2. Metabolic Enzyme/Protease GPCR/G Protein
  3. Endogenous Metabolite P2Y Receptor
  4. Uridine 5′-diphosphoglucose disodium

Uridine 5′-diphosphoglucose (disodium salt)  (Synonyms: UDP-D-Glucose (disodium salt); UDP-Glucose (sodium salt))

製品番号: HY-N7032 純度: 99.98%
COA 取扱説明書 Technical Support

Uridine 5’-diphosphoglucose (UDP-glucose) disodium, secreted by cardiomyocytes during ischemia and reperfu, is a potent agonist of the proinflammatory P2Y14 receptor. It acts an important role in the regulation of inflammation and neutrophil polarization in neutrophils. Uridine 5’-diphosphoglucose disodium is also the precursor of glucose-containing oligosaccharides, polysaccharides, glycoproteins, and glycolipids in animal tissues and in some microorganisms. Uridine 5’-diphosphoglucose disodium is promising for research in counteracting myocardial infarction/reperfusion (MIR)-induced inflammation in the heart tissue.

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CAS 番号 : 28053-08-9

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50 mg $32 在庫あり
100 mg $50 在庫あり
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カスタマーレビュー

Based on 8 publication(s) in Google Scholar

Other Forms of Uridine 5′-diphosphoglucose disodium:

Uridine 5′-diphosphoglucose (disodium salt) 関連抗体

Top Publications Citing Use of Products

    Uridine 5′-diphosphoglucose disodium purchased from MedChemExpress. Usage Cited in: BMC Cancer. 2025 Jun 1;25(1):982.  [Abstract]

    Cellular Thermal Shift Assay was performed to detect the interactions between molecules and INF2 protein.The results demonstrated that the thermal stability of INF2 proteins was no significantly changed after treatment with Uridine 5′-diphosphoglucose disodium (10 μM; 24 h) and Alginic acid.

    Uridine 5′-diphosphoglucose disodium purchased from MedChemExpress. Usage Cited in: Clin Immunol. 2024 Jun 29:110300.  [Abstract]

    RNA levels of inflammatory genes in Uridine 5′-diphosphoglucose disodium (UDP-G, 25–100 μM; 24) treated DC2.4 (murine DC cell line) cells. The results showed that UDP-G (25-100 μM) significantly upregulated the expression levels of Cxcl9, Cxcl10, and Il23 in treated mouse DC cells (DC2.4 cell line).

    Endogenous Metabolite アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    Human Endogenous Metabolite Microbial Metabolite

    P2Y Receptor アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    P2Y1 Receptor P2Y2 Receptor P2Y6 Receptor P2Y11 Receptor P2Y12 Receptor P2Y13 Receptor P2Y14 Receptor

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    製品説明

    Uridine 5’-diphosphoglucose (UDP-glucose) disodium, secreted by cardiomyocytes during ischemia and reperfu, is a potent agonist of the proinflammatory P2Y14 receptor. It acts an important role in the regulation of inflammation and neutrophil polarization in neutrophils. Uridine 5’-diphosphoglucose disodium is also the precursor of glucose-containing oligosaccharides, polysaccharides, glycoproteins, and glycolipids in animal tissues and in some microorganisms. Uridine 5’-diphosphoglucose disodium is promising for research in counteracting myocardial infarction/reperfusion (MIR)-induced inflammation in the heart tissue.

    IC50 & Target

    Human Endogenous Metabolite

     

    P2Y14 Receptor

     

    Microbial Metabolite

     

    体外実験

    Uridine 5’-diphosphoglucose (0-100 μM, 24 h) disodium upregulates the expression of P2Y14 receptor, which induces neutrophil apoptos[2].
    Uridine 5’-diphosphoglucose (1 μM, 24 h) disodium and PPTN (HY-110322A) result in suppressed mRNA level of inflammatory factors including CCL3, IL1β,IL12a, TNF-α in neutrophils compared to cells treated with Uridine 5’-diphosphoglucose disodium alone, on the contrary, anti-inflammatory factors including IL10, TGF-β1, YM1 are upregulated upon Uridine 5’-diphosphoglucose disodium and PPTN (HY-110322A) in neutrophils[2].
    Depletion of the pools of uridine 5’-diphosphoglucose (5 or 20 mM, incubation for 3 h) disodium in the liver of the rat was associated with decreased glycosylation of secreted and tissue glycoproteins, influencing the rate of glomerular basement membrane (GBM) synthesis in rats[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Uridine 5′-diphosphoglucose (disodium salt) 関連抗体

    Cell Viability Assay[2].

