Ostruthin (Synonyms: Ostruthine)

Cat. No.: HY-W506116 Purity: 98.84%: Data Sheet
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Ostruthin is a natural coumarin compound with bacterial and antimycobacterial activities. Ostruthin inhibits the growth of mycobacteria and Staphylococcus aureus. Ostruthin suppresses vascular smooth muscle cell proliferation as well as de novo cellular DNA synthesis. Ostruthin is applicable to research related to mycobacterial infections and cardiovascular and cerebrovascular diseases.

For research use only. We do not sell to patients.

Ostruthin Chemical Structure

CAS No. : 148-83-4

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Description

Cellular Effect

Cell Line	Type	Value	Description	References
VSMC	IC₅₀	11 μM Compound: 7	Antiproliferative activity against serum-stimulated primary rat aortic VSMC after 30 mins by resazurin conversion assay Antiproliferative activity against serum-stimulated primary rat aortic VSMC after 30 mins by resazurin conversion assay	[PMID: 21627108]
VSMC	IC₅₀	17 μM Compound: 7	Antiproliferative activity in primary rat aortic VSMC assessed as inhibition of serum-induced DNA synthesis pretreated 30 mins prior serum addition measured after 48 hrs by BrdU incorporation assay Antiproliferative activity in primary rat aortic VSMC assessed as inhibition of serum-induced DNA synthesis pretreated 30 mins prior serum addition measured after 48 hrs by BrdU incorporation assay	[PMID: 21627108]

In Vitro

Ostruthin (72-120 h) potently inhibits the proliferation of various rapidly growing mycobacterial strains in vitro. Its minimum inhibitory concentration (MIC) against Mycobacterium abscesus, M. aurum, M. fortuitum, M. phlei and M. smegmatis ranges from 3.4 to 107.4 μM^[1].
Ostruthine (1×10^-4-1×10^-3 M) potently inhibits the growth and cellular oxygen consumption of Staphylococcus aureus strain BS 270^[2].
Ostruthin (Compound 7) (30 μM; 48 h) potently inhibits 10% serum-induced proliferation of rat aortic vascular smooth muscle cells, with an IC₅₀ of 11 μM^[3].
Ostruthin (1-30 μM; 20 h) concentration-dependently inhibits de novo DNA synthesis induced by 10% serum in rat aortic vascular smooth muscle cells, with an IC₅₀ of 17 μM^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[3]

Cell Line:	rat aortic vascular smooth muscle cells (VSMC)
Concentration:	30 μM
Incubation Time:	48 h (with 30 min pretreatment)
Result:	Inhibited serum-induced VSMC proliferation with an IC₅₀ of 11 μM.

Molecular Weight

298.38

Formula

C₁₉H₂₂O₃

CAS No.

148-83-4

Appearance

Solid

Color

White to off-white

SMILES

C/C(C)=C\CC/C(C)=C/CC1=C(O)C=C2C(C=CC(O2)=O)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Purity & Documentation

Purity: 98.84%

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Data Sheet (268 KB) SDS (458 KB)

COA (243 KB)

Handling Instructions (2659 KB)

References

[1]. Schinkovitz A, et al. Ostruthin: an antimycobacterial coumarin from the roots of Peucedanum ostruthium. Planta Med. 2003;69(4):369-371. [Content Brief]

[2]. V. DADÁK, et al. Neutralization of the Antibacterial Effect of Natural Coumarin Ostruthine by Vitamins K. Nature volume 205, pages709–710 (1965).

[3]. Joa H, et al. Identification of ostruthin from Peucedanum ostruthium rhizomes as an inhibitor of vascular smooth muscle cell proliferation. J Nat Prod. 2011;74(6):1513-1516. [Content Brief]

Ostruthin Related Classifications

Infection Cardiovascular Disease

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ostruthin148-83-4OstruthineBacterialDNA/RNA SynthesisAntibacterial agentmycobacteriaStaphylococcus aureusvascular smooth muscle cellmycobacterial infections and cardiovascularcerebrovascular diseases
Inhibitorinhibitorinhibit

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