MDM2-p53-IN-15
MDM2-p53-IN-15 is a MDM2-p53 inhibitor with an IC50 value of 26.1 nM. MDM2-p53-IN-15 inhibits the proliferation of various cancer cells and induces cell apoptosis. MDM2-p53-IN-15 can be used for the research of cancer.
For research use only. We do not sell to patients.
- Formula: C38H26Cl2N6O3
- Molecular Weight:685.56
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IC50: 26.1 nM (MDM2-p53)[1]
MDM2-p53-IN-15 (1–100 μM; 48 h) inhibits HCT116 cells proliferation[1]. MDM2-p53-IN-15 (10-20 μM; 72-96 h) affects SJSA-1, LNCaP and MCF-7 proliferation[1]. MDM2-p53-IN-15 (10-15 μM; 96 h) affects cell death and apoptosis in SJSA1 cells[1]. MDM2-p53-IN-15 (0-1 μM; 1 h 30 min) dissociates MDM2-p53 complexes[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HCT116 cells
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Concentration:1-100 μM
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Incubation Time:48 hours
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Result:Showed antiproliferative activity to HCT116 cells with an IC50 value of 18.8 μM.
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Cell Line:SJSA-1, LNCaP and MCF-7 cell lines
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Concentration:10-20 μM
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Incubation Time:72 and 96 hours
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Result:Inhibited SJSA-1, LNCaP and MCF-7 cells proliferation with IC50 values of 10.7, 11.4 and 9.7 μM, respectively.
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Cell Line:SJSA-1 cells
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Concentration:10-15 μM
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Incubation Time:96 hours
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Result:Approximately 1.3-fold increased LDH releases at a concentration of 15 μM approximately 1.3-fold increased and induced SJSA-1 cells death with loss of volume. Induced accumulation of cells in G0/G1 phase while decreased the percentage of cells in both S and G2/M phases, thus affects cell cycle.
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Cell Line:U87MG and SHSY-5Y cells
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Concentration:0-1 μM
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Incubation Time:1 h 30 min
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Result:Selectively inhibited MDM2-p53 PPIs with an IC50 value of 26.1 nM, while inhibited MDM4-p53 PPIs with a lower potency with an IC50 value of 219 nM.
Chemical Information
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Molecular Weight 685.56
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Formula C38H26Cl2N6O3
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SMILES
O=C(NC1=CC=CC(N2N=C(C=C2)C3=CC=CC=C3)=C1)C([C@@H]4C5=CC=CC(O)=C5)=NN([C@]46C(NC7=C6C=CC(Cl)=C7)=O)C8=CC=C(C=C8)Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MDM2-p53-IN-15 Related Classifications
HY-151172 Related Classifications
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