2803421-14-7
Chemical Structure
3BP-3940
- CAS No.: 2803421-14-7
- Formula:C66H98N14O18S3
- Molecular Weight:1471.76
InChIKey: YIDMKSPNGLLPRM-YRXFYUGDSA-N
SMILES: O=C1[C@@]2([H])N(CCC2)C([C@H](CSCC3=CC(CSCCNC(CN4CCN(CCN(CCN(CC4)CC(O)=O)CC(O)=O)CC(O)=O)=O)=CC(CSC[C@H](NC([C@@H](NC([C@@H](NC([C@](NC([C@@]5([H])N1CCC5)=O)([H])[C@H](O)C)=O)CCC(N)=O)=O)CC6=CC=CC=C6)=O)C(O)=O)=C3)NC(NCCCC)=O)=O
Biological Activity: 3BP-3940 is a highly potent and selective peptide inhibitor of FAP that targets cancer-associated fibroblasts (CAFs) in the tumor microenvironment. 3BP-3940 can be labeled with radionuclides (such as Ga-68) for precise tumor imaging or Lu-177 for the development of targeted anticancer technologies. 3BP-3940 accumulates in tumor lesions and can be used to diagnose and inhibit various solid cancers and CAFs-related diseases[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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3BP-3940 | 99.49% | 3BP-3940 is a highly potent and selective peptide inhibitor of FAP that targets cancer-associated fibroblasts (CAFs) in the tumor microenvironment. 3BP-3940 can be labeled with radionuclides (such as Ga-68) for precise tumor imaging or Lu-177 for the development of targeted anticancer technologies. 3BP-3940 accumulates in tumor lesions and can be used to diagnose and inhibit various solid cancers and CAFs-related diseases. | ||||||||||||||||||||
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- [1]. Greifenstein L, et al. 3BP-3940, a highly potent FAP-targeting peptide for theranostics-production, validation and first in human experience with Ga-68 and Lu-177. iScience. 2023 Nov 23;26 (12) :108541. [Content Brief]
- [2]. Kramer C S, et al. FAP-Peptidvermittelte Radiorezeptortherapie (PTRT) bei soliden Tumoren: erste klinische Erfahrungen mit dem 177Lu-, 225Ac-oder 90Y-markierten Peptid 3BP-3940[J]. Nuklearmedizin-NuclearMedicine, 2023, 62 (02) : V14.
Keywords
