Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
24 Results for "
mycobacterial infection
" in MedChemExpress (MCE) Product Catalog:
Products (24)
24 Results for "mycobacterial infection" in MCE Product Catalog:
2
2 Cited Publications
Cat. No.: HY-45854
CAS No.: 1645486-93-6
GWP-042 is a potent inhibitor of mycobacterial alanine dehydrogenase (Ald) Rv2780, with the IC50 of 0.21 μM. GWP-042 has antimicrobial activity against M. tuberculosis infection in vivo .
1
MAC13772 is a BioA inhibitor with an IC50 of 0.28 μM against E. coli and an IC50 of 0.269 μM against A. baumannii. MAC13772 inhibits bacterial growth by targeting the biotin biosynthesis pathway. MAC13772 can be used in studies related to bacterial infections .
Cat. No.: HY-W506116
CAS No.: 148-83-4
Synonyms: Ostruthine
Target:
Research Areas:
Ostruthin is a natural coumarin compound with bacterial and antimycobacterial activities . Ostruthin inhibits the growth of mycobacteria and Staphylococcus aureus. Ostruthin suppresses vascular smooth muscle cell proliferation as well as de novo cellular DNA synthesis. Ostruthin is applicable to research related to mycobacterial infections and cardiovascular and cerebrovascular diseases .
Cat. No.: HY-N15643
CAS No.: 23040-84-8
Synonyms: α-MA (C80)
Category:
Target:
Cat. No.: HY-162836
CAS No.: 13929-35-6
Synonyms: 4-O-(Carboxymethyl)-Rifamycin
Target:
Research Areas:
Rifamycin B (4-O-(Carboxymethyl)-Rifamycin) is a member of ansamycin antibiotics family with an anti-mycobacterial activity against tuberculosis, leprosy and AIDS-related mycobacterial infections. Rifamycin B is a metabolic product of Nocardia inediterranei, which can yield Rifamycin O and Rifamycin S (HY-125365) by microbial transformation .
Cat. No.: HY-N15645
CAS No.: 2260795-20-6
Category:
Target:
Category:
Target:
Cat. No.: HY-146158
CAS No.: 1859978-72-5
Synonyms: WX-081; Sudapyridine
Target:
Research Areas:
Fudapirine (WX-081; Sudapyridine) is an orally active bactericidal agent that targets mycobacterial ATP synthase. Fudapirine induces mycobacterial death by inhibiting ATP synthesis, disrupting proton motive force and depleting bacterial energy. Fudapirine can be used in the research of tuberculosis and *Mycobacterium tuberculosis* infection .
Cat. No.: HY-W250306
CAS No.: 4197-24-4
Cat. No.: HY-15993
CAS No.: 252260-02-9
Synonyms: AZD2563; AZD5847
Target:
Research Areas:
Posizolid (AZD2563), an oxazolidinone antibiotic, is developed by AstraZeneca for the study of bacterial infections. Posizolid shows very good anti-mycobacterial activity .
Cat. No.: HY-N15644
CAS No.: 23599-54-4
Category:
Target:
Cat. No.: HY-47597
CAS No.: 612829-80-8
Protein kinase G inhibitor-2 (Compound 266) is a mycobacterial protein kinase G inhibitor, with an IC50 of 3 μM. Protein kinase G inhibitor-2 can be used for mycobacterial infection research .
Cat. No.: HY-48958
CAS No.: 354544-70-0
Protein kinase G inhibitor-1 (Compound 270) is a mycobacterial protein kinase G inhibitor, with an IC50 of 0.9 μM. Protein kinase G inhibitor-1 can be used for mycobacterial infection research .
Cat. No.: HY-169587
CAS No.: 331964-66-0
Target:
Research Areas:
Protein kinase G inhibitor-3 (Compound 177) is an inhibitor of mycobacterial serine/threonine protein kinases. Protein kinase G inhibitor-3 can be used in the research of diseases related to mycobacterial infections .
Ethionamide hydrochloride (2-Ethylthioisonicotinamide hydrochloride) is an antituberculosis drug with mycobacterial activity. Ethionamide hydrochloride interferes with the bacterial cell wall synthesis process by inhibiting the synthesis of fatty acids in the bacterial cell wall. Ethionamide hydrochloride may have bacteriostatic or bactericidal effects, depending on the concentration of the drug at the site of infection and the susceptibility of the associated microorganisms. Ethionamide hydrochloride combines with NAD+ to form an adduct, thereby exerting its antibacterial effect .
Cat. No.: HY-113652
CAS No.: 1027102-49-3
UGM-IN-2 is a UGM inhibitor with a Kd of 20 μM. It binds to the UGM isoforms of K. pneumoniae (Klebsiella pneumoniae) and M. tuberculosis (Mycobacterium tuberculosis) and inhibits mycobacterial growth. UGM-IN-2 can be used in studies related to mycobacterial infections and tuberculosis .
Cat. No.: HY-184407
CAS No.: 1803030-41-2
Target:
Research Areas:
D-AAP1 is an RNA polymerase inhibitor. D-AAP1 exhibits anti-mycobacterial activity. D-AAP1 can be used for the research of mycobacterial infections .
Cat. No.: HY-186290
(-)-DMNP is an inhibitor targeting RelZ and Rel_Msm, with activity against mycobacteria. (-)-DMNP binds to structurally similar sites of RelZ and Rel_Msm, thereby inhibiting (p) ppGpp synthesis activity. (-)-DMNP inhibits the formation of persistent mycobacterial cells and eradicates their biofilms. (-)-DMNP can be used in the research of bacterial infections and tuberculosis .
- 1
- 2
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
