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Results for "

pyrimidine compound

" in MedChemExpress (MCE) Product Catalog:

46

Inhibitors & Agonists

1

Screening Libraries

8

Biochemical Assay Reagents

4

Natural
Products

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-10520
    CGP 57380
    3 Publications Verification

    		 MNK Apoptosis Cancer
    CGP 57380 is a cell-permeable pyrazolo-pyrimidine compound that acts as a selective inhibitor of Mnk1 with IC50 of 2.2 μM, but has no inhibitory activity against p38, JNK1, ERK1/2, PKC, or Src-like kinases.
    CGP 57380
  • HY-10322
    Falnidamol
    4 Publications Verification

    BIBX 1382

    		 EGFR Cancer
    Falnidamol (BIBX 1382) is an orally active, selective EGFR tyrosine kinase inhibitor with an IC50 of 3 nM. Falnidamol displays > 1000-fold lower potency against ErbB2 (IC50=3.4 μM) and a range of other related tyrosine kinases (IC50>10 μM). Falnidamol is a pyrimido-pyrimidine compound and has anti-cancer activity .
    Falnidamol
  • HY-78428
    CDK-IN-6

    		CDK Cancer
    CDK-IN-6, a class of pyrazolo[1,5-a]pyrimidine compound, is a CDK inhibitor with anticancer activities .
    CDK-IN-6
  • HY-171932
    CaMKIIδ-IN-1

    		CaMK Cardiovascular Disease
    CaMKIIδ-IN-1 (Compound 15e) is a pyrimidine-based inhibitor of CaMKIIδ with an IC50 of 12 nM .
    CaMKIIδ-IN-1
  • HY-Y1298
    Methyl acetylacetate
    1 Publications Verification

    Acetoacetate methyl ester; Methyl 3-oxobutanoate; Methyl acetoacetate

    		 Endogenous Metabolite Metabolic Disease Inflammation/Immunology
    Methyl acetylacetate is a chemical reagent used in the synthesis of pharmaceuticals for the synthesis of α-substituted acetoacetate and cyclic compounds such as pyrazole, pyrimidine, and coumarin derivatives. Methyl acetoacetate can be used in the study of inflammatory diseases .
    Methyl acetylacetate
  • HY-Y0519
    Pyrimidine

    		Endogenous Metabolite Neurological Disease Cancer
    Pyrimidine is a nitrogen-containing heterocyclic compound and endogenous metabolite. Pyrimidine derivatives can be used in pancreatic cancer, triple-negative breast cancer, colon carcinoma and neuron research .
    Pyrimidine
  • HY-W018744
    4-Amino-2,6-dichloropyrimidine

    		Biochemical Assay Reagents Others
    2,6-Dichloro pyrimidine -4-amine is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
    4-Amino-2,6-dichloropyrimidine
  • HY-18622
    PP58

    		Src FGFR PDGFR Cancer
    PP58 is a pyrido[2,3-d]pyrimidine-based compound that inhibits PDGFR, FGFR and Src family activities with nanomolar IC50 values.
    PP58
  • HY-40350
    2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine

    		Biochemical Assay Reagents Others
    2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
    2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine
  • HY-135282
    DHODH-IN-1

    		Dihydroorotate Dehydrogenase DNA/RNA Synthesis Infection
    DHODH-IN-1 (compound 18d) is a potent Dihydroorotate Dehydrogenase (DHODH) inhibitor with an IC50 of 25 nM. DHODH-IN-1 is an inhibitor of pyrimidine biosynthesis pathway .
    DHODH-IN-1
  • HY-59303
    1H-Imidazole-5-carboxaldehyde

    		Biochemical Assay Reagents Others
    1H-Imidazole-5-carboxaldehyde can be used as a chemical reagent in organic synthesis reactions. 1H-Imidazole-5-carboxaldehyde can be used to prepare other imidazole compounds, such as imidazole pyrimidine and imidazolone. 1H-Imidazole-5-carboxaldehyde can also be used as biochemical dyes and fluorescent probes.
    1H-Imidazole-5-carboxaldehyde
  • HY-W002404
    Pyrimidine-4-carboxylic acid

