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prolyl oligopeptidase

" in MedChemExpress (MCE) Product Catalog:

標的別:	Prolyl Endopeptidase (PREP) (16) Apoptosis (2) Drug Metabolite (2) Endogenous Metabolite (1) ERK (1) FAP (4) Fluorescent Dye (1) GLUT (1) Interleukin Related (2) JNK (2) MDM-2/p53 (2) Microtubule/Tubulin (1) NF-κB (2) Parasite (2) PPAR (2) Reference Standards (3) Ser/Thr Protease (2)
研究分野別:	Cancer (12) Cardiovascular Disease (3) Infection (3) Inflammation/Immunology (4) Metabolic Disease (5) Neurological Disease (3)

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Targets Recommended: Prolyl Endopeptidase (PREP) HIF/HIF Prolyl-Hydroxylase

製品番号	製品名	Target	研究分野	構造式

HY-100684

UAMC-1110 2 Publications Verification	Prolyl Endopeptidase (PREP) FAP	Cancer
UAMC-1110 is a highly potent and selective inhibitor of fibroblast activation protein (FAP) with an IC₅₀ of 3.2 nM. UAMC-1110 also inhibits prolyl oligopeptidase (PREP) with an IC₅₀ of 1.8 μM .

HY-N2481

Oroxylin A-7-O-glucuronide 1 Publications Verification Oroxyloside; Oroxylin A-7-O-β-D-glucuronide	Prolyl Endopeptidase (PREP) Drug Metabolite JNK PPAR NF-κB Interleukin Related	Cardiovascular Disease Metabolic Disease Inflammation/Immunology Cancer
Oroxylin A-7-O-glucuronide (oroxyloside) is an orally active flavonoid glucuronide and metabolite of Oroxylin A (HY-N0560). Oroxylin A-7-O-glucuronide can be extracted from the dried root of Scutellaria baicalensis. Oroxylin A-7-O-glucuronide exhibits **prolyl oligopeptidase inhibitory activity. Oroxylin A-7-O-glucuronide inhibits the JNK pathway, upregulates PPARγ, and inhibits NF-κB p65 nuclear translocation. Oroxylin A-7-O-glucuronide reduces cytokine (IL-1β, IL-6**) production. Oroxylin A-7-O-glucuronide exhibits anti-angiogenic, anti-tumor (glioma, liver cancer), anti-inflammatory, and hepatoprotective activities .

HY-100475

KYP-2047 1 Publications Verification	Apoptosis MDM-2/p53 Prolyl Endopeptidase (PREP)	Neurological Disease Inflammation/Immunology Cancer
KYP-2047 is a potent and BBB-penetrating prolyl-oligopeptidase (POP) inhibitor, with an K_i value of 0.023 nM. KYP-2047 reduces glioblastoma proliferation through angiogenesis and apoptosis modulation .

HY-145983

Suc-Gly-Pro-AMC 1 Publications Verification	FAP Prolyl Endopeptidase (PREP)	Cancer
Suc-Gly-Pro-AMC is a fluorescent substrate. Suc-Gly-Pro-AMC is a fibroblast activation protein (FAP) specific substrate. Suc-Gly-Pro-AMC reacts with recombinant porcine **prolyl oligopeptidase*. Suc-Gly-Pro-AMC can be used to study the activity of FAP, prolyl* endopeptidase (PREP). Suc-Gly-Pro-AMC is used in glioma research .

HY-139648

PREP inhibitor-1	Prolyl Endopeptidase (PREP)	Others
PREP inhibitor-1 (compound 27a) is a highly potent prolyl oligopeptidase (PREP) inhibitor (IC₅₀ < 1 nM).

