FAP

Fibroblast activation protein

Fibroblast activation protein (FAP) is a cell-surface serine protease that acts on various hormones and extracellular matrix components. FAP is highly upregulated in a wide variety of cancers, and is often used as a marker for pro-tumorigenic stroma.

FAP Inhibitors (5)

FAP Related Products (21):

Cat. No.	Product Name	Effect	Purity

HY-137331

FAPI-46		98.57%
FAPI-46 is a quinoline-based fibroblast activation protein (FAP)-targeted radiotracer. FAPI-46 has higher tumor uptake and prolonged tumor accumulation. FAPI-46 can be used for tumor imaging of a multitude of different cancers.

HY-128643

FAPI-4		98.42%
FAPI-4 is a potent fibroblast activation protein (FAP) inhibitor for the targeting FAP. FAPI-4 can be used in cancer research. ⁶⁸Ga-FAPI-4 PET/CT is a promising new diagnostic method for imaging various kinds of cancer, with good tumor-to-background contrast ratios.

HY-101801

Ac-Gly-BoroPro		≥98.0%
Ac-Gly-BoroPro is a selective FAP inhibitor with a K_i of 23 nM.

HY-147057

FAP-2286		99.04%
FAP-2286 is a potent and selective FAP-binding peptide coupled to a radionuclide chelator with a mean IC₅₀ value of 2.7 nM for binding to FAP. FAP-2286 can chelate radionuclides for imaging or therapeutic applications and has a strong effect on FAP-positive tumors. FAP-2286 can be used for FAP-positive tumor research.

HY-145938

OncoFAP		99.77%
OncoFAP is an ultra-high-affinity ligand of fibroblast activation protein (FAP) for targeting applications with pan-tumoral potential.

HY-153552A

NH2-UAMC1110 TFA	Inhibitor	99.89%
NH2-UAMC1110 TFA is a UAMC1110 derivative that can be used in the synthesis of FAPI-QS. UAMC1110 is a fibroblast activation protein (FAP) inhibitor. FAPI-QS is a chelating agent that can be used to synthesize high tumor selectivity and high dose radiotracers for the diagnosis and treatment of tumors.

HY-47979A

FAP-IN-2 TFA	Inhibitor	99.80%
FAP-IN-2 TFA is a ^99mTc-labeled isonitrile-containing FAP inhibitor derivative that can be used for tumor imaging.

HY-147173

FAPI-74
FAPI-74 is a PET (positron emission tomography) tracer targeting the fibroblast activation protein (FAP). FAPI-74 can be used for FAP-positive tumor research.

HY-P99269

Sibrotuzumab
Sibrotuzumab (BIBH 1) is a humanized IgG1 monoclonal antibody targets fibroblast activation protein (FAP). Sibrotuzumab can be used for the research of colorectal cancer and non-small cell lung cancer (NSCLC).

HY-145983

Suc-Gly-Pro-AMC		98.49%
Suc-Gly-Pro-AMC is a fibroblast activation protein (FAP)-specific substrate. Suc-Gly-Pro-AMC can be used to study the activity of FAP.

HY-139401

FAPI-34		99.67%
FAPI-34 is a fibroblast-activating protein (FAP) inhibitor with favorable pharmacokinetic and biochemical properties. (patent WO2019154886A1).

HY-136641

NOTA-FAPI	Inhibitor	99.26%
NOTA-FAPI is a fibroblast activation protein (FAP) inhibitor. NOTA-FAPI can be used as a probe for FAP-targeted tumour imaging. NOTA-FAPI has good tumour detection efficacy and excellent imaging quality.

HY-149860

FAP-IN-1	Inhibitor
FAP-IN-1 is a fibroblast activation protein (FAP) inhibitor with an IC₅₀ value of 3.3 nM. FAP-IN-1 can be used for the research of cancer.

HY-146180

FSDD0I
FSDD0I is an albumin-binding fibroblast activation protein (FAP) ligand. FSDD0I can be labeled with ⁶⁸Ga and ¹⁷⁷Lu for single photon emission computed tomography (SPECT) imaging.

HY-147057A

FAP-2286 acetate
FAP-2286 acetate is the conjugate of a fibroblast activation protein (FAP)-binding peptide. FAP-2286 acetate can be labeled with radionuclides for diagnostic applications. FAP-2286 acetate has antitumor activity.

HY-146181

FSDD1I
FSDD1I is an albumin-binding fibroblast activation protein (FAP) ligand. FSDD1I can be labeled with ⁶⁸Ga and ¹⁷⁷Lu for single photon emission computed tomography (SPECT) imaging.

HY-47979

FAP-IN-2	Inhibitor
FAP-IN-2 is a derivative of ^99mTc-labeled isonitrile-containing fibroblast activation protein (FAPI) inhibitor, that can be used for tumor imaging.

HY-148361

Fluorogen binding modulator-1
Fluorogen binding modulator-1 (PubChem SID 125240934) is a fluorogen activating protein (FAP)-fluorogen binding modulator with -log EC₅₀s of 6.61 and 6.37 for AM2.2-β2AR and AM2.2-GPR32, respectively.

HY-128642

FAPI-2
FAPI-2 is a fibroblast activation protein (FAP) inhibitor for cancer research.

HY-146182

FSDD3I
FSDD3I is an albumin-binding fibroblast activation protein (FAP) ligand. FSDD3I can be labeled with ⁶⁸Ga and ¹⁷⁷Lu for single photon emission computed tomography (SPECT) imaging.

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