    		Biochemical Assay Reagents Others
    Pyrimidine-4-carboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
    Pyrimidine-4-carboxylic acid
  • HY-W140956
    3-Methyluracil

    		Drug Intermediate Others
    3-Methyluracil is a pyrimidine heterocyclic compound that can serve as an intermediate. 3-Methyluracil can be isolated from Cordyceps bassiana .
    3-Methyluracil
  • HY-42451
    2-Chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxaldehyde

    		Drug Intermediate Others
    2-Chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxaldehyde is a drug intermediate for synthesis of various active compounds.
    2-Chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxaldehyde
  • HY-42450
    2-Chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidine-6-methanol

    (2-Chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)methanol

    		 Drug Intermediate Others
    2-Chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidine-6-methanol ((2-Chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)methanol) is a drug intermediate for synthesis of various active compounds.
    2-Chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidine-6-methanol
  • HY-32746
    5-Bromo-2-fluoropyridine

    		Biochemical Assay Reagents Others
    5-Bromo-2-fluoropyridine is a biochemical reagent that can be used as a biological material or organic compound for life science related research. 5-Bromo-2-fluoropyridine easily reacts with amines to synthesize halogenated pyridine and pyrimidine. 5-Bromo-2-fluoropyridine can be used as a model substrate to explore their efficiency and selectivity through successive SNAr substitution reactions and transition-metal-catalyzed cross-coupling reaction without an intervening purification step .
    5-Bromo-2-fluoropyridine
  • HY-Y0519R
    Pyrimidine (Standard)

    		Reference Standards Endogenous Metabolite Metabolic Disease
    Pyrimidine (Standard) is the analytical standard of Pyrimidine. This product is intended for research and analytical applications. Pyrimidine is a nitrogen-containing heterocyclic compound and endogenous metabolite. Pyrimidine derivatives can be used in pancreatic cancer, triple-negative breast cancer, colon carcinoma and neuron research .
    Pyrimidine (Standard)
  • HY-20176
    2,4-Dichlorothieno[3,2-d]pyrimidine

    		Drug Intermediate Adenosine Receptor PI3K Infection
    2,4-Dichlorothieno[3,2-d]pyrimidine is a thienopyrimidine scaffold and a key synthetic precursor, which is widely used for constructing 4-arylthieno[3,2-d]pyrimidine compounds. 2,4-Dichlorothieno[3,2-d]pyrimidine serves for the development of 4-arylthieno[3,2-d]pyrimidine-based human adenosine A2a receptor antagonists, as well as thienopyrimidine-based PI3K-α inhibitors. In addition, 2,4-Dichlorothieno[3,2-d]pyrimidine has potential application value in studies related to whipworm disease .
    2,4-Dichlorothieno[3,2-d]pyrimidine
  • HY-149365
    SIKs-IN-1

    		Salt-inducible Kinase (SIK) Inflammation/Immunology
    SIKs-IN-1 (compound 8h), a pyrimidine-5-carboxamide derivative, is a Salt-inducible kinases (SIKs) inhibitor. SIKs regulates the transformation of M1/M2 macrophages, involving in inflammation process. SIKs-IN-1 inhibits SIK activity, up-regulates anti-inflammatory cytokine IL-10, but down-regulates pro-inflammatory cytokine IL-12. SIKs-IN-1 shows excellent anti-inflammatory effects in a DSS-induced colitis model .
    SIKs-IN-1
  • HY-44072
    7-Chloro-6-fluoro-1-(2-isopropyl-4-methyl-3-pyridyl)pyrido[2,3-d]pyrimidine-2,4-dione