HY-W404002

BR102910	Prolyl Endopeptidase (PREP)	Metabolic Disease
BR102910 is a selective fibroblast activation protein (FAP) inhibitor with the IC₅₀ of 2 nM. BR102910 also inhibits prolyl oligopeptidase (PREP) with the IC₅₀ of 49.00 μM. BR102910 can be used for the researchof type 2

HY-134454

Z-Pro-Pro-CHO	Prolyl Endopeptidase (PREP) Parasite	Infection
Z-Pro-Pro-CHO is a potent inhibitor of **prolyl oligopeptidase (POP*), with extremely high affinity for human prolyl* oligopeptidase (HsPOP) (IC₅₀=0.012 μM), and it also effectively inhibits the activity of Schistosoma mansoni prolyl oligopeptidase (SmPOP) (IC₅₀=0.16 μM). Z-Pro-Pro-CHO does not block the phosphorylation of ERK or the production of TNF-α or IFN-γ in immune cells from presensitized mice, nor does it induce harmful phenotypes in cultured Schistosoma mansoni schistosomula. Z-Pro-Pro-CHO only partially inhibits epithelial cell wound healing at extremely high concentrations. Z-Pro-Pro-CHO finds wide application in studies related to schistosomiasis .

HY-143475

POP-IN-2	Prolyl Endopeptidase (PREP)	Neurological Disease Cancer
POP-IN-2 (Compound 7k) is a potent, covalent prolyl oligopeptidase (POP) inhibitor with a K_i of 6 nM. POP-IN-2 can be used for studying neurodegenerative diseases and cancer .

HY-116828

ARI-3531	Prolyl Endopeptidase (PREP)	Cancer
ARI-3531 (compound 22) is a selective prolyl oligopeptidase (PREP) inhibitor (K_i=0.73 nM). ARI-3531 can be used to study tumor invasion and metastasis .

HY-N2481R

Oroxylin A-7-O-glucuronide (Standard) Oroxyloside (Standard); Oroxylin A-7-O-β-D-glucuronide (Standard)	Reference Standards Prolyl Endopeptidase (PREP) Drug Metabolite JNK PPAR NF-κB Interleukin Related	Cardiovascular Disease Metabolic Disease Inflammation/Immunology Cancer
Oroxylin A-7-O-glucuronide (Standard) is the analytical standard of Oroxylin A-7-O-glucuronide (HY-N2481). This product is intended for research and analytical applications. Oroxylin A-7-O-glucuronide (oroxyloside) is an orally active flavonoid glucuronide and metabolite of Oroxylin A (HY-N0560). Oroxylin A-7-O-glucuronide can be extracted from the dried root of Scutellaria baicalensis. Oroxylin A-7-O-glucuronide exhibits **prolyl oligopeptidase inhibitory activity. Oroxylin A-7-O-glucuronide inhibits the JNK pathway, upregulates PPARγ, and inhibits NF-κB p65 nuclear translocation. Oroxylin A-7-O-glucuronide reduces cytokine (IL-1β, IL-6**) production. Oroxylin A-7-O-glucuronide exhibits anti-angiogenic, anti-tumor (glioma, liver cancer), anti-inflammatory, and hepatoprotective activities .

HY-134454A

Z-Pro-prolinal N-Benzyloxycarbonyl-L-prolyl-L-prolinal	Prolyl Endopeptidase (PREP)	Cardiovascular Disease
Z-Pro-prolinal (N-Benzyloxycarbonyl-L-prolyl-L-prolinal) is a specific, orally active prolyl endopeptidase (PREP) inhibitor with an IC₅₀ of 0.4 nM for porcine PREP .

HY-143474

POP-IN-3	Prolyl Endopeptidase (PREP)	Neurological Disease Cancer
Y-29794 (Compound 2) is a potent, covalent prolyl oligopeptidase (POP) inhibitor with a K_i of 0.95 nM. Y-29794 can be used for studying neurodegenerative diseases and cancer .

HY-172207

POPTc80-IN-1	Ser/Thr Protease Parasite	Infection
POPTc80-IN-1 (Compound LC-45) is a competitive inhibitor for prolyl oligopeptidase of Trypanosoma cruzi POPTc80 with an IC₅₀ of 0.23 μM and a K_i of 0.054 μM. POPTc80-IN-1 inhibits the invasion of T. cruzi into host cell with an IC₅₀ of 46.71 μM .

HY-N16442

Pyrrocidine B	Endogenous Metabolite Prolyl Endopeptidase (PREP)	Cancer
Pyrrocidine B (Compound 6), an alkaloid, is a microbial secondary metabolite. Pyrrocidine B can be isolated from the endophytic fungus Neonectria ramulariae Wollenw KS-246. Pyrrocidine B has significant cytotoxicity against leukemia cells (IC₅₀ of 4.6  μM for HL60 cells) with a weak Prolyl oligopeptidase (POP) inhibitory activity .

