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Posizolid (Synonyms: AZD2563; AZD5847)

Cat. No.: HY-15993
Handling Instructions

Posizolid (AZD2563), an oxazolidinone antibiotic, is developed by AstraZeneca for the study of bacterial infections. Posizolid shows very good anti-mycobacterial activity.

For research use only. We do not sell to patients.

Posizolid Chemical Structure

Posizolid Chemical Structure

CAS No. : 252260-02-9

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Description

Posizolid (AZD2563), an oxazolidinone antibiotic, is developed by AstraZeneca for the study of bacterial infections. Posizolid shows very good anti-mycobacterial activity[1].

IC50 & Target

Posizolid shows very good anti-mycobacterial activity[1].

In Vitro

Posizolid is determined the activity of against 250 highly resistant pneumococci and 267 drug-susceptible isolates. Posizolid MICs for 50 and 90% of the strains tested are 1 and 2 μg/ml and 0.5 and 1 μg/ml, respectively, for the two isolate groups[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

AZD5847 DSP (AZD2563 is prodrug) could not be detected in plasma 5 min after oral administration, suggesting rapid conversion of the prodrug to the parent molecule.
In PK analysis, AZD5847(5 mg/kg) shows a low clearance (4.7 ml/min/kg) and volume of distribution (0.5 liter/kg) in mice, the half-life is 1.3 h[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male BALB/c mice, aged 6 to 8 weeks, 30 to 40 g[3].
Dosage: 3, 10, 30, 100, 300, 600, and 900 mg/kg
Administration: oral; collect blood samples at 5 min, 10 min, 15 min, 30 min, 1 h, 2 h, 4 h, 6 h, and 24 h
Result: AZD5847 DSP can’t be detected in plasma 5 min.
Animal Model: Male BALB/c mice, aged 6 to 8 weeks, 30 to 40 g[3].
Dosage: 250 mg/kg
Administration: oral; collect blood and BAL fluid samples at 5 min, 15 min, 30 min, 1 h, 2 h, 4 h, 8 h, 16 h, 24 h, and 48 h
Result: AZD5847(5 mg/kg) shows a low clearance (4.7 ml/min/kg) and volume of distribution (0.5 liter/kg) in mice, the half-life is 1.3 h.
Molecular Weight

465.40

Formula

C₂₁H₂₁F₂N₃O₇

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Posizolid
Cat. No.:
HY-15993
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