SIRT5 inhibitor 7

Cat. No.: HY-149426: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

SIRT5 inhibitor 7 (compound 58) is a substrate-competitive and selective SIRT5 inhibitor with anti-inflammatory activity. SIRT5 inhibitor 7 has renal protective effects and regulates protein succinylation and the release of pro-inflammatory cytokines. SIRT5 inhibitor 7 has in vivo activity in AKI mouse models of lipopolysaccharide (LPS) and cecal ligation/perforation (CLP)-induced sepsis-related acute kidney injury.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

SIRT5 inhibitor 7 화학구조

CAS No. : 2951090-00-7

사이즈	재고	수량
1 mg	견적 받기 2 - 3 weeks 1-2 weeks 3 - 4 weeks 2-3 weeks	Estimated Time of Arrival: December 31
5 mg	견적 받기 2 - 3 weeks 1-2 weeks 3 - 4 weeks 2-3 weeks	Estimated Time of Arrival: December 31
10 mg	견적 받기 2 - 3 weeks 1-2 weeks 3 - 4 weeks 2-3 weeks	Estimated Time of Arrival: December 31
25 mg	견적 받기 2 - 3 weeks 1-2 weeks 3 - 4 weeks 2-3 weeks	Estimated Time of Arrival: December 31
50 mg	견적 받기
100 mg	견적 받기

Synthetic products have potential research and development risk.

or 대량구매 문의

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 Customer Validation

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Sirtuin SIRT1 SIRT2 SIRT3 SIRT6 SIRT5 SIRT7 SIRT4

Biological Activity
순도&문서
References
고객리뷰

제품 설명

IC₅₀ & Target

IC50: 310 nM (SIRT5)^[1]

분자량

582.12

화학식

C₂₈H₃₂ClN₇O₃S

CAS No.

2951090-00-7

Appearance

Solid

Color

White to light yellow

SMILES

S=C(NCCCNC1=NC(NC2=C(Cl)C=CC=C2)=NC=C1C(N3C[C@@H](C4=CC=CC=C4)CC3)=O)NCCC(O)=O

선적

Room temperature in continental US; may vary elsewhere.

보관

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

순도&문서

Purity: 99.63%

Select Batch:

Data Sheet (267 KB) SDS (252 KB)

COA (248 KB) HNMR (116 KB) LCMS (165 KB)

Handling Instructions (2659 KB)

References

[1]. Mou L, et al. Structure-Activity Relationship Studies of 2,4,5-Trisubstituted Pyrimidine Derivatives Leading to the Identification of a Novel and Potent Sirtuin 5 Inhibitor against Sepsis-Associated Acute Kidney Injury. J Med Chem. 2023 Aug 24;66(16):11517-11535.. [Content Brief]