MDM2/4-p53-IN-1
MDM2/4-p53-IN-1 is a potent MDM2-p53 and MDM4-p53 inhibitor with IC50 values of 35.9, 57.4 nM, respectively. MDM2/4-p53-IN-1 shows antiproliferative activity.
For research use only. We do not sell to patients.
- CAS No.: 3037300-57-2
- Formula: C32H22Cl2N6O3
- Molecular Weight:609.46
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IC50: 35.9 nM (MDM2-p53); 57.4 nM (MDM4-p53)[1]
MDM2/4-p53-IN-1 (compound 3f) (0-100 μM; 48-96 h) shows antiproliferative activity with IC50 values of 20.9, 14.7, 11.5, 12.4 μM for HCT116, SJSA-1, LNCaP, MCF-7 cells, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HCT116, SJSA-1, LNCaP, MCF-7 cells
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Concentration:0-100 µM
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Incubation Time:48 h (HCT116), 72 h (MCF7), 96 h (SJSA-1, LNCaP)
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Result:Showed antiproliferative activity with IC50 values of 20.9, 14.7, 11.5, 12.4 µM for HCT116, SJSA-1, LNCaP, MCF-7 cells, respectively.
Chemical Information
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CAS No. 3037300-57-2
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Molecular Weight 609.46
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Formula C32H22Cl2N6O3
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SMILES
O=C1NC2=CC(Cl)=CC=C2[C@@]13N(N=C(C(NC4=CC(N5N=CC=C5)=CC=C4)=O)[C@@H]3C6=CC(O)=CC=C6)C7=CC=C(C=C7)Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MDM2/4-p53-IN-1 Related Classifications
HY-151169 Related Classifications
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