endogenous Metabolite TRP Channel	Cancer
(-)-Menthol is a key component of peppermint oil that binds and activates transient receptor potential melastatin 8 (TRPM8), a Ca ²⁺-permeable nonselective cation channel, to increase [Ca ²⁺]_i . Antitumor activity .

HY-14307

Necrocide 1 2 Publications Verification	TRP Channel Eukaryotic Initiation Factor (eIF) Reactive Oxygen Species (ROS)	Cancer
Necrocide 1, a necrosis by sodium overload (NECSO) inducer, is a selective transient receptor potential melastatin 4 (TRPM4) agonist with an EC₅₀ of 306.3 nM for human TRPM4. Necrocide 1 triggers TRPM4-dependent necrotic cell death through the induction of sodium influx. Necrocide 1 induces hallmarks of immunogenic cell death incurring calreticulin (CALR) exposure, ATP secretion and high mobility group box 1 (HMGB1) release. Necrocide 1 can be used for the study of breast and prostate cancer .

HY-14600

Rosiglitazone maleate Maximum Cited Publications 175 Publications Verification BRL 49653C	PPAR TRP Channel Autophagy Ferroptosis	Metabolic Disease Inflammation/Immunology Cancer
Rosiglitazone maleate (BRL 49653C) is a potent and selective activator of PPARγ, with EC₅₀s of 30 nM, 100 nM and 60 nM for PPARγ1, PPARγ2, and PPARγ, respectively, and a K_d of appr 40 nM for PPARγ; Rosiglitazone maleate is also an modulator of TRP channels, inhibits TRP melastatin 2 (TRPM2), TRPM3 and activates TRP canonical 5 (TRPC5).

HY-115506

PF-05105679	TRP Channel	Neurological Disease
PF-05105679, a chemical probe, is an orally active and selective TRPM8 antagonist with an IC₅₀ of 103 nM. PF-05105679 has the potential for cold-related pain .

HY-N8264

Moringin 1 Publications Verification	TRP Channel	Neurological Disease Inflammation/Immunology Cancer
Moringin is a potent and selective TRPA1 ion channel natural agonist with an EC₅₀ of 3.14 μM. Moringin does not activate or activates very weakly the vanilloids somatosensory channels TRPV1, TRPV2, TRPV3 and TRPV4, and the melastatin cooling receptor TRPM8. Moringin has hypoglycemic, antimicrobial, anti-inflammatory, anticancer and neuroprotection activities .

HY-110181

M8-B 1 Publications Verification	TRP Channel	Metabolic Disease
M8-B is a potent *transient receptor potential melastatin-8 (TRPM8)* antagonist. M8-B blocks cold-induced and TRPM8-agonist-induced activation TRPM8 channels. M8-B decreases deep body temperature (Tb) .

HY-128172

TRPM4-IN-2 5 Publications Verification NBA	TRP Channel	Cancer
TRPM4-IN-2 (NBA) is a potent *transient receptor potential melastatin* 4 (TRPM4) inhibitor with an IC₅₀** value of 0.16 μM. TRPM4-IN-2 can be used for researching prostate cancer and colorectal cancer .

HY-16162A

D-3263 hydrochloride 1 Publications Verification	TRP Channel	Cancer
D-3263 hydrochloride is an enteric-coated, orally bioavailable (transient receptor potential melastatin member 8) TRPM8 agonist.

HY-110199

TC-I 2014	TRP Channel	Neurological Disease
TC-I 2014 (compound 5) is a potent and orally active Benzimidazole-containing *transient receptor potential melastatin* 8 (TRPM8) antagonist, with IC₅₀** values of 0.8 nM, 3.0 nM and 4.4 nM for canine, human and rat channels respectively. TC-I 2014 exhibits antiallodynic properties in pain models .

HY-108461

TRPM8-IN-1	TRP Channel	Neurological Disease
TRPM8-IN-1 (example 14) is an inhibitor of transient receptor potential melastatin-8 (TRPM8) channels, IC₅₀<5 μM .

