2. Metabolic Enzyme/Protease
  3. Phospholipase
  4. SMS1-IN-1

SMS1-IN-1, compound SAPA 1j, is a novel and the most potent sphingomyelin synthase 1 (SMS1) inhibitor with an IC50 value of 2.1 μM. SMS1-IN-1 has the potential for the treatment of atherosclerosis.

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SMS1-IN-1

SMS1-IN-1 화학구조

CAS No. : 1807943-38-9

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무료 샘플 (0.1 - 0.2 mg)   지금 신청하기  
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Solution
10 mM * 1 mL in DMSO 해외재고보유
Solid
5 mg 해외재고보유
10 mg 해외재고보유
25 mg 해외재고보유
50 mg 해외재고보유
100 mg 해외재고보유
200 mg   견적 받기  
500 mg   견적 받기  

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SMS1-IN-1 Related Antibodies

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Phospholipase A PLD Phospholipase C

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  • 순도&문서

  • References

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제품 설명

SMS1-IN-1, compound SAPA 1j, is a novel and the most potent sphingomyelin synthase 1 (SMS1) inhibitor with an IC50 value of 2.1 μM. SMS1-IN-1 has the potential for the treatment of atherosclerosis[1].

IC50 & Target

IC50: 2.1 μM (SMS1)[1]
Cellular Effect
Cell Line Type Value Description References
HeLa IC50
2.1 μM
Compound: 1j
Inhibition of sphingomyelin synthase-1 (unknown origin) expressed in HeLa cells using C6-NBD-Cer and DMPC as substrate after 2 hrs by fluorescent HPLC-based analysis
Inhibition of sphingomyelin synthase-1 (unknown origin) expressed in HeLa cells using C6-NBD-Cer and DMPC as substrate after 2 hrs by fluorescent HPLC-based analysis
[PMID: 26314925]
In Vitro

SMS1-IN-1 (2.5, 10 and 50 μM) has a dose-dependent inhibitory effect against SMS1, and is against SMS1 with an IC50 value of 2.1 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SMS1-IN-1 Related Antibodies
분자량

503.41

화학식

C23H23BrN2O4S
CAS No.
Appearance

Solid

Color

Off-white to brown

SMILES

O=C(NCC1=CC=C(Br)C=C1)COC2=CC=C(S(=O)(NCCC3=CC=CC=C3)=O)C=C2
선적

Room temperature in continental US; may vary elsewhere.
보관

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

용액&용해도
In Vitro: 

DMSO : 250 mg/mL (496.61 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9865 mL 9.9323 mL 19.8645 mL
5 mM 0.3973 mL 1.9865 mL 3.9729 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • 농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
순도&문서
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9865 mL 9.9323 mL 19.8645 mL 49.6613 mL
5 mM 0.3973 mL 1.9865 mL 3.9729 mL 9.9323 mL
10 mM 0.1986 mL 0.9932 mL 1.9865 mL 4.9661 mL
15 mM 0.1324 mL 0.6622 mL 1.3243 mL 3.3108 mL
20 mM 0.0993 mL 0.4966 mL 0.9932 mL 2.4831 mL
25 mM 0.0795 mL 0.3973 mL 0.7946 mL 1.9865 mL
30 mM 0.0662 mL 0.3311 mL 0.6622 mL 1.6554 mL
40 mM 0.0497 mL 0.2483 mL 0.4966 mL 1.2415 mL
50 mM 0.0397 mL 0.1986 mL 0.3973 mL 0.9932 mL
60 mM 0.0331 mL 0.1655 mL 0.3311 mL 0.8277 mL
80 mM 0.0248 mL 0.1242 mL 0.2483 mL 0.6208 mL
100 mM 0.0199 mL 0.0993 mL 0.1986 mL 0.4966 mL
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SMS1-IN-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SMS1-IN-11807943-38-9PhospholipaseatherosclerosisSM biosyntheticInhibitorinhibitorinhibit

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Inquiry Information

상품명:
SMS1-IN-1
Cat. No.:
HY-135642
수량:
MCE Japan Authorized Agent:

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