TDP-665759
TDP-665759 is an inhibitor for HDm2:p53 complex, and thus activates p53, inhibits STAT3 signaling pathway (EC50 of 5.90 μM) and the cell viability of p53 expressing A549R (IC50 of 7.02 μM). TDP-665759 induces apoptosis in HepG2. TDP-665759 exhibits antitumor efficacy in mouse models.
For research use only. We do not sell to patients.
- CAS No.: 787632-66-0
- Formula: C31H34Cl2IN5O2
- Molecular Weight:706.44
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| MCF7 | IC50 |
0.8 μM
Compound: 12k
|
Antiproliferative activity against wild type p53 MCF7 cell line
Antiproliferative activity against wild type p53 MCF7 cell line
|
[PMID: 16630722] |
| MDA-MB-231 | IC50 |
8 μM
Compound: 12k
|
Antiproliferative activity against mutant p53 MDA-MB-231 cell line
Antiproliferative activity against mutant p53 MDA-MB-231 cell line
|
[PMID: 16630722] |
Chemical Information
-
CAS No. 787632-66-0
-
Molecular Weight 706.44
-
Formula C31H34Cl2IN5O2
-
SMILES
O=C([C@H](C1=CC=C(Cl)C=C1)N2[C@@H](C3=CC=C(Cl)C=C3N)C)N(CCCN4CCN(C)CC4)C5=CC=C(I)C=C5C2=O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
TDP-665759 Related Classifications
HY-18329 Related Classifications
Powered by Bioz