    		Drug Intermediate Others
    7-Chloro-6-fluoro-1-(2-isopropyl-4-methyl-3-pyridyl)pyrido[2,3-d]pyrimidine-2,4-dione is a drug intermediate for synthesis of various active compounds.
    7-Chloro-6-fluoro-1-(2-isopropyl-4-methyl-3-pyridyl)pyrido[2,3-d]pyrimidine-2,4-dione
  • HY-112505
    Efflux inhibitor-1

    		BCRP Cancer
    Efflux inhibitor-1 (compound 2) is a pyrazolo[1,5-a]pyrimidine efflux inhibitor. Efflux inhibitor-1 selectively targets toward ABCG2/BCRP over ABCB1 with IC50s of 0.45 μM and 2.17 μM, respectively .
    Efflux inhibitor-1
  • HY-78337
    Methyl pyrimidine-2-carboxylate

    		Biochemical Assay Reagents Others
    Methyl pyrimidine-2-carboxylate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
    Methyl pyrimidine-2-carboxylate
  • HY-171932A
    CaMKIIδ-IN-1 hydrochloride

    		CaMK Cardiovascular Disease
    CaMKIIδ-IN-1 (Compound 15e) hydrochloride is a pyrimidine-based inhibitor of CaMKIIδ with an IC50 of 12 nM .
    CaMKIIδ-IN-1 hydrochloride
  • HY-148832
    BTK-IN-20

    		Btk Inflammation/Immunology Cancer
    BTK-IN-20 (compound 283) is a BTK tyrosine kinase inhibitor and a 1H-pyrazolo[3,4-d]pyrimidine derivative. BTK-IN-20 can be used for the research of cancer and inflammation .
    BTK-IN-20
  • HY-164151
    ERK-IN-8

    		ERK Cancer
    ERK-IN-8 (compound I-1) is an aniline pyrimidine derivative that acts as an ERK inhibitor. ERK-IN-8 has a strong inhibitory effect on ERK2 in vitro (IC50≤50 nM). ERK-IN-8 can be used in cancer research .
    ERK-IN-8
  • HY-78248
    4-(1H-Pyrazol-4-yl)-7-[[2-(trimethylsilyl)ethoxy]methyl]-7H-pyrrolo[2,3-d]pyrimidine

    		Biochemical Assay Reagents Others
    4-(1H-Pyrazol-4-yl)-7-[[2-(trimethylsilyl)ethoxy]methyl]-7H-pyrrolo[2,3-d]pyrimidine is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
    4-(1H-Pyrazol-4-yl)-7-[[2-(trimethylsilyl)ethoxy]methyl]-7H-pyrrolo[2,3-d]pyrimidine
  • HY-176914
    Myosin-IN-3

    		Ferroptosis Myosin Cardiovascular Disease Inflammation/Immunology
    Myosin-IN-3 (Compound 4-1) is a pyrimidine ketone derivative. Myosin-IN-3 exhibits significant anti ferroptotic activity (IC50 = 3.11 μM) while possessing myosin (IC50 = 3.09 μM) inhibitory activity and antioxidant activity (DPPH EC50 = 23.17 μM; MDA EC50 = 55.34 μM). Myosin-IN-3 can be used for research on heart conditions such as hypertrophic cardiomyopathy .
    Myosin-IN-3
  • HY-176063
    TRPV1 antagonist 11

    		TRP Channel Opioid Receptor Neurological Disease
    TRPV1 antagonist 11 (compound 2ac) is a potent TRPV1 antagonist with an IC50 of 29.3 nM. TRPV1 antagonist 11 is a potent μ-opioid receptor (MOR) agonist with a Ki of 60.3 nM. TRPV1 antagonist 11, a pyrimidine piperazine, exhibits pain relieving effects by antagonizing TRPV1 and stimulating MOR. TRPV1 antagonist 11 shows a potent, dose-dependent anti-nociceptive effect in a Formalin-induced pain model in mice .
    TRPV1 antagonist 11
  • HY-161071
    Antioxidant/anticancer agent 1

