DFL23448
DFL23448 is a selective transient receptor potential melastatin-8 (TRPM8) antagonist. DFL23448 shows IC50 values of 10 and 21 nM in hTRPM8 human embryonic kidney 293 cells activated by Cooling Agent 10 or cold. DFL23448 has limited activity (IC50 >10 μM) at transient receptor potential vanilloids TRPV1, TRPA1, or TRPV4 or at various G protein-coupled receptors. DFL23448 can modify bladder function and reduce bladder overactivity in awake rats.
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- CAS No.: 1445753-16-1
- Formule: C12H10FN5OS
- Masse moléculaire:291.30
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
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TRPM8 |
Chemical Information
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CAS No. 1445753-16-1
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Masse moléculaire 291.30
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Formule C12H10FN5OS
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SMILES
OC1=C(C2=NN(CC)N=N2)SC(C3=CC=CC(F)=C3)=N1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DFL23448 Related Classifications
HY-117372 Related Classifications
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