1. Membrane Transporter/Ion Channel
  2. TRP Channel
  3. TC-I 2014

TC-I 2014 

Cat. No.: HY-110199 Purity: >99.0%
Handling Instructions

TC-I 2014 (compound 5) is a potent Benzimidazole-containing transient receptor potential melastatin 8 (TRPM8) antagonist, with IC50 values of 0.8 nM, 3.0 nM and 4.4 nM for canine, human and rat channels respectively. TC-I 2014 exhibits antiallodynic properties in pain models.

For research use only. We do not sell to patients.

TC-I 2014 Chemical Structure

TC-I 2014 Chemical Structure

CAS No. : 1221349-53-6

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10 mM * 1 mL in DMSO USD 385 In-stock
Estimated Time of Arrival: December 31
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

TC-I 2014 (compound 5) is a potent Benzimidazole-containing transient receptor potential melastatin 8 (TRPM8) antagonist, with IC50 values of 0.8 nM, 3.0 nM and 4.4 nM for canine, human and rat channels respectively. TC-I 2014 exhibits antiallodynic properties in pain models[1].

IC50 & Target

TRPM8[1].

Molecular Weight

467.41

Formula

C₂₃H₁₉F₆N₃O

CAS No.

1221349-53-6

SMILES

FC(C1=CC=CC=C1C2=CC(C(F)(F)F)=C3C(N=C(C4=NOC5(CCCCC5)C4)N3)=C2)(F)F

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
References

Purity: >99.0%

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TC-I 2014
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