    		Fungal Infection Cancer
    Antioxidant/anticancer agent 1 (compound 5) is a pyrimidine-derivatized Schiff base based on pyrimidine hydroxy-1-naphthaldehyde and has antibacterial, antioxidant, antifungal, and anticancer properties. Antioxidant/anticancer agent 1 .
    Antioxidant/anticancer agent 1
  • HY-118295
    Pyrimidine-indole hybrid

    		Endogenous Metabolite Cancer
    Pyrimidine-indole hybrid is a compound that inhibits ciliogenesis and has the activity of antagonizing the Hedgehog signaling pathway by destabilizing microtubules. Pyrimidine-indole hybrid exerts its biological effects by inhibiting ciliogenesis and deconstructing the stable form of α-tubulin. Pyrimidine-indole hybrid has shown its unique mechanism of action in in vitro cell experiments and zebrafish embryo models, interfering with microtubule dynamics .
    Pyrimidine-indole hybrid
  • HY-167828
    ARN25062

    		Ras Cancer
    ARN25062 (compound 27) is a CDC42/RHOJ inhibitor with antitumor activity. ARN25062 is a novel trisubstituted pyrimidine derivative .
    ARN25062
  • HY-157311
    α-Glucosidase-IN-45

    		Glycosidase Cancer
    α-Glucosidase-IN-45 (compound 11E) is an inhibitor of α-glucosidase. α-Glucosidase-IN-45 is a novel indol-fused pyrano[2,3-D]pyrimidine compound .
    α-Glucosidase-IN-45
  • HY-139364
    mPGES1-IN-4

    		PGE synthase Others
    mPGES1-IN-4 (compound 32) is a polysubstituted pyrimidine compound and a submicromolar PGE2 production inhibitor. It exerts its anti-inflammatory effect mainly by inhibiting mPGES-1 and has a significant inhibitory effect on the acute inflammation model in vivo.
    mPGES1-IN-4
  • HY-139365
    mPGES1-IN-5

    		PGE synthase Others
    mPGES1-IN-5 (compound 18) is a polysubstituted pyrimidine compound and a submicromolar PGE2 production inhibitor. It exerts its anti-inflammatory effect mainly by inhibiting mPGES-1 and has a significant inhibitory effect on the acute inflammation model in vivo.
    mPGES1-IN-5
  • HY-43791
    4-Amino-6-bromo-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile

    		Drug Intermediate Others
    4-Amino-6-bromo-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile is a drug intermediate for synthesis of various active compounds.
    4-Amino-6-bromo-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
  • HY-139974
    BChE-IN-2

    		Cholinesterase (ChE) Neurological Disease
    BChE-IN-2 (compound 22) is a potent inhibitor of BChE with a Ki of 0.099 μM. BChE-IN-2 is a pyrimidine and pyridine derivative. BChE-IN-2 has the potential for the research of Alzheimer’s disease (AD) .
    BChE-IN-2
  • HY-155761
    Antifungal agent 71

    		Fungal Infection
    Antifungal agent 71 (compound 6r) is a trifluoromethyl pyrimidine derivative with antifungal activity. Antifungal agent 71 exhibits good in vitro antifungal activity against F. oxysporum, with the EC50 value of 3.61 μg/mL .
    Antifungal agent 71
  • HY-W158234
    N-Methylbenzo[d]oxazol-2-amine

    		Parasite Infection
    N-Methylbenzo[d]oxazol-2-amine (compound 1) is an anthelmintic activity and lower cytotoxicity against T. spiralis adult worm. N-Methylbenzo[d]oxazol-2-amine up-regulates the metabolism of purine, pyrimidine and down-regulates sphingolipid metabolism .
    N-Methylbenzo[d]oxazol-2-amine
  • HY-158177
    EGFR T790M/L858R-IN-6

    		EGFR Cancer
    EGFR T790M/L858R-IN-6 (compound 53), a pyrimidine compound, is a potent EGFR T790M/L858R inhibitor. EGFR T790M/L858R-IN-6 shows 90.88% enzyme activity inhibition with 0.05 μM .
    EGFR T790M/L858R-IN-6
  • HY-158178
    EGFR T790M/L858R-IN-7

