1. Membrane Transporter/Ion Channel
  2. TRP Channel

D-3263 

Cat. No.: HY-16162
Handling Instructions

D-3263 is an agonist of transient receptor potential melastatin member 8 (TRPM8) with potential antineoplastic activity.

For research use only. We do not sell to patients.

D-3263 Chemical Structure

D-3263 Chemical Structure

CAS No. : 947257-66-1

Size Price Stock
1 mg USD 768 Get quote
5 mg USD 1536 Get quote
10 mg USD 2664 Get quote
20 mg USD 4668 Get quote

* Please select Quantity before adding items.

Other In-stock Forms of D-3263:

Customer Review

Other Forms of D-3263:

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

D-3263 is an agonist of transient receptor potential melastatin member 8 (TRPM8) with potential antineoplastic activity.

In Vitro

D-3263 induces calcium flux and cell death in in vitro cells expressing TRPM8[1].

In Vivo

D-3263 (50 or 100 mg/kg/d) alone or with Finasteride (10 mg/kg/d) results in reduction in prostate hyperplasia of rats with evidence of a dose response. The highest dose of the TRPM8 agonist D-3263, given in combination with Finasteride, results in lower prostate weights than the highest dose of D-3263 or Finasteride given alone, suggesting a potential additive effect[1].

Clinical Trial
Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6774 mL 13.3872 mL 26.7745 mL
5 mM 0.5355 mL 2.6774 mL 5.3549 mL
10 mM 0.2677 mL 1.3387 mL 2.6774 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

373.49

Formula

C₂₁H₃₁N₃O₃

CAS No.

947257-66-1

SMILES

O=C1N(CCN)C2=CC(OC)=CC=C2N1C([[email protected]]3[[email protected]](C(C)C)CC[[email protected]@H](C)C3)=O

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Inquiry Online

Your information is safe with us. * Required Fields.

Product name

 

Salutation

Applicant name *

 

Email address *

Phone number *

 

Organization name *

Country or Region *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
D-3263
Cat. No.:
HY-16162
Quantity:

D-3263

Cat. No.: HY-16162