2. Others Membrane Transporter/Ion Channel Immunology/Inflammation
  3. Biochemical Assay Reagents Na+/K+ ATPase Interleukin Related
  4. Sodium chloride, United States Pharmacopeia (USP) Reference Standard

Sodium chloride, United States Pharmacopeia (USP) Reference Standard  (Synonyms: Halite (Pharmaceutical primary standard, USP))

製品番号: HY-Y0344H
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Sodium chloride, United States Pharmacopeia (USP) Reference Standard is an orally active salt. Sodium chloride, United States Pharmacopeia (USP) Reference Standard induces the expression of ATP1A1. Sodium chloride, for cell culture induces the pro-inflammatory cytokines IL-2, TNFα, IL-9 and several chemokines. Sodium chloride, United States Pharmacopeia (USP) Reference Standard enhances the anti-tumor activities of Digoxin (HY-B1049) against small cell lung cancer. Sodium chloride, United States Pharmacopeia (USP) Reference Standard drives autoimmune disease by the induction of pathogenic Th17 cells.

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Sodium chloride, United States Pharmacopeia (USP) Reference Standard

Sodium chloride, United States Pharmacopeia (USP) Reference Standard 構造式

CAS 番号 : 7647-14-5

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100 mg $100 お問い合わせ 2 - 3 weeks 1 - 2 Weeks 3 - 4 weeks 2 - 3 weeks
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Based on 3 publication(s) in Google Scholar

Other Forms of Sodium chloride, United States Pharmacopeia (USP) Reference Standard:

Sodium chloride, United States Pharmacopeia (USP) Reference Standard 関連抗体

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Interleukin Related アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

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製品説明

Sodium chloride, United States Pharmacopeia (USP) Reference Standard is an orally active salt. Sodium chloride, United States Pharmacopeia (USP) Reference Standard induces the expression of ATP1A1. Sodium chloride, for cell culture induces the pro-inflammatory cytokines IL-2, TNFα, IL-9 and several chemokines. Sodium chloride, United States Pharmacopeia (USP) Reference Standard enhances the anti-tumor activities of Digoxin (HY-B1049) against small cell lung cancer. Sodium chloride, United States Pharmacopeia (USP) Reference Standard drives autoimmune disease by the induction of pathogenic Th17 cells[1][2].

IC50 & Target[1][2]

IL-2

 

IL-9

 

体外実験

Sodium chloride (10-70 mM; 72 h) enhances the anti-tumor activity of Digoxin (HY-B1049) in SCLC cell lines[1].
Sodium chloride (40 mM) specifically promote the generation of a highly pathogenic Th17 cell type[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Sodium chloride, United States Pharmacopeia (USP) Reference Standard 関連抗体
体内実験

Sodium chloride (3%; p.o. and i.v.; given by drinking water for 6 h before treatment and i.v. with 200 μL 3% NaCl) enhances the anti-tumor activity of Digoxin in mouse model of SCLC[1].
Sodium chloride (1%-4%; p.o.; chow containing 4% NaCl and tap water containing 1% NaCl) induces Th17 cells and exacerbates experimental autoimmune encephalomyelitis in mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Small cell lung cancer mice[1]
Dosage: 3%
Administration: p.o. and i.v.; given by drinking water for 6 h before treatment and i.v. with 200 μL 3% NaCl
Result: Did not induce significant tumor growth inhibition.
Reduced tumor volume when combination with Digoxin.
分子量

58.44

分子式

ClNa
CAS 番号
SMILES

[Na]Cl
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
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Sodium chloride, United States Pharmacopeia (USP) Reference Standard Related Classifications

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Keywords:

Sodium chloride, United States Pharmacopeia (USP) Reference Standard7647-14-5Halite (Pharmaceutical primary standard, USP)Biochemical Assay ReagentsNa+/K+ ATPaseInterleukin RelatedSodium potassium pumpILInorganic saltSodium chlorideInhibitorinhibitorinhibit

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