Sexangularetin 3-sophoroside
Sexangularetin 3-sophoroside is a PDK1 and Akt phosphorylation activator with neuroprotective properties. Sexangularetin 3-sophoroside restores phosphorylated GSK-3β protein levels. Sexangularetin 3-sophoroside acts as a ROS inhibitor and regulates mRNA expression of superoxide dismutase 1 and catalase. Sexangularetin 3-sophoroside can be used for the research of Parkinson’s disease.
For research use only. We do not sell to patients.
- CAS No.: 114882-17-6
- Formula: C28H32O17
- Molecular Weight:640.54
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
GSK-3β |
Akt |
In Vitro
Sexangularetin 3-sophoroside (compound 5) (5-80 μM; 24 h) protects PC12 cells from 6-OHDA-induced injury, increasing cell viability up to 110.67% at 80 μM and restoring normal cell morphology at 5 μM, with minimal effects on baseline cell viability at concentrations ≤ 20 μM[1].
Sexangularetin 3-sophoroside (5-10 μM; preincubated before 24 h 6-OHDA exposure) reduces excessive ROS generation in 6-OHDA-treated PC12 cells at 5 and 10 μM[1].
Sexangularetin 3-sophoroside (5-10 μM; preincubated before 24 h 6-OHDA exposure) upregulates mRNA expression levels of SOD1 and catalase in 6-OHDA-treated PC12 cells at 5 and 10 μM[1].
Sexangularetin 3-sophoroside (5-10 μM; 30 min preincubation + 24 h) activates the PI3K/Akt/GSK-3β signaling pathway by increasing phosphorylated PDK1, Akt, and GSK-3β levels in 6-OHDA-treated PC12 cells at 5 and 10 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:6-OHDA-treated PC12 cells
-
Concentration:0, 5, 10 μM
-
Incubation Time:preincubated before 24 h 6-OHDA exposure
-
Result:Increased relative superoxide dismutase 1 (SOD1) mRNA levels to ~0.73 and ~0.75 at 5 and 10 μM respectively (from ~0.53 after 6-OHDA treatment).
Increased relative catalase (CAT) mRNA levels to ~0.70 and ~0.75 at 5 and 10 μM respectively (from ~0.51 after 6-OHDA treatment).
-
Cell Line:6-OHDA-treated PC12 cells
-
Concentration:0, 5, 10 μM
-
Incubation Time:30 min preincubation + 24 h 6-OHDA co-incubation
-
Result:Significantly alleviated the declines in phosphorylated PDK1, Akt, and GSK-3β protein levels caused by 6-OHDA treatment, increasing the levels of all three phosphorylated proteins.
Chemical Information
-
CAS No. 114882-17-6
-
Molecular Weight 640.54
-
Formula C28H32O17
-
SMILES
O=C(C(O[C@H]1[C@@H]([C@H]([C@@H]([C@H](O1)CO)O)O)O[C@@H]2O[C@@H]([C@H]([C@@H]([C@H]2O)O)O)CO)=C(C3=CC=C(C=C3)O)OC4=C(OC)C(O)=C5)C4=C5O
-
Structure Classification
-
Initial Source
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Sexangularetin 3-sophoroside Related Classifications
HY-N17990 Related Classifications
Powered by Bioz