HY-104059

AMG2850 1 Publications Verification	TRP Channel	Inflammation/Immunology
AMG2850 is a potent, orally bioavailable and selective *transient receptor potential melastatin* 8 (TRPM8)** antagonist .

HY-75161R

(-)-Menthol (Standard)	Reference Standards TRP Channel Endogenous Metabolite	Cancer
(-)-Menthol (Standard) is the analytical standard of (-)-Menthol. This product is intended for research and analytical applications. (-)-Menthol is a key component of peppermint oil that binds and activates transient receptor potential melastatin 8 (TRPM8), a Ca2+-permeable nonselective cation channel, to increase [Ca2+]i . Antitumor activity .

HY-137952

NS8593	Potassium Channel TRP Channel	Neurological Disease
NS8593 is an SK channel (small conductance Ca ²⁺-activated K+ channels) inhibitor. NS8593 reversibly inhibited recombinant SK3-mediated currents (human SK3 and rat SK3). NS8593 inhibits all the SK1-3 subtypes Ca ²⁺-dependently (K_d = 0.42, 0.60, and 0.73 μM, respectively, at 0.5 μM Ca ²⁺). NS8593 does not affect the Ca ²⁺-activated K channels of intermediate and large conductance (hlk and hBK channels, respectively). NS8593 can also inhibit TRPM7 (melastatin-related TRP cation channel 7) (IC₅₀ = 1.6 mM). NS8593 can be used for the study of central nervous system (CNS) related diseases .

HY-137704

2′-Deoxy-ADPR	TRP Channel	Others
2′-Deoxy-ADPR is an agonist for transient receptor potential melastatin 2 channel (TRPM2 channel). 2′-Deoxy-ADPR may acts as the signaling molecule in Jurkat T-lymphocytes .

HY-117372

DFL23448	TRP Channel	Metabolic Disease
DFL23448 is a selective transient receptor potential melastatin-8 (TRPM8) antagonist. DFL23448 shows IC₅₀ values of 10 and 21 nM in hTRPM8 human embryonic kidney 293 cells activated by Cooling Agent 10 or cold. DFL23448 has limited activity (IC₅₀ >10 μM) at transient receptor potential vanilloids TRPV1, TRPA1, or TRPV4 or at various G protein-coupled receptors. DFL23448 can modify bladder function and reduce bladder overactivity in awake rats .

HY-16162

D-3263	TRP Channel	Cancer
D-3263 is an agonist of transient receptor potential melastatin member 8 (TRPM8) with potential antineoplastic activity.

HY-W711474

(-)-Menthol-d4	Isotope-Labeled Compounds TRP Channel Endogenous Metabolite	Cancer
(-)-Menthol-d₄ is the deuterium labeled (-)-Menthol (HY-75161). (-)-Menthol is a key component of peppermint oil that binds and activates transient receptor potential melastatin 8 (TRPM8), a Ca2+-permeable nonselective cation channel, to increase [Ca2+]i . Antitumor activity .

HY-173449

TRPM2-IN-1	TRP Channel	Neurological Disease
TRPM2-IN-1 (compound D10) is a potent TRPM2 inhibitor. TRPM2-IN-1 exhibits antistroke activity and significant neuroprotective effect. TRPM2-IN-1 can be used in the study of ischemic stroke .

HY-B0700

Rosiglitazone sodium BRL 49653 sodium	PPAR TRP Channel Autophagy	Metabolic Disease Inflammation/Immunology
Rosiglitazone sodium is a potent and selective activator of PPARγ, with EC₅₀s of 30 nM, 100 nM and 60 nM for PPARγ1, PPARγ2, and PPARγ, respectively, and a K_d of appr 40 nM for PPARγ; Rosiglitazone sodium is also an modulator of TRP channels, inhibits TRP melastatin 2 (TRPM2), TRPM3 and activates TRP canonical 5 (TRPC5).

