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Cat. No.: HY-N16442

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Pyrrocidine B

Pyrrocidine B (Compound 6), an alkaloid, is a microbial secondary metabolite. Pyrrocidine B can be isolated from the endophytic fungus Neonectria ramulariae Wollenw KS-246. Pyrrocidine B has significant cytotoxicity against leukemia cells (IC₅₀ of 4.6  μM for HL60 cells) with a weak Prolyl oligopeptidase (POP) inhibitory activity.

For research use only. We do not sell to patients.

CAS No.: 428439-25-2
Formula: C₃₁H₃₉NO₄
Molecular Weight:489.65

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

Pyrrocidine B Chemical Structure

CAS No.: 428439-25-2

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All Endogenous Metabolite Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HL-60	IC₅₀	6.92 μM Compound: 4	Cytotoxicity against human HL60 cells by MTT assay Cytotoxicity against human HL60 cells by MTT assay	[PMID: 18952424]
K562	IC₅₀	8.64 μM Compound: 4	Cytotoxicity against human K562 cells by MTT assay Cytotoxicity against human K562 cells by MTT assay	[PMID: 18952424]
LNCaP	IC₅₀	11.74 μM Compound: 4	Cytotoxicity against human LNCAP cells by MTT assay Cytotoxicity against human LNCAP cells by MTT assay	[PMID: 18952424]

Chemical Information

CAS No. 428439-25-2
Molecular Weight 489.65
Formula C₃₁H₃₉NO₄
SMILES

C[C@]1(C[C@@H]2C)[C@](C(C)=C3)([H])[C@]([C@](C([C@](C(N4)=O)([H])C[C@@]4(C5)O)=O)([H])[C@@H]3C=C)([H])[C@@](OC6=CC=C5C=C6)([H])[C@]1([H])[C@H](C2)C
Structure Classification
- Alkaloids
- Pyridine Alkaloids
Initial Source
- Microorganisms
Neonectria ramulariae
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Shiono Y, et al. A dimeric pyrrocidine from Neonectria ramulariae is an inhibitor of prolyl oligopeptidase[J]. Phytochemistry Letters, 2012, 5(1): 91-95.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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Pyrrocidine B

All Endogenous Metabolite Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Pyrrocidine B Related Classifications

HY-N16442 Related Classifications