    Cell Line: Neutrophils
    Concentration: 0-100 μM
    Incubation Time: 24 h
    Result: Decreased cell viability and elevated apoptosis of neutrophils, which was blunted by PPTN (HY-110322A).

    Cell Migration Assay [2].

    Cell Line: Neutrophils
    Concentration: 1 μM
    Incubation Time: 24 h
    Result: Resulted in impaired neutrophil migration, which was inverted by PPTN (HY-110322A).
    分子量

    610.27

    分子式

    C15H22N2Na2O17P2
    CAS 番号
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    O[C@@H]1[C@H](O)[C@@H](COP(OP(O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)O)O)(O[Na])=O)(O[Na])=O)O[C@H]1N3C=CC(NC3=O)=O
    Structure Classification
    Initial Source
    輸送条件

    Shipping with dry ice.
    保管条件

    -80°C, protect from light, stored under nitrogen
    溶剤 & 溶解度
    体外: 

    H2O : ≥ 250 mg/mL (409.65 mM)

    DMSO : 115 mg/mL (188.44 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.6386 mL 8.1931 mL 16.3862 mL
    5 mM 0.3277 mL 1.6386 mL 3.2772 mL
    10 mM 0.1639 mL 0.8193 mL 1.6386 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始）

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    体積 （開始）

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    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 5 mg/mL (8.19 mM); Clear solution

      This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 0.55 mg/mL (0.90 mM); Clear solution

      This protocol yields a clear solution of ≥ 0.55 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (5.5 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

      Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: 100 mg/mL (163.86 mM); Clear solution; Need ultrasonic

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

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    (per animal)

    g

    Dosing volume
    (per animal)

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    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    純度とドキュメンテーション

    純度: 99.98%

    COA (253 KB) HNMR (286 KB) CNMR (286 KB) RP-HPLC (208 KB) MS (70 KB)

    取扱説明書 (2659 KB)
    参考文献

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO / H2O 1 mM 1.6386 mL 8.1931 mL 16.3862 mL 40.9655 mL
    5 mM 0.3277 mL 1.6386 mL 3.2772 mL 8.1931 mL
    10 mM 0.1639 mL 0.8193 mL 1.6386 mL 4.0965 mL
    15 mM 0.1092 mL 0.5462 mL 1.0924 mL 2.7310 mL
    20 mM 0.0819 mL 0.4097 mL 0.8193 mL 2.0483 mL
    25 mM 0.0655 mL 0.3277 mL 0.6554 mL 1.6386 mL
    30 mM 0.0546 mL 0.2731 mL 0.5462 mL 1.3655 mL
    40 mM 0.0410 mL 0.2048 mL 0.4097 mL 1.0241 mL
    50 mM 0.0328 mL 0.1639 mL 0.3277 mL 0.8193 mL
    60 mM 0.0273 mL 0.1366 mL 0.2731 mL 0.6828 mL
    80 mM 0.0205 mL 0.1024 mL 0.2048 mL 0.5121 mL
    100 mM 0.0164 mL 0.0819 mL 0.1639 mL 0.4097 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Uridine 5′-diphosphoglucose disodium Related Classifications

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質量   濃度   体積   分子量 *
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    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Uridine 5′-diphosphoglucose disodium28053-08-9UDP-D-Glucose disodiumEndogenous MetaboliteP2Y ReceptorCardiomyocytesP2Y14 agonistInflammationNeutrophil polarizationNeutrophilsAnimal tissuesInhibitorinhibitorinhibit

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    製品名:
    Uridine 5′-diphosphoglucose disodium
    製品番号:
    HY-N7032
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