80049-85-0
Chemical Structure
Suc-Gly-Pro-AMC
- CAS No.: 80049-85-0
- Formula:C21H23N3O7
- Molecular Weight:429.42
IUPAC Name: (S)-4-((2-(2-((4-methyl-2-oxo-2H-chromen-7-yl)carbamoyl)pyrrolidin-1-yl)-2-oxoethyl)amino)-4-oxobutanoic acid
InChIKey: NKEPCOOQNLGSLJ-HNNXBMFYSA-N
SMILES: CC(C1=CC=C(NC([C@H]2N(CCC2)C(CNC(CCC(O)=O)=O)=O)=O)C=C1O3)=CC3=O
Biological Activity: Suc-Gly-Pro-AMC is a fluorescent substrate. Suc-Gly-Pro-AMC is a fibroblast activation protein (FAP) specific substrate. Suc-Gly-Pro-AMC reacts with recombinant porcine prolyl oligopeptidase. Suc-Gly-Pro-AMC can be used to study the activity of FAP, prolyl endopeptidase (PREP). Suc-Gly-Pro-AMC is used in glioma research[1][2][3].
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Suc-Gly-Pro-AMC | 99.85% | Suc-Gly-Pro-AMC is a fluorescent substrate. Suc-Gly-Pro-AMC is a fibroblast activation protein (FAP) specific substrate. Suc-Gly-Pro-AMC reacts with recombinant porcine prolyl oligopeptidase. Suc-Gly-Pro-AMC can be used to study the activity of FAP, prolyl endopeptidase (PREP). Suc-Gly-Pro-AMC is used in glioma research. | ||||||||||||||||||||
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- [1]. Zhang B, et, al. A cell-based fluorescent assay for FAP inhibitor discovery. Bioorg Med Chem Lett. 2020 Jul 15;30(14):127253. [Content Brief]
- [2]. Jiang D, et al. Prolyl Endopeptidase Gene Disruption Improves Gut Dysbiosis and Non-alcoholic Fatty Liver Disease in Mice Induced by a High-Fat Diet. Front Cell Dev Biol. 2021 May 20;9:628143. [Content Brief]
- [3]. Venäläinen JI, et al. Substrate-dependent, non-hyperbolic kinetics of pig brain prolyl oligopeptidase and its tight binding inhibition by JTP-4819. Biochem Pharmacol. 2002 Aug 1;64(3):463-71. [Content Brief]
Keywords
