1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. TRP Channel
  3. D-3263

D-3263 

Cat. No.: HY-16162
Handling Instructions

D-3263 is an agonist of transient receptor potential melastatin member 8 (TRPM8) with potential antineoplastic activity.

For research use only. We do not sell to patients.

D-3263 Chemical Structure

D-3263 Chemical Structure

CAS No. : 947257-66-1

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Description

D-3263 is an agonist of transient receptor potential melastatin member 8 (TRPM8) with potential antineoplastic activity.

In Vitro

D-3263 induces calcium flux and cell death in in vitro cells expressing TRPM8[1].

In Vivo

D-3263 (50 or 100 mg/kg/d) alone or with Finasteride (10 mg/kg/d) results in reduction in prostate hyperplasia of rats with evidence of a dose response. The highest dose of the TRPM8 agonist D-3263, given in combination with Finasteride, results in lower prostate weights than the highest dose of D-3263 or Finasteride given alone, suggesting a potential additive effect[1].

Clinical Trial
Molecular Weight

373.49

Formula

C₂₁H₃₁N₃O₃

CAS No.

947257-66-1

SMILES

O=C1N(CCN)C2=CC(OC)=CC=C2N1C([[email protected]]3[[email protected]](C(C)C)CC[[email protected]@H](C)C3)=O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

D-3263D3263D 3263TRP ChannelTransient receptor potential channelsInhibitorinhibitorinhibit

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