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FAPI-46 

Cat. No.: HY-137331 Purity: 98.01% ee.: 100.00%
Handling Instructions

FAPI-46 is a quinoline-based fibroblast activation protein (FAP)-targeted radiotracer. FAPI-46 has higher tumor uptake and prolonged tumor accumulation. FAPI-46 can be used for tumor imaging of a multitude of different cancers.

For research use only. We do not sell to patients.

FAPI-46 Chemical Structure

FAPI-46 Chemical Structure

CAS No. : 2374782-04-2

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Description

FAPI-46 is a quinoline-based fibroblast activation protein (FAP)-targeted radiotracer. FAPI-46 has higher tumor uptake and prolonged tumor accumulation. FAPI-46 can be used for tumor imaging of a multitude of different cancers[1][2].

IC50 & Target

fibroblast activation protein (FAP)[1]

In Vitro

FAPI-46 (1-24 h) robustly binds to human FAP in human FAP-expressing HT-1080 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

FAPI-46 (i.v.) shows improved ratios of tumor to liver, kidney, and brain uptake, resulting in an enhanced image contrast for PET imaging[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

885.96

Formula

C₄₁H₅₇F₂N₁₁O₉

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 115 mg/mL (129.80 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1287 mL 5.6436 mL 11.2872 mL
5 mM 0.2257 mL 1.1287 mL 2.2574 mL
10 mM 0.1129 mL 0.5644 mL 1.1287 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 5.75 mg/mL (6.49 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 5.75 mg/mL (6.49 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
FAPI-46
Cat. No.:
HY-137331
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