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p53+inhibitor

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-15484
    Pifithrin-α hydrobromide
    Maximum Cited Publications
    97 Publications Verification

    Pifithrin hydrobromide; PFTα hydrobromide

    		 MDM-2/p53 Aryl Hydrocarbon Receptor Ferroptosis Apoptosis Cancer
    Pifithrin-α hydrobromide is a p53 inhibitor which blocks its transcriptional activity and prevents cells from apoptosis. Pifithrin-α hydrobromide is also an aryl hydrocarbon receptor (AhR) agonist.
    Pifithrin-α hydrobromide
  • HY-10959
    RG7112
    20+ Cited Publications

    RO5045337

    		 MDM-2/p53 E1/E2/E3 Enzyme Neurological Disease Cancer
    RG7112 is a potent, selective, orally active and blood-brain barrier crossed MDM2-p53 inhibitor, with an IC50 of 18 nM and a KD of 11 nM for binding to MDM2 .
    RG7112
  • HY-16702A
    Pifithrin-β hydrobromide
    20+ Cited Publications

    PFT β hydrobromide; Cyclic Pifithrin-α hydrobromide

    		 MDM-2/p53 Ferroptosis Cancer
    Pifithrin-β hydrobromide (PFT β hydrobromide) is a potent p53 inhibitor with an IC50 of 23 μM.
    Pifithrin-β hydrobromide
  • HY-123076
    Pifithrin-α, p-Nitro, Cyclic
    4 Publications Verification

    PFN-α

    		 MDM-2/p53 Neurological Disease
    Pifithrin-α, p-Nitro, Cyclic (PFN-α) is cell-permeable and active-form p53 inhibitor. Pifithrin-α, p-Nitro, Cyclic is one order magnitude more active than Pifithrin-α in protecting cortical neurons exposed to Etoposide (ED50=30 nM). Pifithrin-α, p-Nitro, Cyclic behaves as a p53 posttranscriptional activity inhibitor. Pifithrin-α, p-Nitro, Cyclic do not prevent p53 phosphorylation on the S15 residue .
    Pifithrin-α, p-Nitro, Cyclic
  • HY-169240
    MX69-102

    		MDM-2/p53 Cancer
    MX69-102 (compound MX69-102) is an MDM-2/p53 inhibitor, inducing MDM2 degradation, resulting in p53 activation and cancer cell apoptosis. MX69-102 shows effective inhibition on xenografted human MDM2-overexpressing ALL in SCID mice. .
    MX69-102
  • HY-16702
    Pifithrin-β

    PFT β; Cyclic Pifithrin-α

    		 MDM-2/p53 Cancer
    Pifithrin-β (PFT β) is a potent p53 inhibitor with an IC50 of 23 μM.
    Pifithrin-β
  • HY-162352
    SDU-071

    		Epigenetic Reader Domain Apoptosis Cancer
    SDU-071 is a potent and orally active inhibitor of BRD4-p53 inhibitor. SDU-071 inhibits MDA-MB-231 cells proliferation with an IC50 of 10.5 μM. SDU-071 induces cell cycle arrest and apoptosis .
    SDU-071
  • HY-100765
    BI-0252

    		MDM-2/p53 E1/E2/E3 Enzyme Cancer
    BI-0252 is an orally active, selective MDM2-p53 inhibitor with an IC50 of 4 nM. BI-0252 can induce tumor regressions in all animals of a mouse SJSA-1 xenograft, with concomitant induction of the tumor protein p53 (TP53) target genes and markers of apoptosis .
    BI-0252
  • HY-130437
    p-nitro-Pifithrin-α