HY-14600R

Rosiglitazone maleate (Standard) BRL 49653C (Standard)	Reference Standards PPAR TRP Channel Autophagy Ferroptosis	Metabolic Disease Inflammation/Immunology Cancer
Rosiglitazone (maleate) (Standard) is the analytical standard of Rosiglitazone (maleate). This product is intended for research and analytical applications. Rosiglitazone maleate (BRL 49653C) is a potent and selective activator of PPARγ, with EC₅₀s of 30 nM, 100 nM and 60 nM for PPARγ1, PPARγ2, and PPARγ, respectively, and a K_d of appr 40 nM for PPARγ; Rosiglitazone maleate is also an modulator of TRP channels, inhibits TRP melastatin 2 (TRPM2), TRPM3 and activates TRP canonical 5 (TRPC5).

HY-182466

Ponometrep BHV-2100	TRP Channel	Neurological Disease
Ponometrep (BHV-2100) is a *transient receptor potential melastatin* 3 (TRPM3) antagonist with IC₅₀** values of 1-10 nM. Ponometrep shows analgesic activity and can be used for the research of neurological diseases .

HY-104059R

AMG2850 (Standard)	Reference Standards TRP Channel	Inflammation/Immunology
AMG2850 (Standard) is the analytical standard of AMG2850 (HY-104059). This product is intended for research and analytical applications. AMG2850 is a potent, orally bioavailable and selective transient receptor potential melastatin 8 (TRPM8) antagonist .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-75161

(-)-Menthol 4 Publications Verification	Structural Classification Other Monoterpenes Classification of Application Fields Terpenoids Labiatae Erythrina poeppigiana Plants Endogenous metabolite Disease Research Fields Source Classification Cancer	Environmental Pollutants Endogenous Metabolite TRP Channel
(-)-Menthol is a key component of peppermint oil that binds and activates transient receptor potential melastatin 8 (TRPM8), a Ca ²⁺-permeable nonselective cation channel, to increase [Ca ²⁺]_i . Antitumor activity .

HY-N8264

Moringin 1 Publications Verification	Structural Classification Natural Products Neurological Disease Classification of Application Fields Moringa oleifera Lam. Moringaceae Plants Inflammation/Immunology Disease Research Fields Source Classification	TRP Channel
Moringin is a potent and selective TRPA1 ion channel natural agonist with an EC₅₀ of 3.14 μM. Moringin does not activate or activates very weakly the vanilloids somatosensory channels TRPV1, TRPV2, TRPV3 and TRPV4, and the melastatin cooling receptor TRPM8. Moringin has hypoglycemic, antimicrobial, anti-inflammatory, anticancer and neuroprotection activities .

HY-75161R

(-)-Menthol (Standard)	Structural Classification Other Monoterpenes Human Gut Microbiota Metabolites Microorganisms Terpenoids Labiatae Erythrina poeppigiana Plants Endogenous metabolite Source Classification	Reference Standards TRP Channel Endogenous Metabolite
(-)-Menthol (Standard) is the analytical standard of (-)-Menthol. This product is intended for research and analytical applications. (-)-Menthol is a key component of peppermint oil that binds and activates transient receptor potential melastatin 8 (TRPM8), a Ca2+-permeable nonselective cation channel, to increase [Ca2+]i . Antitumor activity .

Cat. No.	Product Name	Chemical Structure

HY-W711474

(-)-Menthol-d4
(-)-Menthol-d₄ is the deuterium labeled (-)-Menthol (HY-75161). (-)-Menthol is a key component of peppermint oil that binds and activates transient receptor potential melastatin 8 (TRPM8), a Ca2+-permeable nonselective cation channel, to increase [Ca2+]i . Antitumor activity .

Cat. No.	Product Name		Classification

HY-75161

(-)-Menthol 4 Publications Verification		Flavoring Agents
(-)-Menthol is a key component of peppermint oil that binds and activates transient receptor potential melastatin 8 (TRPM8), a Ca ²⁺-permeable nonselective cation channel, to increase [Ca ²⁺]_i . Antitumor activity .

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melastatin

Inhibitors & Agonists

NaturalProducts

Isotope-Labeled Compounds

Oligonucleotides

Natural
Products