2. Stem Cell/Wnt
  3. Large Tumor Suppressor (LATS) YAP
  4. TDI-011536

TDI-011536 is a potent Lats kinase inhibitor, interrupts Hippo-Yap signaling and initiates the proliferation of lesioned heartmuscle cells. TDI-011536 can be used in studies of organ conservation and regeneration.

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CAS 番号 : 2687970-96-1

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>無料サンプル (0.1 - 0.2 mg)   今すぐ申し込む  
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 71 在庫あり
Solution
10 mM * 1 mL in DMSO USD 71 在庫あり
Solid
5 mg $65 在庫あり
10 mg $100 在庫あり
25 mg $210 在庫あり
50 mg $340 在庫あり
100 mg $550 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

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カスタマーレビュー

Based on 3 publication(s) in Google Scholar

TDI-011536 関連抗体

Top Publications Citing Use of Products

    TDI-011536 purchased from MedChemExpress. Usage Cited in: bioRxiv. 2025 Nov 18.

    Mitochondrial morphology visualized by MitoTracker staining following TMAO treatment, with or without the Hippo pathway inhibitor TDI-011536 (4 μM, 24 h). Scale bar, 20 μm.

    TDI-011536 purchased from MedChemExpress. Usage Cited in: bioRxiv. 2025 Nov 18.

    Western blot of mitochondrial dynamics proteins (Fis1, p-Drp1/Drp1, Drp1, Mfn1, Mfn2) following TMAO and TDI-011536 (4 μM, 24 h) treatment.

    TDI-011536 purchased from MedChemExpress. Usage Cited in: bioRxiv. 2025 Nov 18.

    TM3 cells were treated with TMAO, with or without TDI-011536 (4 μM, 24 h) treatment, and ATP levels were measured.

    TDI-011536 purchased from MedChemExpress. Usage Cited in: bioRxiv. 2025 Nov 18.

    Mitochondrial membrane potential via JC-10 assay. Scale bar, 10 μm. Relative ROS generation in TM3 cells following treatment with TMAO, with or without TDI-011536 (4 μM, 24 h).

    TDI-011536 purchased from MedChemExpress. Usage Cited in: bioRxiv. 2025 Nov 18.

    Cyp11a1 and StAR expression in TM3 cells following TMAO treatment, with or without TDI-011536 (4 μM, 24 h).

    YAP アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    YAP/TAZ YAP/TAZ-TEAD TEAD YAP1

    • 生物活性

    • 純度とドキュメンテーション

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    製品説明

    TDI-011536 is a potent Lats kinase inhibitor, interrupts Hippo-Yap signaling and initiates the proliferation of lesioned heartmuscle cells. TDI-011536 can be used in studies of organ conservation and regeneration[1].

    IC50 & Target

    Lats kinase[1].
    体外実験

    TDI-011536 (3 μM; 24 h) reduces Yap phosphorylation and (3 μM; 5 days) induces proliferation of Müller glia in human retinal organoids[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    TDI-011536 関連抗体

    Cell Proliferation Assay[1]

    Cell Line: human retinal organoids
    Concentration: 3 µM
    Incubation Time: 24 h, 5 days
    Result: Supressed Yap phosphorylation and promoted Müller glia proliferation.
    体内実験

    TDI-011536 (200 mg/kg; i.p.; once) provides over 4 h of Lats inhibition in the liver, heart, and skin and reduces the amount of pYap for at least 4 h after injection in all three organs[1].
    TDI-011536 (100 mg/kg; i.p.; once daily for 2 or 3 days) shows proliferative effect on cardiomyocytes[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Living mice (immunoblot analysis of the heart, liver, and skin immediately after injection)[1].
    Dosage: 200 mg/kg
    Administration: Intraperitoneal injections; once.
    Result: Reduced the amount of pYap for at least 4 h after injection in all three organs and the levels returned to control values within a day.
    Animal Model: Male 8-week-old mice (cryolesion model)[1].
    Dosage: 100 mg/kg
    Administration: Intraperitoneal injections; once daily for 2 or 3 days.
    Result: Promoted cardiomyocytes proliferation.
    分子量

    364.42

    分子式

    C19H16N4O2S
    CAS 番号
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    O=C(C1=CNC2=NC=CC=C12)/N=C(SC=C3CO)/N3CC4=CC=CC=C4
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    溶剤 & 溶解度
    体外: 

    DMSO : 125 mg/mL (343.01 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.7441 mL 13.7204 mL 27.4409 mL
    5 mM 0.5488 mL 2.7441 mL 5.4882 mL
    10 mM 0.2744 mL 1.3720 mL 2.7441 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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    一般には略語で表示されます：C1V1 = C2V2

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    体内:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.08 mg/mL (5.71 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% Corn Oil

      Solubility: ≥ 2.08 mg/mL (5.71 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

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    Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    純度とドキュメンテーション

    純度: 99.91%

    COA (255 KB) HNMR (227 KB) RP-HPLC (202 KB)

    取扱説明書 (2659 KB)
    参考文献

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 2.7441 mL 13.7204 mL 27.4409 mL 68.6022 mL
    5 mM 0.5488 mL 2.7441 mL 5.4882 mL 13.7204 mL
    10 mM 0.2744 mL 1.3720 mL 2.7441 mL 6.8602 mL
    15 mM 0.1829 mL 0.9147 mL 1.8294 mL 4.5735 mL
    20 mM 0.1372 mL 0.6860 mL 1.3720 mL 3.4301 mL
    25 mM 0.1098 mL 0.5488 mL 1.0976 mL 2.7441 mL
    30 mM 0.0915 mL 0.4573 mL 0.9147 mL 2.2867 mL
    40 mM 0.0686 mL 0.3430 mL 0.6860 mL 1.7151 mL
    50 mM 0.0549 mL 0.2744 mL 0.5488 mL 1.3720 mL
    60 mM 0.0457 mL 0.2287 mL 0.4573 mL 1.1434 mL
    80 mM 0.0343 mL 0.1715 mL 0.3430 mL 0.8575 mL
    100 mM 0.0274 mL 0.1372 mL 0.2744 mL 0.6860 mL
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    TDI-011536 Related Classifications

    • Molarity Calculator

    • Dilution Calculator

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    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    TDI-0115362687970-96-1TDI011536TDI 011536Large Tumor Suppressor (LATS)YAPLarge Tumor SuppressorYes-associated proteinorgans regenerateHippocardiomyocytesMüller gliaretinal organoidTRULIInhibitorinhibitorinhibit

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    製品名:
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    製品番号:
    HY-150042
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