3037300-57-2
3037300-57-2
Chemical Structure
MDM2/4-p53-IN-1
- CAS No.: 3037300-57-2
- Formula:C32H22Cl2N6O3
- Molecular Weight:609.46
IUPAC Name: (3R,4'R)-N-(3-(1H-pyrazol-1-yl)phenyl)-6-chloro-2'-(4-chlorophenyl)-4'-(3-hydroxyphenyl)-2-oxo-2',4'-dihydrospiro[indoline-3,3'-pyrazole]-5'-carboxamide
InChIKey: KZVNWGAQQJSTDL-IUDBTDONSA-N
SMILES: O=C1NC2=CC(Cl)=CC=C2[C@@]13N(N=C(C(NC4=CC(N5N=CC=C5)=CC=C4)=O)[C@@H]3C6=CC(O)=CC=C6)C7=CC=C(C=C7)Cl
Biological Activity: MDM2/4-p53-IN-1 is a potent MDM2-p53 and MDM4-p53 inhibitor with IC50 values of 35.9, 57.4 nM, respectively. MDM2/4-p53-IN-1 shows antiproliferative activity[1].
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MDM2/4-p53-IN-1 | MDM2/4-p53-IN-1 is a potent MDM2-p53 and MDM4-p53 inhibitor with IC50 values of 35.9, 57.4 nM, respectively. MDM2/4-p53-IN-1 shows antiproliferative activity. | |||||||||||||||||||||
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