548-54-9
548-54-9
Chemical Structure
Violacein
- CAS No.: 548-54-9
- Formula:C20H13N3O3
- Molecular Weight:343.34
IUPAC Name: (E)-3-(5-(5-hydroxy-1H-indol-3-yl)-2-oxo-1,2-dihydro-3H-pyrrol-3-ylidene)indolin-2-one
InChIKey: XAPNKXIRQFHCHN-QGOAFFKASA-N
SMILES: O=C1/C(C2=CC=CC=C2N1)=C3C=C(C(C4=C5)=CNC4=CC=C5O)NC\3=O
Biological Activity: Violacein, a secondary metabolite produced by several microorganisms, possesses potent anticancer and low side effects. Violacein possesses antioxidant properties. Apoptosis inducer[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Violacein | 99.97% | Violacein, a secondary metabolite produced by several microorganisms, possesses potent anticancer and low side effects. Violacein possesses antioxidant properties. Apoptosis inducer. | ||||||||||||||||||||
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Isoindigo | 99.67% | Isoindigo acts as the acceptor unit in donor-acceptor (D-A) conjugated polymers and belongs to the indigo dye family. Isoindigo contains two lactam rings and exhibits strong electron-withdrawing properties. Isoindigo can be used in dyeing and pigment preparation. Isoindigo shows high mobility and excellent environmental stability in field-effect transistors (FETs). Isoindigo possesses the activity to inhibit tumor cell proliferation and has certain anti-tumor activity. | ||||||||||||||||||||
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Bisindolylmaleimide IV | 99.71% | Bisindolylmaleimide IV (Arcyriarubin A) is a potent protein kinase C (PKC) inhibitor, with IC50s ranging from 0.1 to 0.55 μM. Bisindolylmaleimide IV also inhibits PKA (IC50=3.1-11.8μM). Bisindolylmaleimide IV is a potent, selective inhibitor of human cytomegalovirus (HCMV) replication in cell culture with an IC50 of 0.2 μM. | ||||||||||||||||||||
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Deoxyviolacein | Deoxyviolacein is a bacterial metabolite and byproduct in the biosynthesis of the bisindole alkaloid violacein (HY-119809) that has anticancer, antibacterial, and antifungal properties. It inhibits proliferation of hepatocellular carcinoma cells when used at concentrations ranging from 0.1 to 1 μM. Deoxyviolacein (125 μg/mL) has antibacterial activity against Gram-positive bacteria, including S. aureus, B. subtilis, and B. megaterium. It also has antifungal activity against R. solani when used at a concentration of 2 mg/ml. | |||||||||||||||||||||
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A3334 | 99.64% | A3051 is a potent and orally active inhibtor of CXXC5-DVL extracted from patent WO2020079569, has an IC50 of 63.06 nM. A3334 can be used for the research of high fat diet (HFD)-induced and methionine-choline deficient diet (MCD)-induced phenotypes such as obesity, diabetes, and NASH. | ||||||||||||||||||||
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Topo I-IN-1 | Topo I-IN-1 (Compound 14d) is a potent Topo I inhibitor with antitumor activity and DNA intercalative capability. Topo I-IN-1 induces cell apoptosis. | |||||||||||||||||||||
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KY19334 | 99.78% | KY19334 is a CXXC5-DVL inhibitor. KY19334 can activate the Wnt/β-catenin pathway by inhibiting CXXC5-Dvl interaction. KY19334 can inhibit cancer cells proliferation, migration, invasion and transformation by inhibiting CDK1. KY19334 can accelerate wound healing and exert regenerative effects. KY19334 can be used for the researches of cancer, inflammation, metabolic and neurological disease, such as cutaneous squamous cell carcinoma and diabetes. | ||||||||||||||||||||
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ATM ligand-1 | ATM ligand-1 is an ATM ligand that can be used for the synthesis of PROTACs, such as PROTAC ATM degrader-1 (HY-158345). | |||||||||||||||||||||
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Indirubin | 99.37% | Indirubin (Couroupitine B) is a bis-indole alkaloid and has emarkable anticancer activity against chronic myelocytic leukemia. | ||||||||||||||||||||
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(Z)-Indirubin | 99.95% | (Z)-Indirubin is an isomer of Indirubin (HY-N0117). Indirubin is a bis-indole alkaloid and has emarkable anticancer activity against chronic myelocytic leukemia. | ||||||||||||||||||||
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Trigonostemon F | Trigonostemon F is a modified euphorbia diterpenoid, which is found in the roots of Trigonostemon thyrsoideum and the stems of Trigonostemon howii. Trigonostemon F inhibits the proliferation of human tumor cell lines and the growth of specific bacteria in vitro. Trigonostemon F is applicable to cancer-related research. | |||||||||||||||||||||
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References
- [1]. Patricia F de Souza Oliveira, et al. Violacein negatively modulates the colorectal cancer survival and epithelial-mesenchymal transition. J Cell Biochem. 2022 Jul;123(7):1247-1258. [Content Brief]
- [2]. Marlon Konzen, et al. Antioxidant properties of violacein: possible relation on its biological function. Bioorg Med Chem. 2006 Dec 15;14(24):8307-13. [Content Brief]
