2. Metabolic Enzyme/Protease GPCR/G Protein
  3. Endogenous Metabolite P2Y Receptor
  4. UDP-Galactose

UDP-Galactose is a monosaccharide and a key glycosyl donor molecule in cells that participates in nucleotide sugar metabolism. UDP-Galactose is the natural agonist of the P2Y14 receptor coupled to Gi proteins in the immune system (IC50 = 0.67 μM, hP2Y14). UDP-Galactose can be used to study cell signal transduction and substance metabolism.

It is advisable to consider the salt form (UDP-Galactose disodium) that retains the same biological activity.

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UDP-Galactose

UDP-Galactose Estructura química

No. CAS : 2956-16-3

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UDP-Galactose Related Antibodies

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Descripciòn

UDP-Galactose is a monosaccharide and a key glycosyl donor molecule in cells that participates in nucleotide sugar metabolism. UDP-Galactose is the natural agonist of the P2Y14 receptor coupled to Gi proteins in the immune system (IC50 = 0.67 μM, hP2Y14). UDP-Galactose can be used to study cell signal transduction and substance metabolism[1][2].

IC50 & Target

Human Endogenous Metabolite

 

P2Y14 Receptor

0.67 μM (EC50)

Cellular Effect
Cell Line Type Value Description References
COS-7 EC50
0.67 3
Compound: 2
Agonist activity at human P2Y14 expressed in COS7 cells assessed as stimulation of PLC-mediated [3H]inositol hydrolysis
Agonist activity at human P2Y14 expressed in COS7 cells assessed as stimulation of PLC-mediated [3H]inositol hydrolysis
[PMID: 17407275]
COS-7 EC50
0.67 3
Compound: 2
Agonist activity at human P2Y14 expressed in COS7 cells assessed as stimulation of PLC-mediated [3H]inositol hydrolysis
Agonist activity at human P2Y14 expressed in COS7 cells assessed as stimulation of PLC-mediated [3H]inositol hydrolysis
[PMID: 17407275]
COS-7 EC50
0.67 3
Compound: 7
Agonist activity at human P2Y14 receptor expressed in human COS7 cells
Agonist activity at human P2Y14 receptor expressed in human COS7 cells
[PMID: 19502066]
COS-7 EC50
0.67 3
Compound: 7
Agonist activity at human P2Y14 receptor expressed in human COS7 cells
Agonist activity at human P2Y14 receptor expressed in human COS7 cells
[PMID: 19502066]
In Vitro

UDP-Galactose (2 mM) restores UDP-galactose transport in the endoplasmic reticulum of GalT-1/UGT-CHOlec8 cells[2].
UDP-galactose is transported via the endoplasmic reticulum to support GalCer synthesis in GalT-1/UGT-CHOlec8 cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

UDP-Galactose Related Antibodies
Peso molecular

566.30

Fòrmula

C15H24N2O17P2
No. CAS
SMILES

O=C(C=CN1[C@H]2[C@H](O)[C@H](O)[C@@H](COP(OP(O[C@@H]3[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O3)(O)=O)(O)=O)O2)NC1=O
Structure Classification
Initial Source
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
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UDP-Galactose Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

UDP-Galactose2956-16-3Endogenous MetaboliteP2Y ReceptorUDP-galactose:ceramide galactosyltransferaseGiinositol lipid hydrolysisP2Y?? receptorphospholipase Cendoplasmic reticulum lumenUDP-galactose transporterCOS-7 cellsgalactosylceramidegalactosyldiglyceridesInhibitorinhibitorinhibit

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Nombre del producto:
UDP-Galactose
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HY-150524
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