    		EGFR Cancer
    EGFR T790M/L858R-IN-7 (Compound 72) is a novel pyrimidine compound that inhibits the EGFR T790M and L858R mutation with a high efficacy (93% inhibition rate at 0.05 μM). EGFR T790M/L858R-IN-7 functions by specifically binding to the kinase domain of EGFR, thereby inhibiting its phosphorylation activity .
    EGFR T790M/L858R-IN-7
  • HY-161067
    EGFR-IN-96

    		EGFR Apoptosis Cancer
    EGFR-IN-96 (compound 7a) is a thieno[2,3-d]pyrimidine EGFR inhibitor that can induce apoptosis. EGFR-IN-96 arrests the growth of HepG2 cells in the S phase and G2/M phase, and inhibits the growth of cancer cells bearing EGFR wild-type and EGFR T790M .
    EGFR-IN-96
  • HY-10322R
    Falnidamol (Standard)

    BIBX 1382 (Standard)

    		 Reference Standards EGFR Cancer
    Falnidamol (Standard) is the analytical standard of Falnidamol. This product is intended for research and analytical applications. Falnidamol (BIBX 1382) is an orally active, selective EGFR tyrosine kinase inhibitor with an IC50 of 3 nM. Falnidamol displays > 1000-fold lower potency against ErbB2 (IC50=3.4 μM) and a range of other related tyrosine kinases (IC50>10 μM). Falnidamol is a pyrimido-pyrimidine compound and has anti-cancer activity .
    Falnidamol (Standard)
  • HY-161824
    Antiproliferative agent-52

    		Drug Intermediate Microtubule/Tubulin Cancer
    Antiproliferative agent-52 is a tubulin inhibitor with a porcine tubulin KD of 29.65 μM. Antiproliferative agent-52 binds to the colchicine-binding site at the α-tubulin and β-tubulin interface and inhibits tubulin polymerization. Antiproliferative agent-52 exhibits antiproliferative activity against tumor cells. Antiproliferative agent-52 serves as a lead compound for development of thienopyrimidine and heterocyclic fused pyrimidines with antiproliferative activity. Antiproliferative agent-52 can be used for the research of ovarian cancer, non-small cell lung cancer .
    Antiproliferative agent-52
  • HY-155817
    UNC7096

    		Histone Methyltransferase Others
    UNC7096 (compound 53) is a biotinylated affinity reagent. The phenyl ring of UNC7096 replaces the pyrimidine ring in UNC6934 (HY-145103) and introduces biotin at the para position of the phenyl ring, which has a high binding affinity to the NSD2-PWWP1 domain (Kd=46 nM). UNC7096 blocks the interaction between NSD2-PWWP1 and nucleosomal H3K36me2 by occupying the methyl-lysine binding pocket of NSD2-PWWP1. This binding is achieved by covalent binding through the formation of hydrogen bonds and a specific aromatic cage structure. UNC7096 can be used to capture proteins that interact with the NSD2-PWWP1 domain to further analyze the biological significance of these interactions .
    UNC7096
  • HY-178216
    Glycosidase-IN-3

    		Glycosidase Neurological Disease
    Glycosidase-IN-3 (example 92) is a pyrimidine compound targeting beta-glucocerebrosidase, which can be used in the research of related diseases such as Gaucher's disease and Parkinson's disease .
    Glycosidase-IN-3
  • HY-10520R
    CGP 57380 (Standard)

    		Reference Standards MNK Apoptosis Cancer
    CGP 57380 (Standard) is the analytical standard of CGP 57380 (HY-10520). This product is intended for research and analytical applications. CGP 57380 is a cell-permeable pyrazolo-pyrimidine compound that acts as a selective inhibitor of Mnk1 with IC50 of 2.2 μM, but has no inhibitory activity against p38, JNK1, ERK1/2, PKC, or Src-like kinases.
    CGP 57380 (Standard)

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