2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. TRP Channel
  4. TC-I 2014

TC-I 2014 

Cat. No.: HY-110199 Purity: ≥99.0%
COA Handling Instructions

TC-I 2014 (compound 5) is a potent and orally active Benzimidazole-containing transient receptor potential melastatin 8 (TRPM8) antagonist, with IC50 values of 0.8 nM, 3.0 nM and 4.4 nM for canine, human and rat channels respectively. TC-I 2014 exhibits antiallodynic properties in pain models.

For research use only. We do not sell to patients.

TC-I 2014 Chemical Structure

TC-I 2014 Chemical Structure

CAS No. : 1221349-53-6

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Based on 1 publication(s) in Google Scholar

TC-I 2014 Related Antibodies

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Description

TC-I 2014 (compound 5) is a potent and orally active Benzimidazole-containing transient receptor potential melastatin 8 (TRPM8) antagonist, with IC50 values of 0.8 nM, 3.0 nM and 4.4 nM for canine, human and rat channels respectively. TC-I 2014 exhibits antiallodynic properties in pain models[1].

IC50 & Target

TRPM8[1].
In Vitro

TC-I 2014 (compound 5) potently inhibits cold-induced TRPM8 currents in HEK293 cells stably expressing canine or human TRPM8, with IC50 values of 0.413 and 1 nM, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

TC-I 2014 Related Antibodies
In Vivo

TC-I 2014 (10 mg/kg, Orally once) completely prevents icilin-induced WDS[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: TC-I 2014 (10 mg/kg, Orally once) completely prevents icilin-induced WDS[1].
Dosage: 3, 5.6, 10 mg/kg.
Administration: Orally once.
Result: Produced greater than 90% inhibition at 3, 5.6, and 10 mg/kg administered 2 h prior to icilin challenge.
Molecular Weight

467.41

Appearance

Solid

Formula

C23H19F6N3O
CAS No.
SMILES

FC(C1=CC=CC=C1C2=CC(C(F)(F)F)=C3C(N=C(C4=NOC5(CCCCC5)C4)N3)=C2)(F)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (534.86 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1394 mL 10.6972 mL 21.3945 mL
5 mM 0.4279 mL 2.1394 mL 4.2789 mL
10 mM 0.2139 mL 1.0697 mL 2.1394 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation

Purity: ≥99.0%

COA (251 KB) Elemental Analysis Report (109 KB)

Handling Instructions (2659 KB)
References
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TC-I 2014 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Keywords:

TC-I 20141221349-53-6TRP ChannelTransient receptor potential channelsInhibitorinhibitorinhibit

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