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FAPI-46 

Cat. No.: HY-137331
Handling Instructions

FAPI-46 is a quinoline-based fibroblast activation protein (FAP)-targeted radiotracer. FAPI-46 has higher tumor uptake and prolonged tumor accumulation. FAPI-46 can be used for tumor imaging of a multitude of different cancers.

For research use only. We do not sell to patients.

FAPI-46 Chemical Structure

FAPI-46 Chemical Structure

CAS No. : 2374782-04-2

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Description

FAPI-46 is a quinoline-based fibroblast activation protein (FAP)-targeted radiotracer. FAPI-46 has higher tumor uptake and prolonged tumor accumulation. FAPI-46 can be used for tumor imaging of a multitude of different cancers[1][2].

IC50 & Target

fibroblast activation protein (FAP)[1]

In Vitro

FAPI-46 (1-24 h) robustly binds to human FAP in human FAP-expressing HT-1080 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

FAPI-46 (i.v.) shows improved ratios of tumor to liver, kidney, and brain uptake, resulting in an enhanced image contrast for PET imaging[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

885.96

Formula

C₄₁H₅₇F₂N₁₁O₉

CAS No.

2374782-04-2

SMILES

O=C(C1=CC=NC(C=C2)=C1C=C2N(C)CCCN(CC3)CCN3C(CN(CCN(CC4)CC(O)=O)CCN(CCN4CC(O)=O)CC(O)=O)=O)NCC(N(CC5(F)F)[[email protected]@H](C5)C#N)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

FAPI-46FAPI46FAPI 46OthersquinolinefibroblastactivationproteinFAPradiotracertumorimagingcancerInhibitorinhibitorinhibit

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FAPI-46
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