16234-14-3
![2,4-Dichlorothieno[3,2-d]pyrimidine Chemical Structure](http://file.medchemexpress.cn/product_pic/hy-20176.gif "2,4-Dichlorothieno[3,2-d]pyrimidine Chemical Structure")
Chemical Structure
2,4-Dichlorothieno[3,2-d]pyrimidine
- CAS No.: 16234-14-3
- Formula:C6H2Cl2N2S
- Molecular Weight:205.06
IUPAC Name: 2,4-dichlorothieno[3,2-d]pyrimidine
InChIKey: AQECFYPZMBRCIA-UHFFFAOYSA-N
SMILES: ClC=1N=C(Cl)C=2SC=CC2N1
Biological Activity: 2,4-Dichlorothieno[3,2-d]pyrimidine is a thienopyrimidine scaffold and a key synthetic precursor, which is widely used for constructing 4-arylthieno[3,2-d]pyrimidine compounds. 2,4-Dichlorothieno[3,2-d]pyrimidine serves for the development of 4-arylthieno[3,2-d]pyrimidine-based human adenosine A2a receptor antagonists, as well as thienopyrimidine-based PI3K-α inhibitors. In addition, 2,4-Dichlorothieno[3,2-d]pyrimidine has potential application value in studies related to whipworm disease[1][2][3].
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2,4-Dichlorothieno[3,2-d]pyrimidine | 2,4-Dichlorothieno[3,2-d]pyrimidine is a thienopyrimidine scaffold and a key synthetic precursor, which is widely used for constructing 4-arylthieno[3,2-d]pyrimidine compounds. 2,4-Dichlorothieno[3,2-d]pyrimidine serves for the development of 4-arylthieno[3,2-d]pyrimidine-based human adenosine A2a receptor antagonists, as well as thienopyrimidine-based PI3K-α inhibitors. In addition, 2,4-Dichlorothieno[3,2-d]pyrimidine has potential application value in studies related to whipworm disease. | |||||||||||||||||||||
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References
- [1]. Partridge F A, et al. 2, 4-Diaminothieno [3, 2-d] pyrimidines, a new class of anthelmintic with activity against adult and egg stages of whipworm[J]. PLoS neglected tropical diseases, 2018, 12(7): e0006487.
- [2]. Gillespie RJ, et al. Antagonists of the human adenosine A2A receptor. Part 2: Design and synthesis of 4-arylthieno[3,2-d]pyrimidine derivatives. Bioorg Med Chem Lett. 2008;18(9):2920-2923. [Content Brief]
- [3]. Mohammed S, et al. Discovery of 2-(4-Ureido-piperidin-1-yl)-4-morpholinothieno [3,2-D] Pyrimidines as Orally Bioavailable Phosphoinositide-3-Kinase Inhibitors with In Vitro and In Vivo Antitumor Efficacy in Triple-Negative Breast Cancer. J Med Chem. 2025;68(20):21282-21317. [Content Brief]
