TDI-011536

Name: TDI-011536
Brand: MedChemExpress
SKU: HY-150042
Rating: 5.0 (3 reviews)

Cat. No.: HY-150042 Purity: 99.87%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

TDI-011536 is a potent Lats kinase inhibitor, interrupts Hippo-Yap signaling and initiates the proliferation of lesioned heartmuscle cells. TDI-011536 can be used in studies of organ conservation and regeneration.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No. : 2687970-96-1

사이즈	재고	수량

무료 샘플 (0.1 - 0.2 mg)	지금 신청하기
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	해외재고보유	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	해외재고보유	Estimated Time of Arrival: December 31
Solid
5 mg	해외재고보유	Estimated Time of Arrival: December 31
10 mg	해외재고보유	Estimated Time of Arrival: December 31
25 mg	해외재고보유	Estimated Time of Arrival: December 31
50 mg	해외재고보유	Estimated Time of Arrival: December 31
100 mg	해외재고보유	Estimated Time of Arrival: December 31
200 mg	견적 받기
500 mg	견적 받기

or 대량구매 문의

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 3 publication(s) in Google Scholar

3 Publications Citing Use of MCE TDI-011536

Cell Imaging/Staining

Bio/Physico-chemical Assay

: TDI-011536 purchased from MedChemExpress. Usage Cited in: bioRxiv. 2025 Nov 18.; Mitochondrial morphology visualized by MitoTracker staining following TMAO treatment, with or without the Hippo pathway inhibitor TDI-011536 (4 μM, 24 h). Scale bar, 20 μm.

: TDI-011536 purchased from MedChemExpress. Usage Cited in: bioRxiv. 2025 Nov 18.; Western blot of mitochondrial dynamics proteins (Fis1, p-Drp1/Drp1, Drp1, Mfn1, Mfn2) following TMAO and TDI-011536 (4 μM, 24 h) treatment.

: TDI-011536 purchased from MedChemExpress. Usage Cited in: bioRxiv. 2025 Nov 18.; TM3 cells were treated with TMAO, with or without TDI-011536 (4 μM, 24 h) treatment, and ATP levels were measured.

: TDI-011536 purchased from MedChemExpress. Usage Cited in: bioRxiv. 2025 Nov 18.; Mitochondrial membrane potential via JC-10 assay. Scale bar, 10 μm. Relative ROS generation in TM3 cells following treatment with TMAO, with or without TDI-011536 (4 μM, 24 h).

: TDI-011536 purchased from MedChemExpress. Usage Cited in: bioRxiv. 2025 Nov 18.; Cyp11a1 and StAR expression in TM3 cells following TMAO treatment, with or without TDI-011536 (4 μM, 24 h).

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Biological Activity
순도&문서
References
고객리뷰

제품 설명

IC₅₀ & Target

Lats kinase^[1].

In Vitro

TDI-011536 (3 μM; 24 h) reduces Yap phosphorylation and (3 μM; 5 days) induces proliferation of Müller glia in human retinal organoids^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:	human retinal organoids
Concentration:	3 µM
Incubation Time:	24 h, 5 days
Result:	Supressed Yap phosphorylation and promoted Müller glia proliferation.

In Vivo

TDI-011536 (200 mg/kg; i.p.; once) provides over 4 h of Lats inhibition in the liver, heart, and skin and reduces the amount of pYap for at least 4 h after injection in all three organs^[1].
TDI-011536 (100 mg/kg; i.p.; once daily for 2 or 3 days) shows proliferative effect on cardiomyocytes^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Living mice (immunoblot analysis of the heart, liver, and skin immediately after injection)^[1].
Dosage:	200 mg/kg
Administration:	Intraperitoneal injections; once.
Result:	Reduced the amount of pYap for at least 4 h after injection in all three organs and the levels returned to control values within a day.

Animal Model:	Male 8-week-old mice (cryolesion model)^[1].
Dosage:	100 mg/kg
Administration:	Intraperitoneal injections; once daily for 2 or 3 days.
Result:	Promoted cardiomyocytes proliferation.

분자량

364.42

화학식

C₁₉H₁₆N₄O₂S

CAS No.

2687970-96-1

Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CNC2=NC=CC=C12)/N=C(SC=C3CO)/N3CC4=CC=CC=C4

선적

Room temperature in continental US; may vary elsewhere.

보관

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

용액&용해도

In Vitro:

DMSO : 125 mg/mL (343.01 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.7441 mL	13.7204 mL	27.4409 mL
5 mM	0.5488 mL	2.7441 mL	5.4882 mL
10 mM	0.2744 mL	1.3720 mL	2.7441 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (5.71 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.08 mg/mL (5.71 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

순도&문서

Purity: 99.91%

Select Batch:

Data Sheet (279 KB) SDS (394 KB)

COA (255 KB) HNMR (227 KB) RP-HPLC (202 KB)

Handling Instructions (2659 KB)

References

[1]. Kastan NR, et al. Development of an improved inhibitor of Lats kinases to promote regeneration of mammalian organs. Proc Natl Acad Sci U S A. 2022 Jul 12;119(28):e2206113119. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.7441 mL	13.7204 mL	27.4409 mL	68.6022 mL
	5 mM	0.5488 mL	2.7441 mL	5.4882 mL	13.7204 mL
	10 mM	0.2744 mL	1.3720 mL	2.7441 mL	6.8602 mL
	15 mM	0.1829 mL	0.9147 mL	1.8294 mL	4.5735 mL
	20 mM	0.1372 mL	0.6860 mL	1.3720 mL	3.4301 mL
	25 mM	0.1098 mL	0.5488 mL	1.0976 mL	2.7441 mL
	30 mM	0.0915 mL	0.4573 mL	0.9147 mL	2.2867 mL
	40 mM	0.0686 mL	0.3430 mL	0.6860 mL	1.7151 mL
	50 mM	0.0549 mL	0.2744 mL	0.5488 mL	1.3720 mL
	60 mM	0.0457 mL	0.2287 mL	0.4573 mL	1.1434 mL
	80 mM	0.0343 mL	0.1715 mL	0.3430 mL	0.8575 mL
	100 mM	0.0274 mL	0.1372 mL	0.2744 mL	0.6860 mL

TDI-011536 Related Classifications

Cardiovascular Disease Others

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TDI-0115362687970-96-1TDI011536TDI 011536Large Tumor Suppressor (LATS)YAPLarge Tumor SuppressorYes-associated proteinorgans regenerateHippocardiomyocytesMüller gliaretinal organoidTRULIInhibitorinhibitorinhibit

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TDI-011536

고객리뷰

TDI-011536 Related Antibodies

3 Publications Citing Use of MCE TDI-011536

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All YAP Isoform Specific Products:

Biological Activity

순도&문서

References

고객리뷰

TDI-011536 Related Antibodies

몰농도 계산기

농도 희석 계산기

Complete Stock Solution Preparation Table

TDI-011536 Related Classifications

Keywords:

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고객리뷰

Request for HNMR Report

SAFETY DATA SHEET (SDS)

Request for HNMR Report