HY-100475R

KYP-2047 (Standard)	Apoptosis Reference Standards MDM-2/p53 Prolyl Endopeptidase (PREP)	Cancer
KYP-2047 (Standard) is the analytical standard of KYP-2047 (HY-100475). This product is intended for research and analytical applications. KYP-2047 is a potent and BBB-penetrating prolyl-oligopeptidase (POP) inhibitor, with an Ki value of 0.023 nM. KYP-2047 reduces glioblastoma proliferation through angiogenesis and apoptosis modulation .

HY-100684R

UAMC-1110 (Standard)	Prolyl Endopeptidase (PREP) FAP Reference Standards	Cancer
UAMC-1110 (Standard) is the analytical standard of UAMC-1110 (HY-100684). This product is intended for research and analytical applications. UAMC-1110 is a highly potent and selective inhibitor of fibroblast activation protein (FAP) with an IC50 of 3.2 nM. UAMC-1110 also inhibits prolyl oligopeptidase (PREP) with an IC50 of 1.8 μM .

HY-P11367

Boc-Ala-Gly-Pro-Arg-AMC	Fluorescent Dye Ser/Thr Protease	Infection Metabolic Disease
Boc-Ala-Gly-Pro-Arg-AMC is a synthetic fluorescent substrate, widely used for the detection of protease activity. Boc-Ala-Gly-Pro-Arg-AMC can be used to detect the activity of serine proteases and the oligopeptide enzyme B of Trypanosoma brucei .

HY-182250

BR103354	FAP ERK GLUT	Metabolic Disease Inflammation/Immunology
BR103354 is an orally active, selective fibroblast activation protein (FAP) inhibitor with an IC₅₀ value of 14 nM against hFAP. BR103354 restores the levels of phosphorylated ERK and Glut1 that are reduced by co-treatment with hFGF21 and FAP, decreases non-fasting blood glucose concentrations, improves glucose tolerance, and reduces hepatic triglyceride content. BR103354 ameliorates hepatic steatosis and hepatic fibrosis. BR103354 can be used in the research of type 2 diabetes and non-alcoholic steatohepatitis .

HY-106021

Tasidotin ILX651 free base	Microtubule/Tubulin Prolyl Endopeptidase (PREP)	Cancer
Tasidotin (ILX651 free base) is a tubulin inhibitor and competitive Prolyl Endopeptidase (PREP) inhibitor, with an IC₅₀ of 10 μM against bovine tubulin. Tasidotin exhibits high cerebrospinal fluid penetration in non-human primates. Tasidotin antagonizes microtubule assembly and induces an extended assembly lag phase, thereby inhibiting mitosis and cell proliferation, and exerts cytotoxic and oncolytic effects on cancer cells. Tasidotin is metabolized into polypeptides and proline inside cells, and its in vivo metabolism is mediated by prolyl endopeptidase. Tasidotin can be applied in research related to Burkitt's lymphoma, breast cancer, leukemia, melanoma, central nervous system malignancies and various solid tumors .

製品番号	製品名	Target	研究分野

HY-134454

Z-Pro-Pro-CHO	Prolyl Endopeptidase (PREP) Parasite	Infection
Z-Pro-Pro-CHO is a potent inhibitor of **prolyl oligopeptidase (POP*), with extremely high affinity for human prolyl* oligopeptidase (HsPOP) (IC₅₀=0.012 μM), and it also effectively inhibits the activity of Schistosoma mansoni prolyl oligopeptidase (SmPOP) (IC₅₀=0.16 μM). Z-Pro-Pro-CHO does not block the phosphorylation of ERK or the production of TNF-α or IFN-γ in immune cells from presensitized mice, nor does it induce harmful phenotypes in cultured Schistosoma mansoni schistosomula. Z-Pro-Pro-CHO only partially inhibits epithelial cell wound healing at extremely high concentrations. Z-Pro-Pro-CHO finds wide application in studies related to schistosomiasis .

