2. Apoptosis Metabolic Enzyme/Protease
  3. Apoptosis Endogenous Metabolite
  4. Violacein

Violacein  (Synonyms: バイオラセイン)

製品番号: HY-119809 純度: 99.97%
COA 取扱説明書 Technical Support

Violacein, a secondary metabolite produced by several microorganisms, possesses potent anticancer and low side effects. Violacein possesses antioxidant properties. Apoptosis inducer.

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Violacein

Violacein 構造式

CAS 番号 : 548-54-9

容量 価格（税別） 在庫状況 数量
1 mg $354 在庫あり
5 mg $885 在庫あり
10 mg $1416 在庫あり
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100 mg   お問い合わせ  

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Based on 0 publication(s) in Google Scholar

Violacein 関連抗体

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Endogenous Metabolite アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
Human Endogenous Metabolite Microbial Metabolite

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製品説明

Violacein, a secondary metabolite produced by several microorganisms, possesses potent anticancer and low side effects. Violacein possesses antioxidant properties. Apoptosis inducer[1][2].

IC50 & Target

Microbial Metabolite

 

Cellular Effect
Cell Line Type Value Description References
Caco-2 IC50
>1.5 μM
Compound: violacein
Cytotoxicity against Homo sapiens (human) Caco2 cells after 24 to 48 hr by MTT assay
Cytotoxicity against Homo sapiens (human) Caco2 cells after 24 to 48 hr by MTT assay
10.1007/s00044-011-9654-9
DLD-1 IC50
>1.5 μM
Compound: violacein
Cytotoxicity against Homo sapiens (human) DLD1 cells after 24 to 48 hr by MTT assay
Cytotoxicity against Homo sapiens (human) DLD1 cells after 24 to 48 hr by MTT assay
10.1007/s00044-011-9654-9
HCT-116 IC50
>1.5 μM
Compound: violacein
Cytotoxicity against Homo sapiens (human) HCT116 cells after 24 to 48 hr by MTT assay
Cytotoxicity against Homo sapiens (human) HCT116 cells after 24 to 48 hr by MTT assay
10.1007/s00044-011-9654-9
HEp-2 IC50
2.2 μM
Compound: violacein
Cytotoxicity against Homo sapiens (human) Hep2 cells
Cytotoxicity against Homo sapiens (human) Hep2 cells
10.1007/s00044-011-9654-9
HL-60 IC50
0.8 μM
Compound: violacein
Cytotoxicity against Homo sapiens (human) HL60 cells
Cytotoxicity against Homo sapiens (human) HL60 cells
10.1007/s00044-011-9654-9
HT-29 IC50
>1.5 μM
Compound: violacein
Cytotoxicity against Homo sapiens (human) HT-29 cells after 24 to 48 hr by MTT assay
Cytotoxicity against Homo sapiens (human) HT-29 cells after 24 to 48 hr by MTT assay
10.1007/s00044-011-9654-9
K562 IC50
<1 μM
Compound: violacein
Cytotoxicity against Homo sapiens (human) K562 cells
Cytotoxicity against Homo sapiens (human) K562 cells
10.1007/s00044-011-9654-9
KM12 GI50
0.03 μM
Compound: violacein
Cytotoxicity against Homo sapiens (human) KM12 cells
Cytotoxicity against Homo sapiens (human) KM12 cells
10.1007/s00044-011-9654-9
Lymphocyte IC50
10 μM
Compound: violacein
Cytotoxicity against Homo sapiens (human) Lymphocyte
Cytotoxicity against Homo sapiens (human) Lymphocyte
10.1007/s00044-011-9654-9
MOLT-4 GI50
0.03 μM
Compound: violacein
Cytotoxicity against Homo sapiens (human) MOLT4 cells
Cytotoxicity against Homo sapiens (human) MOLT4 cells
10.1007/s00044-011-9654-9
NCI-H460 GI50
0.03 μM
Compound: violacein
Cytotoxicity against Homo sapiens (human) NCI-H460 cells
Cytotoxicity against Homo sapiens (human) NCI-H460 cells
10.1007/s00044-011-9654-9
U-937 IC50
<1 μM
Compound: violacein
Cytotoxicity against Homo sapiens (human) U937 cells
Cytotoxicity against Homo sapiens (human) U937 cells
10.1007/s00044-011-9654-9
V79 IC50
5 μM
Compound: violacein
Cytotoxicity against Cricetulus griseus V79 cells
Cytotoxicity against Cricetulus griseus V79 cells
10.1007/s00044-011-9654-9
Vero IC50
2.2 μM
Compound: violacein
Cytotoxicity against Homo sapiens (human) Vero cells
Cytotoxicity against Homo sapiens (human) Vero cells
10.1007/s00044-011-9654-9
体外実験

Violacein (0.25-3 µM; 24h; HCT116 and HT29 cells) possesses anticancer activity in both 2D and 3D cell models[1].
Violacein decreases RTKs expression and disturbs signaling pathways in CRC cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Violacein 関連抗体

Cell Viability Assay[1].

Cell Line: HCT116 and HT29 (1.8 × 104 cells/well-100 µL) cells.
Concentration: 0.25, 0.5, 1.0, 1.5, 2.0, 2.5, and 3.0 µM.
Incubation Time: 24h.
Result: In the 2D culture model, the violacein treatment reduced the cell viability, since there was a decrease in formazan production in the HT29 and HCT116 cell lines. Moreover, HT29 was more sensitive to violacein, as evidenced by the IC50 value (0.6 μM) compared to HCT116 (1.2 μM).
分子量

343.34

分子式

C20H13N3O3
CAS 番号
Appearance

Solid

Color

Brown to black

SMILES

O=C1/C(C2=CC=CC=C2N1)=C3C=C(C(C4=C5)=CNC4=CC=C5O)NC\3=O
Structure Classification
Initial Source

Chromobacterium violaceum
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 10 mg/mL (29.13 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9126 mL 14.5628 mL 29.1256 mL
5 mM 0.5825 mL 2.9126 mL 5.8251 mL
10 mM 0.2913 mL 1.4563 mL 2.9126 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
純度とドキュメンテーション
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9126 mL 14.5628 mL 29.1256 mL 72.8141 mL
5 mM 0.5825 mL 2.9126 mL 5.8251 mL 14.5628 mL
10 mM 0.2913 mL 1.4563 mL 2.9126 mL 7.2814 mL
15 mM 0.1942 mL 0.9709 mL 1.9417 mL 4.8543 mL
20 mM 0.1456 mL 0.7281 mL 1.4563 mL 3.6407 mL
25 mM 0.1165 mL 0.5825 mL 1.1650 mL 2.9126 mL
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Violacein Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Violacein548-54-9ApoptosisEndogenous MetaboliteAnticancerMicroorganisms Secondary Metaboliteantioxidantapoptosiscolon cancer,Inhibitorinhibitorinhibit

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製品名:
Violacein
製品番号:
HY-119809
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