2. PI3K/Akt/mTOR Stem Cell/Wnt Metabolic Enzyme/Protease Immunology/Inflammation NF-κB
  3. PDK-1 Akt GSK-3 Reactive Oxygen Species (ROS)
  4. Sexangularetin 3-sophoroside

Sexangularetin 3-sophoroside is a PDK1 and Akt phosphorylation activator with neuroprotective properties. Sexangularetin 3-sophoroside restores phosphorylated GSK-3β protein levels. Sexangularetin 3-sophoroside acts as a ROS inhibitor and regulates mRNA expression of superoxide dismutase 1 and catalase. Sexangularetin 3-sophoroside can be used for the research of Parkinson’s disease.

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Sexangularetin 3-sophoroside

Sexangularetin 3-sophoroside Chemical Structure

CAS No. : 114882-17-6

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Sexangularetin 3-sophoroside Related Antibodies

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Description

Sexangularetin 3-sophoroside is a PDK1 and Akt phosphorylation activator with neuroprotective properties. Sexangularetin 3-sophoroside restores phosphorylated GSK-3β protein levels. Sexangularetin 3-sophoroside acts as a ROS inhibitor and regulates mRNA expression of superoxide dismutase 1 and catalase. Sexangularetin 3-sophoroside can be used for the research of Parkinson’s disease[1].

IC50 & Target[1]

GSK-3β

 

Akt

 

In Vitro

Sexangularetin 3-sophoroside (compound 5) (5-80 μM; 24 h) protects PC12 cells from 6-OHDA-induced injury, increasing cell viability up to 110.67% at 80 μM and restoring normal cell morphology at 5 μM, with minimal effects on baseline cell viability at concentrations ≤ 20 μM[1].
Sexangularetin 3-sophoroside (5-10 μM; preincubated before 24 h 6-OHDA exposure) reduces excessive ROS generation in 6-OHDA-treated PC12 cells at 5 and 10 μM[1].
Sexangularetin 3-sophoroside (5-10 μM; preincubated before 24 h 6-OHDA exposure) upregulates mRNA expression levels of SOD1 and catalase in 6-OHDA-treated PC12 cells at 5 and 10 μM[1].
Sexangularetin 3-sophoroside (5-10 μM; 30 min preincubation + 24 h) activates the PI3K/Akt/GSK-3β signaling pathway by increasing phosphorylated PDK1, Akt, and GSK-3β levels in 6-OHDA-treated PC12 cells at 5 and 10 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Sexangularetin 3-sophoroside Related Antibodies

Real Time qPCR[1]

Cell Line: 6-OHDA-treated PC12 cells
Concentration: 0, 5, 10 μM
Incubation Time: preincubated before 24 h 6-OHDA exposure
Result: Increased relative superoxide dismutase 1 (SOD1) mRNA levels to ~0.73 and ~0.75 at 5 and 10 μM respectively (from ~0.53 after 6-OHDA treatment).
Increased relative catalase (CAT) mRNA levels to ~0.70 and ~0.75 at 5 and 10 μM respectively (from ~0.51 after 6-OHDA treatment).

Western Blot Analysis[1]

Cell Line: 6-OHDA-treated PC12 cells
Concentration: 0, 5, 10 μM
Incubation Time: 30 min preincubation + 24 h 6-OHDA co-incubation
Result: Significantly alleviated the declines in phosphorylated PDK1, Akt, and GSK-3β protein levels caused by 6-OHDA treatment, increasing the levels of all three phosphorylated proteins.
Molecular Weight

640.54

Formula

C28H32O17
CAS No.
SMILES

O=C(C(O[C@H]1[C@@H]([C@H]([C@@H]([C@H](O1)CO)O)O)O[C@@H]2O[C@@H]([C@H]([C@@H]([C@H]2O)O)O)CO)=C(C3=CC=C(C=C3)O)OC4=C(OC)C(O)=C5)C4=C5O
Structure Classification
Initial Source
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Sexangularetin 3-sophoroside Related Classifications

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Keywords:

Sexangularetin 3-sophoroside114882-17-6PDK-1AktGSK-3Reactive Oxygen Species (ROS)3-Phosphoinositide-dependent protein kinase 1PKBProtein kinase BGlycogen synthase kinase-3Glycogen synthase kinase 3reactive oxygen speciesPDK1catalasePI3K/Akt/GSK-3β signaling pathway6-OHDAsuperoxide dismutase 1PC12 cellsGSK-3βparkinson's diseaseInhibitorinhibitorinhibit

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