1432499-49-4
Chemical Structure
ARI-3099
- CAS No.: 1432499-49-4
- Formula:C13H18BN3O4
- Molecular Weight:291.11
IUPAC Name: ((R)-1-(isonicotinoyl-D-alanyl)pyrrolidin-2-yl)boronic acid
InChIKey: DRBWRJPFNOBNIO-KOLCDFICSA-N
SMILES: O=C(C1=CC=NC=C1)N[C@H](C)C(N2[C@@H](CCC2)B(O)O)=O
Biological Activity: ARI-3099 is an oral fibroblast activation protein (FAP) inhibitor. ARI-3099 specifically inhibits the proteolytic activity of FAP and blocks the cleavage of human FGF-21 between residues P171 and S172. ARI-3099 extends the half-life of circulating human FGF-21 in mice. ARI-3099 can be used in the research of type 2 diabetes and metabolic disorders[1].
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ARI-3099 | 99.95% | ARI-3099 is an oral fibroblast activation protein (FAP) inhibitor. ARI-3099 specifically inhibits the proteolytic activity of FAP and blocks the cleavage of human FGF-21 between residues P171 and S172. ARI-3099 extends the half-life of circulating human FGF-21 in mice. ARI-3099 can be used in the research of type 2 diabetes and metabolic disorders. | ||||||||||||||||||||
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Keywords
