1. Metabolic Enzyme/Protease Cell Cycle/DNA Damage
  2. Dihydroorotate Dehydrogenase DNA/RNA Synthesis
  3. DHODH-IN-1

DHODH-IN-1 (compound 18d) is a potent Dihydroorotate Dehydrogenase (DHODH) inhibitor with an IC50 of 25 nM. DHODH-IN-1 is an inhibitor of pyrimidine biosynthesis pathway.

For research use only. We do not sell to patients.

DHODH-IN-1 Chemical Structure

DHODH-IN-1 Chemical Structure

CAS No. : 1800296-63-2

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Based on 1 publication(s) in Google Scholar

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Description

DHODH-IN-1 (compound 18d) is a potent Dihydroorotate Dehydrogenase (DHODH) inhibitor with an IC50 of 25 nM. DHODH-IN-1 is an inhibitor of pyrimidine biosynthesis pathway[1].

IC50 & Target

IC50: 25 nM (DHODH)[1]

In Vitro

DHODH-IN-1 (compound 18d) strongly inhibits Jurkat cells proliferation (IC50=0.02 μM)[1].
DHODH-IN-1 (4, 20, 100 nM) blocks the measles virus replication in cells[1].
DHODH-IN-1 (0.008, 0.04, 0.2, 1, 5 μM) increases the expression of an ISRE-luciferase reporter gene when transfecting cells with ssRNA molecules[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: Jurkat cells
Concentration: 0.00001, 0.0001, 0.001, 0.01, 0.1, 1, 10 μM
Incubation Time: 72 hours
Result: Strongly inhibited Jurkat cells proliferation (IC50=0.02 μM).
In Vivo

DHODH-IN-1 (compound 18d) has a t1/2 of 27–41 min[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

403.40

Formula

C21H20F3N3O2

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

FC1=CC(C2CC2)=CN=C1N3N=C(OC(C)C)C(OC4=C(F)C=CC=C4F)=C3C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
DHODH-IN-1
Cat. No.:
HY-135282
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