2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. TRP Channel
  4. Ponometrep

Ponometrep (BHV-2100) is a transient receptor potential melastatin 3 (TRPM3) antagonist with IC50 values of 1-10 nM. Ponometrep shows analgesic activity and can be used for the research of neurological diseases.

For research use only. We do not sell to patients.

Ponometrep

Ponometrep Chemical Structure

CAS No. : 2776175-74-5

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in DMSO In-stock
Solid
5 mg In-stock
10 mg In-stock
25 mg In-stock
50 mg In-stock
100 mg In-stock
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Ponometrep Related Antibodies

Top Publications Citing Use of Products

View All TRP Channel Isoform Specific Products:

View All Isoforms
TRPA1 TRPC3 TRPC4 TRPC5 TRPC6 TRPC7 TRPM8 TRPM2 TRPM3 TRPM4 TRPM7 TRPML1 TRPML2 TRPML3 TRPV1 TRPV2 TRPV3 TRPV4 TRPV6

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Ponometrep (BHV-2100) is a transient receptor potential melastatin 3 (TRPM3) antagonist with IC50 values of 1-10 nM. Ponometrep shows analgesic activity and can be used for the research of neurological diseases[1].

IC50 & Target[1]

TRPM3

1-10 nM (IC50)

In Vitro

Ponometrep inhibits human, mouse, and rat TRPM3 with IC50 values between 1-10 nM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ponometrep Related Antibodies
In Vivo

Ponometrep inhibits PS-evoked pain responses in mice and rats with an ED50 of 1.3 mg/kg and 2.5 mg/kg, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

389.43

Formula

C18H19N3O5S
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

CC1=NC=C(S1)COC2=CC=C3OC(C)=C(C3=C2)C(N[C@H](C(N)=O)CO)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (128.39 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5679 mL 12.8393 mL 25.6786 mL
5 mM 0.5136 mL 2.5679 mL 5.1357 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.28%

SDS (252 KB)

COA (249 KB) HNMR (185 KB) LCMS (103 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5679 mL 12.8393 mL 25.6786 mL 64.1964 mL
5 mM 0.5136 mL 2.5679 mL 5.1357 mL 12.8393 mL
10 mM 0.2568 mL 1.2839 mL 2.5679 mL 6.4196 mL
15 mM 0.1712 mL 0.8560 mL 1.7119 mL 4.2798 mL
20 mM 0.1284 mL 0.6420 mL 1.2839 mL 3.2098 mL
25 mM 0.1027 mL 0.5136 mL 1.0271 mL 2.5679 mL
30 mM 0.0856 mL 0.4280 mL 0.8560 mL 2.1399 mL
40 mM 0.0642 mL 0.3210 mL 0.6420 mL 1.6049 mL
50 mM 0.0514 mL 0.2568 mL 0.5136 mL 1.2839 mL
60 mM 0.0428 mL 0.2140 mL 0.4280 mL 1.0699 mL
80 mM 0.0321 mL 0.1605 mL 0.3210 mL 0.8025 mL
100 mM 0.0257 mL 0.1284 mL 0.2568 mL 0.6420 mL
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Ponometrep Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ponometrep2776175-74-5BHV-2100BHV2100BHV 2100TRP ChannelTransient receptor potential channelsmouse modelTRPM3migraine painpregnenolone sulfateion channelsInhibitorinhibitorinhibit

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