Sodium chloride, meets analytical specification of Ph. Eur. BP USP, ≤0.00002% Al  (Synonyms: Halite, meets analytical specification of Ph. Eur. BP USP)

Sodium chloride, meets analytical specification of Ph. Eur. BP USP, ≤0.00002% Al, an inorganic salt is an orally active salt. Sodium chloride, meets analytical specification of Ph. Eur. BP USP, ≤0.00002% Al, an inorganic salt induces the expression of ATP1A1. Sodium chloride, meets analytical specification of Ph. Eur. BP USP, ≤0.00002% Al, an inorganic salt induces the pro-inflammatory cytokines IL-2, TNFα, IL-9 and several chemokines. Sodium chloride, meets analytical specification of Ph. Eur. BP USP, ≤0.00002% Al, an inorganic salt enhances the anti-tumor activities of Digoxin (HY-B1049) against small cell lung cancer. Sodium chloride, meets analytical specification of Ph. Eur. BP USP, ≤0.00002% Al, an inorganic salt drives autoimmune disease by the induction of pathogenic Th17 cells^[1][2].

Sodium chloride (10-70 mM; 72 h) enhances the anti-tumor activity of Digoxin (HY-B1049) in SCLC cell lines^[1].
Sodium chloride (40 mM) specifically promote the generation of a highly pathogenic Th17 cell type^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Sodium chloride (3%; p.o. and i.v.; given by drinking water for 6 h before treatment and i.v. with 200 μL 3% NaCl) enhances the anti-tumor activity of Digoxin in mouse model of SCLC^[1].
Sodium chloride (1%-4%; p.o.; chow containing 4% NaCl and tap water containing 1% NaCl) induces Th17 cells and exacerbates experimental autoimmune encephalomyelitis in mice^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

58.44

ClNa

7647-14-5

Solid

White to off-white

[Na]Cl

Room temperature in continental US; may vary elsewhere.

Store at room temperature, keep dry and cool

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

• [1]. Deng K, et al. Sodium chloride (NaCl) potentiates digoxin-induced anti-tumor activity in small cell lung cancer. Cancer Biol Ther. 2019;20(1):52-64.  [Content Brief]

  [2]. Kleinewietfeld M, et al. Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells. Nature. 2013 Apr 25;496(7446):518-22.  [Content Brief]