1. Epigenetics
    TGF-beta/Smad
    Anti-infection
  2. PKC
    CMV
  3. Bisindolylmaleimide IV

Bisindolylmaleimide IV (Synonyms: Arcyriarubin A)

Cat. No.: HY-108254
Handling Instructions

Bisindolylmaleimide IV (Arcyriarubin A) is a potent protein kinase C (PKC) inhibitor, with IC50s ranging from 0.1 to 0.55 μM. Bisindolylmaleimide IV also inhibits PKA (IC50=3.1-11.8μM). Bisindolylmaleimide IV is a potent, selective inhibitor of human cytomegalovirus (HCMV) replication in cell culture with an IC50 of 0.2 μM.

For research use only. We do not sell to patients.

Bisindolylmaleimide IV Chemical Structure

Bisindolylmaleimide IV Chemical Structure

CAS No. : 119139-23-0

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Description

Bisindolylmaleimide IV (Arcyriarubin A) is a potent protein kinase C (PKC) inhibitor, with IC50s ranging from 0.1 to 0.55 μM. Bisindolylmaleimide IV also inhibits PKA (IC50=3.1-11.8μM)[1]. Bisindolylmaleimide IV is a potent, selective inhibitor of human cytomegalovirus (HCMV) replication in cell culture with an IC50 of 0.2 μM[2].

IC50 & Target[1][2]

PKC

0.1-0.55 μM (IC50)

HCMV

0.2 μM (IC50)

In Vitro

Bisindolylmaleimide IV (Arcyriarubin A) inhibits PKC with an IC50 of 0.1 μM in 1 % DMSO, while the IC50 of 0.55 μM in 10 % DMSO[1].

Molecular Weight

327.34

Formula

C₂₀H₁₃N₃O₂

CAS No.

119139-23-0

SMILES

O=C(C(C1=CNC2=C1C=CC=C2)=C3C4=CNC5=C4C=CC=C5)NC3=O

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Bisindolylmaleimide IVArcyriarubin APKCCMVProtein kinase CCytomegalovirushumancytomegalovirusdiseaseselectiveDMSOdiscriminativeInhibitorinhibitorinhibit

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