2. Apoptosis
  3. MDM-2/p53
  4. MX69-102

MX69-102 (compound MX69-102) is an MDM-2/p53 inhibitor, inducing MDM2 degradation, resulting in p53 activation and cancer cell apoptosis. MX69-102 shows effective inhibition on xenografted human MDM2-overexpressing ALL in SCID mice..

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MX69-102

MX69-102 Chemical Structure

CAS No. : 2925583-17-9

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in DMSO In-stock
Solid
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10 mg In-stock
25 mg In-stock
50 mg In-stock
100 mg In-stock
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Based on 1 publication(s) in Google Scholar

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Description

MX69-102 (compound MX69-102) is an MDM-2/p53 inhibitor, inducing MDM2 degradation, resulting in p53 activation and cancer cell apoptosis. MX69-102 shows effective inhibition on xenografted human MDM2-overexpressing ALL in SCID mice.[1].

Molecular Weight

518.62

Formula

C29H30N2O5S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=S(C1=CC2=C(NC(C3=CC=C(C(C(C)C)=O)C=C3)C4C2OCC4)C=C1)(NC5=CC=CC(C(C)=O)=C5)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (192.82 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9282 mL 9.6410 mL 19.2819 mL
5 mM 0.3856 mL 1.9282 mL 3.8564 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9282 mL 9.6410 mL 19.2819 mL 48.2049 mL
5 mM 0.3856 mL 1.9282 mL 3.8564 mL 9.6410 mL
10 mM 0.1928 mL 0.9641 mL 1.9282 mL 4.8205 mL
15 mM 0.1285 mL 0.6427 mL 1.2855 mL 3.2137 mL
20 mM 0.0964 mL 0.4820 mL 0.9641 mL 2.4102 mL
25 mM 0.0771 mL 0.3856 mL 0.7713 mL 1.9282 mL
30 mM 0.0643 mL 0.3214 mL 0.6427 mL 1.6068 mL
40 mM 0.0482 mL 0.2410 mL 0.4820 mL 1.2051 mL
50 mM 0.0386 mL 0.1928 mL 0.3856 mL 0.9641 mL
60 mM 0.0321 mL 0.1607 mL 0.3214 mL 0.8034 mL
80 mM 0.0241 mL 0.1205 mL 0.2410 mL 0.6026 mL
100 mM 0.0193 mL 0.0964 mL 0.1928 mL 0.4820 mL
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MX69-102 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MX69-1022925583-17-9MDM-2/p53Inhibitorinhibitorinhibit

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