1445753-16-1
Chemical Structure
DFL23448
- CAS No.: 1445753-16-1
- Formula:C12H10FN5OS
- Molecular Weight:291.30
IUPAC Name: 5-(2-ethyl-2H-tetrazol-5-yl)-2-(3-fluorophenyl)thiazol-4-ol
InChIKey: HOVUYEIYKRUBIF-UHFFFAOYSA-N
SMILES: OC1=C(C2=NN(CC)N=N2)SC(C3=CC=CC(F)=C3)=N1
Biological Activity: DFL23448 is a selective transient receptor potential melastatin-8 (TRPM8) antagonist. DFL23448 shows IC50 values of 10 and 21 nM in hTRPM8 human embryonic kidney 293 cells activated by Cooling Agent 10 or cold. DFL23448 has limited activity (IC50 >10 μM) at transient receptor potential vanilloids TRPV1, TRPA1, or TRPV4 or at various G protein-coupled receptors. DFL23448 can modify bladder function and reduce bladder overactivity in awake rats[1].
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DFL23448 | DFL23448 is a selective transient receptor potential melastatin-8 (TRPM8) antagonist. DFL23448 shows IC50 values of 10 and 21 nM in hTRPM8 human embryonic kidney 293 cells activated by Cooling Agent 10 or cold. DFL23448 has limited activity (IC50 >10 μM) at transient receptor potential vanilloids TRPV1, TRPA1, or TRPV4 or at various G protein-coupled receptors. DFL23448 can modify bladder function and reduce bladder overactivity in awake rats. | |||||||||||||||||||||
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