2. Cell Cycle/DNA Damage Apoptosis Metabolic Enzyme/Protease Immunology/Inflammation NF-κB
  3. Topoisomerase Apoptosis Reactive Oxygen Species
  4. Topo I-IN-1

Topo I-IN-1 (Compound 14d) is a potent Topo I inhibitor with antitumor activity and DNA intercalative capability. Topo I-IN-1 induces cell apoptosis.

For research use only. We do not sell to patients.

Topo I-IN-1 Chemical Structure

Topo I-IN-1 Chemical Structure

CAS No. : 2763655-68-9

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Topo I-IN-1 Related Antibodies

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Description

Topo I-IN-1 (Compound 14d) is a potent Topo I inhibitor with antitumor activity and DNA intercalative capability. Topo I-IN-1 induces cell apoptosis[1].

IC50 & Target

Topoisomerase I

 

In Vitro

Topo I-IN-1 (Compound 14d) (0-50 µM, 48 h) shows antiproliferative activity against human cancer cells and has low toxicity toward normal rat kidney epithelial cells[1].
Topo I-IN-1 (0-4 µM, 48 h) shows a dose-dependent apoptotic effect, induces ROS generation, and inhibits cell migration[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Topo I-IN-1 Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: A549, HCT116, MCF7, SK-MEL-28, and NRK (normal rat kidney epithelial cells)
Concentration: 0-50 µM
Incubation Time: 48 h
Result: Showed in vitro cytotoxicity with IC50 values of 2.33 ± 1.52, 2.85 ± 0.83, 26.23 ± 2.48, 3.86 ± 0.33, and 29.99 ± 0.95 µM against A549, HCT116, MCF7, SK-MEL-28, and NRK cells, respectively.

Apoptosis Analysis[1]

Cell Line: A549
Concentration: 2, 2.33 and 4 μM
Incubation Time: 48 h
Result: Resulted in the morphological changes typical to apoptosis.
Molecular Weight

408.25

Formula

C20H14BrN3O2
CAS No.
SMILES

O=C1NCC/C(C2=C1NC3=C2C=CC=C3)=C4C(NC5=C/4C=CC(Br)=C5)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Topo I-IN-1 Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Topo I-IN-12763655-68-9TopoisomeraseApoptosisReactive Oxygen SpeciesantitumorA549HCT116MCF7SK-MEL-28Inhibitorinhibitorinhibit

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