HY-P11367

Boc-Ala-Gly-Pro-Arg-AMC	Fluorescent Dye Ser/Thr Protease	Infection Metabolic Disease
Boc-Ala-Gly-Pro-Arg-AMC is a synthetic fluorescent substrate, widely used for the detection of protease activity. Boc-Ala-Gly-Pro-Arg-AMC can be used to detect the activity of serine proteases and the oligopeptide enzyme B of Trypanosoma brucei .

製品番号	製品名	Category	Target	構造式

HY-N2481

Oroxylin A-7-O-glucuronide 1 Publications Verification Oroxyloside; Oroxylin A-7-O-β-D-glucuronide	Structural Classification Monophenols Flavonoids Neurological Disease Classification of Application Fields Flavones Labiatae Phenols Plants Medicago truncatula Gaertn. Disease Research Fields Source Classification	Prolyl Endopeptidase (PREP) Drug Metabolite JNK PPAR NF-κB Interleukin Related
Oroxylin A-7-O-glucuronide (oroxyloside) is an orally active flavonoid glucuronide and metabolite of Oroxylin A (HY-N0560). Oroxylin A-7-O-glucuronide can be extracted from the dried root of Scutellaria baicalensis. Oroxylin A-7-O-glucuronide exhibits **prolyl oligopeptidase inhibitory activity. Oroxylin A-7-O-glucuronide inhibits the JNK pathway, upregulates PPARγ, and inhibits NF-κB p65 nuclear translocation. Oroxylin A-7-O-glucuronide reduces cytokine (IL-1β, IL-6**) production. Oroxylin A-7-O-glucuronide exhibits anti-angiogenic, anti-tumor (glioma, liver cancer), anti-inflammatory, and hepatoprotective activities .

HY-N2481R

Oroxylin A-7-O-glucuronide (Standard) Oroxyloside (Standard); Oroxylin A-7-O-β-D-glucuronide (Standard)	Monophenols Flavonoids Flavones Labiatae Phenols Plants Medicago truncatula Gaertn. Source Classification	Reference Standards Prolyl Endopeptidase (PREP) Drug Metabolite JNK PPAR NF-κB Interleukin Related
Oroxylin A-7-O-glucuronide (Standard) is the analytical standard of Oroxylin A-7-O-glucuronide (HY-N2481). This product is intended for research and analytical applications. Oroxylin A-7-O-glucuronide (oroxyloside) is an orally active flavonoid glucuronide and metabolite of Oroxylin A (HY-N0560). Oroxylin A-7-O-glucuronide can be extracted from the dried root of Scutellaria baicalensis. Oroxylin A-7-O-glucuronide exhibits **prolyl oligopeptidase inhibitory activity. Oroxylin A-7-O-glucuronide inhibits the JNK pathway, upregulates PPARγ, and inhibits NF-κB p65 nuclear translocation. Oroxylin A-7-O-glucuronide reduces cytokine (IL-1β, IL-6**) production. Oroxylin A-7-O-glucuronide exhibits anti-angiogenic, anti-tumor (glioma, liver cancer), anti-inflammatory, and hepatoprotective activities .

HY-N16442

Pyrrocidine B	Alkaloids Microorganisms Pyridine Alkaloids Source Classification	Endogenous Metabolite Prolyl Endopeptidase (PREP)
Pyrrocidine B (Compound 6), an alkaloid, is a microbial secondary metabolite. Pyrrocidine B can be isolated from the endophytic fungus Neonectria ramulariae Wollenw KS-246. Pyrrocidine B has significant cytotoxicity against leukemia cells (IC₅₀ of 4.6  μM for HL60 cells) with a weak Prolyl oligopeptidase (POP) inhibitory activity .

製品番号	Compare	製品名	Species	Source	Image

HY-P73692

	Prolyl Endopeptidase/PREP Protein, Mouse (sf9, His) prolyl endopeptidase; PE; Prep; Pep	Mouse	Sf9 insect cells
	The prolyl endopeptidase (PREP) protein is an enzyme capable of cleaving peptide bonds at the C-terminus of prolyl residues within peptides, particularly peptides up to about 30 amino acids in length.This enzymatic activity suggests a role for PREP in selective processing of peptides, particularly toward proline-containing substrates.Prolyl Endopeptidase/PREP Protein, Mouse (sf9, His) is the recombinant mouse-derived Prolyl Endopeptidase/PREP protein, expressed by Sf9 insect cells , with N-His labeled tag.

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