Ostruthin
Based on 1 Customer Validation
Ostruthin is a natural coumarin compound with bacterial and antimycobacterial activities. Ostruthin inhibits the growth of mycobacteria and Staphylococcus aureus. Ostruthin suppresses vascular smooth muscle cell proliferation as well as de novo cellular DNA synthesis. Ostruthin is applicable to research related to mycobacterial infections and cardiovascular and cerebrovascular diseases.
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- Pureza: 98.84%
- No. CAS: 148-83-4
- Fòrmula: C19H22O3
- Peso molecular:298.38
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Almacenamiento:
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Actividad biológica
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| VSMC | IC50 |
11 μM
Compound: 7
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Antiproliferative activity against serum-stimulated primary rat aortic VSMC after 30 mins by resazurin conversion assay
Antiproliferative activity against serum-stimulated primary rat aortic VSMC after 30 mins by resazurin conversion assay
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[PMID: 21627108] |
| VSMC | IC50 |
17 μM
Compound: 7
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Antiproliferative activity in primary rat aortic VSMC assessed as inhibition of serum-induced DNA synthesis pretreated 30 mins prior serum addition measured after 48 hrs by BrdU incorporation assay
Antiproliferative activity in primary rat aortic VSMC assessed as inhibition of serum-induced DNA synthesis pretreated 30 mins prior serum addition measured after 48 hrs by BrdU incorporation assay
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[PMID: 21627108] |
Ostruthin (72-120 h) potently inhibits the proliferation of various rapidly growing mycobacterial strains in vitro. Its minimum inhibitory concentration (MIC) against Mycobacterium abscesus, M. aurum, M. fortuitum, M. phlei and M. smegmatis ranges from 3.4 to 107.4 μM[1].
Ostruthine (1×10-4-1×10-3 M) potently inhibits the growth and cellular oxygen consumption of Staphylococcus aureus strain BS 270[2].
Ostruthin (Compound 7) (30 μM; 48 h) potently inhibits 10% serum-induced proliferation of rat aortic vascular smooth muscle cells, with an IC50 of 11 μM[3].
Ostruthin (1-30 μM; 20 h) concentration-dependently inhibits de novo DNA synthesis induced by 10% serum in rat aortic vascular smooth muscle cells, with an IC50 of 17 μM[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:rat aortic vascular smooth muscle cells (VSMC)
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Concentration:30 μM
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Incubation Time:48 h (with 30 min pretreatment)
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Result:Inhibited serum-induced VSMC proliferation with an IC50 of 11 μM.
Chemical Information
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No. CAS 148-83-4
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Appearance Solid
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Peso molecular 298.38
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Fòrmula C19H22O3
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Color White to off-white
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SMILES
C/C(C)=C\CC/C(C)=C/CC1=C(O)C=C2C(C=CC(O2)=O)=C1
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Synonyms
Ostruthine
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Pureza y Documentación
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Ficha de datos (268 KB)
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SDS (458 KB)
- English - EN (458 KB)
- Français - FR (458 KB)
- Deutsch - DE (458 KB)
- Norwegian - NO (458 KB)
- Español - ES (458 KB)
- Swedish - SV (458 KB)
- Italian - IT (458 KB)
- Korean - KR (458 KB)
- Portuguese - PT (458 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Schinkovitz A, et al. Ostruthin: an antimycobacterial coumarin from the roots of Peucedanum ostruthium. Planta Med. 2003;69(4):369-371. [Content Brief]
[3]. Joa H, et al. Identification of ostruthin from Peucedanum ostruthium rhizomes as an inhibitor of vascular smooth muscle cell proliferation. J Nat Prod. 2011;74(6):1513-1516. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Ostruthin Related Classifications
HY-W506116 Related Classifications
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