    		MDM-2/p53 TGF-β Receptor Caspase Infection Metabolic Disease
    p-nitro-Pifithrin-α, a cell-permeable analog of pifithrin-α, is a potent p53 inhibitor. p-nitro-Pifithrin-α suppresses p53-mediated TGF-β1 expression in HK-2 cells. p-nitro-Pifithrin-α inhibits the activation of caspase-3 by Zika virus (ZIKV) strains. p-nitro-Pifithrin-α attenuates steatosis and liver injury in mice fed a high-fat diet [4]. non-alcoholic fatty liver disease .
    p-nitro-Pifithrin-α
  • HY-14967
    NSC 66811
    1 Publications Verification

    		 MDM-2/p53 Cancer
    NSC 66811 is a MDM2-p53 inhibitor, with a Ki of 120 nM for binding to MDM2 .
    NSC 66811
  • HY-18658A
    Siremadlin (R Enantiomer)

    NVP-HDM201 (R Enantiomer); HDM201 (R Enantiomer)

    		 MDM-2/p53 Others
    Siremadlin R Enantiomer (NVP-HDM201 R Enantiomer) is the R enantiomer of Siremadlin. Siremadlin is a potent and highly specific MDM-2/p53 inhibitor.
    Siremadlin (R Enantiomer)
  • HY-18052
    AM-8553

    		MDM-2/p53 Cancer
    AM-8553 is a MDM2/p53 inhibitor (KD: 0.4 nM for MDM2). AM-8553 has anti-tumor activity
    AM-8553
  • HY-15484R
    Pifithrin-α hydrobromide (Standard)

    Pifithrin hydrobromide (Standard); PFTα hydrobromide (Standard)

    		 MDM-2/p53 Aryl Hydrocarbon Receptor Ferroptosis Apoptosis Reference Standards Cancer
    Pifithrin-α (hydrobromide) (Standard) is the analytical standard of Pifithrin-α (hydrobromide). This product is intended for research and analytical applications. Pifithrin-α hydrobromide is a p53 inhibitor which blocks its transcriptional activity and prevents cells from apoptosis. Pifithrin-α hydrobromide is also an aryl hydrocarbon receptor (AhR) agonist.
    Pifithrin-α hydrobromide (Standard)
  • HY-151169
    MDM2/4-p53-IN-1

    		MDM-2/p53 Cancer
    MDM2/4-p53-IN-1 is a potent MDM2-p53 and MDM4-p53 inhibitor with IC50 values of 35.9, 57.4 nM, respectively. MDM2/4-p53-IN-1 shows antiproliferative activity .
    MDM2/4-p53-IN-1
  • HY-151172
    MDM2-p53-IN-15

    		MDM-2/p53 Apoptosis Cancer
    MDM2-p53-IN-15 is a MDM2-p53 inhibitor with an IC50 value of 26.1 nM. MDM2-p53-IN-15 inhibits the proliferation of various cancer cells and induces cell apoptosis. MDM2-p53-IN-15 can be used for the research of cancer .
    MDM2-p53-IN-15
  • HY-18329
    TDP-665759

    		MDM-2/p53 STAT Apoptosis Cancer
    TDP-665759 is an inhibitor for HDm2:p53 complex, and thus activates p53, inhibits STAT3 signaling pathway (EC50 of 5.90 μM) and the cell viability of p53 expressing A549R (IC50 of 7.02 μM). TDP-665759 induces apoptosis in HepG2. TDP-665759 exhibits antitumor efficacy in mouse models .
    TDP-665759
  • HY-131667
    Hdm2 E3 ligase inhibitor 1

    		MDM-2/p53 E1/E2/E3 Enzyme Cancer
    Hdm2 E3 ligase inhibitor 1 (Compound 1) is a reversible inhibitor for Hdm2 (an E3 ubiquitin ligase)-mediated ubiquitination of the p53 protein with an IC50 of 12.7 μM. Hdm2 E3 ligase inhibitor 1 binds Hdm2, blocks Hdm2-catalyzed ubiquitin transfer from preligated Ub-Ubc4 to p53, inhibits p53 ubiquitination, stabilizes p53 protein in tumor cell and exhibits antitumor efficacy .
    Hdm2 E3 ligase inhibitor 1

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