2,4-Dichlorothieno[3,2-d]pyrimidine
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2,4-Dichlorothieno[3,2-d]pyrimidine is a thienopyrimidine scaffold and a key synthetic precursor, which is widely used for constructing 4-arylthieno[3,2-d]pyrimidine compounds. 2,4-Dichlorothieno[3,2-d]pyrimidine serves for the development of 4-arylthieno[3,2-d]pyrimidine-based human adenosine A2a receptor antagonists, as well as thienopyrimidine-based PI3K-α inhibitors. In addition, 2,4-Dichlorothieno[3,2-d]pyrimidine has potential application value in studies related to whipworm disease.
For research use only. We do not sell to patients.
- CAS No.: 16234-14-3
- Formula: C6H2Cl2N2S
- Molecular Weight:205.06
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
All Adenosine Receptor Isoforms
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CCRF-CEM | IC50 |
5.2 μM
Compound: 1
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Cytotoxicity against human CCRF-CEM cells assessed as reduction in cell number after 72 hrs by cell counting assay
Cytotoxicity against human CCRF-CEM cells assessed as reduction in cell number after 72 hrs by cell counting assay
|
[PMID: 24631358] |
| HeLa | IC50 |
3.9 μM
Compound: 1
|
Cytotoxicity against human HeLa cells assessed as reduction in cell number after 72 hrs by cell counting assay
Cytotoxicity against human HeLa cells assessed as reduction in cell number after 72 hrs by cell counting assay
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[PMID: 24631358] |
| L1210 | IC50 |
0.32 μM
Compound: 1
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Cytotoxicity against mouse L1210 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity against mouse L1210 cells assessed as reduction in cell viability after 48 hrs by MTT assay
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[PMID: 24631358] |
| L1210 | IC50 |
0.67 μM
Compound: 1
|
Cytotoxicity against mouse L1210 cells assessed as reduction in cell number after 48 hrs by cell counting assay
Cytotoxicity against mouse L1210 cells assessed as reduction in cell number after 48 hrs by cell counting assay
|
[PMID: 24631358] |
| MDA-MB-231 | IC50 |
9 μM
Compound: 1
|
Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay
Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay
|
[PMID: 25791452] |
Chemical Information
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CAS No. 16234-14-3
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Appearance Solid
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Molecular Weight 205.06
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Formula C6H2Cl2N2S
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Color Off-white to light yellow
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SMILES
ClC=1N=C(Cl)C=2SC=CC2N1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[2]. Gillespie RJ, et al. Antagonists of the human adenosine A2A receptor. Part 2: Design and synthesis of 4-arylthieno[3,2-d]pyrimidine derivatives. Bioorg Med Chem Lett. 2008;18(9):2920-2923. [Content Brief]
[3]. Mohammed S, et al. Discovery of 2-(4-Ureido-piperidin-1-yl)-4-morpholinothieno [3,2-D] Pyrimidines as Orally Bioavailable Phosphoinositide-3-Kinase Inhibitors with In Vitro and In Vivo Antitumor Efficacy in Triple-Negative Breast Cancer. J Med Chem. 2025;68(20):21282-21317. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)