1. Apoptosis
  2. MDM-2/p53
  3. NSC 66811

NSC 66811 

Cat. No.: HY-14967
Handling Instructions

NSC 66811 is a MDM2-p53 inhibitor, with a Ki of 120 nM for binding to MDM2.

For research use only. We do not sell to patients.

NSC 66811 Chemical Structure

NSC 66811 Chemical Structure

CAS No. : 6964-62-1

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Description

NSC 66811 is a MDM2-p53 inhibitor, with a Ki of 120 nM for binding to MDM2[1].

In Vitro

NSC 66811 (0, 5, 10, 20 μM) dose-dependently induces the accumulation of p53, MDM2, and p21cip1/waf due to the functional activation of p53[1].

Western Blot Analysis[1]

Cell Line: HCT-116 (p53+/+ and p53-/-) cells[1].
Concentration: 0, 5, 10, 20 μM.
Incubation Time: 48 h.
Result: Dose-dependently induced the accumulation of p53, MDM2, and p21cip1/waf proteins in the HCT-116 human colon cancer cell line with wild-type p53.
Had no effect on the levels for p53, MDM2, and p21cip1/waf protein in the isogenic HCT-116 p53-/- cell line.
Molecular Weight

340.42

Formula

C₂₃H₂₀N₂O

CAS No.

6964-62-1

SMILES

OC1=C2N=C(C)C=CC2=CC=C1C(C3=CC=CC=C3)NC4=CC=CC=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

NSC 66811NSC66811NSC-66811MDM-2/p53HCT-116MDM2p53Inhibitorinhibitorinhibit

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NSC 66811
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