[68Ga]Ga-FAPI-46 synthesis on a GAIA® module system: Thorough study of the automated radiolabeling reaction conditions

  • Appl Radiat Isot. 2024 Feb 1:206:111211. doi: 10.1016/j.apradiso.2024.111211.
Léa Rubira  1 ,  Charlotte Donzé  1 ,  Juliette Fouillet  1 ,  Benjamin Algudo  1 ,  Pierre Olivier Kotzki  2 ,  Emmanuel Deshayes  2 ,  Cyril Fersing  3
Affiliations
  • 1. Nuclear medicine department, Institut régional du Cancer de Montpellier (ICM), Univ. Montpellier, Montpellier, France.
  • 2. Nuclear medicine department, Institut régional du Cancer de Montpellier (ICM), Univ. Montpellier, Montpellier, France; Institut de Recherche en Cancérologie de Montpellier (IRCM), INSERM U1194, Univ. Montpellier, Institut régional du Cancer de Montpellier (ICM), Montpellier, France.
  • 3. Nuclear medicine department, Institut régional du Cancer de Montpellier (ICM), Univ. Montpellier, Montpellier, France; IBMM, Univ Montpellier, CNRS, ENSCM, Montpellier, France. Electronic address: [email protected].
PMID: 38309117 DOI: 10.1016/j.apradiso.2024.111211
Abstract

The influence of several parameters involved in the 68Ga radiolabeling of FAPI-46 was studied at the scale of the automated reaction. Among the buffers tested, HEPES 0.3 M pH 4 allowed both high radiochemical purity (RCP) and radiochemical yield (RCY), without prepurification of 68Ga but after final purification of [68Ga]Ga-FAPI-46 on a C18 cartridge. A longer reaction time did not show significant benefit on the RCP, while higher loads of FAPI-46 and gentisic acid as anti-radiolysis compound allowed better RCY.

Keywords
Automated production; FAPI-46; Fibroblast; Gallium-68; Molecular imaging; Radiochemistry.
Products
  • Cat. No.
    Product Name
    Description
    Target
    Research Area
  • HY-137331
    FAPI-46
    99.02%, FAP Tracer
    target: FAP
    Research Areas: Cancer