2. Immunology/Inflammation
  3. Interleukin Related
  4. Vobarilizumab

Vobarilizumab  (Synonyms: ALX-0061)

製品番号: HY-P99385 純度: 99.9%
COA Technical Support

Vobarilizumab (ALX-0061) is a humanized bispecific anti-IL-6R and anti-human serum albumin (ALB) monoclonal antibody (mAb) (Kd: 0.19 pM). Vobarilizumab consists of an anti-IL-6R domain and an anti-human serum albumin domain. Vobarilizumab can be used in the research of inflammatory autoimmune diseases, such as rheumatoid arthritis.

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CAS 番号 : 1628814-88-9

容量 価格（税別） 在庫状況 数量
1 mg $420 在庫あり
5 mg $1340 在庫あり
10 mg $2280 在庫あり
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Vobarilizumab 関連抗体

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Interleukin Related アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

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製品説明

Vobarilizumab (ALX-0061) is a humanized bispecific anti-IL-6R and anti-human serum albumin (ALB) monoclonal antibody (mAb) (Kd: 0.19 pM). Vobarilizumab consists of an anti-IL-6R domain and an anti-human serum albumin domain. Vobarilizumab can be used in the research of inflammatory autoimmune diseases, such as rheumatoid arthritis[1][2][3].

Isotype

VH-VH'
Species Reactivity

Human
IC50 & Target

IL-6Ra & ALB
体外実験

Vobarilizumab shows a preferential binding affinity for sIL-6R compared with mIL-6R[2].
Vobarilizumab (0-10 nM) blocks the interaction of recombinant hIL-6 to recombinant hsIL-6R[3].
Vobarilizumab (0-100 nM) blocks proliferation of the TF-1 cells[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Vobarilizumab 関連抗体
体内実験

Vobarilizumab (0.4-10 mg/kg, i.v.) inhibits hIL-6-induced inflammation in cynomolgus monkey[3].
Vobarilizumab (0.4-10 mg/kg, i.v.) shows a prolonged exposure through binding to serum albumin in cynomolgus monkeys[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: hIL-6-induced inflammation in cynomolgus monkey[3]
Dosage: 0.4 mg/kg, 2 mg/kg, or 10 mg/kg
Administration: Intravenous injection (i.v.)
Result: Inhibited the acute phase response parameters: plasma levels of C-reactive protein (CRP), fibrinogen and platelets.
Animal Model: Cynomolgus monkeys[3]
Dosage: 0.4 mg/kg, 2 mg/kg, or 10 mg/kg
Administration: Intravenous injection (i.v.)
Result: Pharmacokinetic parameters of Vobarilizumab
dose (mg/kg) T1/2 dominant (day) AUCinf (μg/day/mL) CL (mL/day/kg) Vss (mL/kg)
0.4 (i.v.) 1.73 16.3 24.8 42.8
2 (i.v.) 5.0 193 10.4 53.7
10 (i.v.) 6.61 1136 9 82.7
臨床実験
Gene ID

3570  [NCBI] & 213  [NCBI]

Accession
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

25.69 kDa

CAS 番号
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Vobarilizumab]
輸送条件

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • VH-VH'
Biological Activity
  • Immobilized Human IL-6R Protein (ECD, His Tag) can bind Vobarilizumab. The EC50 for this effect is 2.34 ng/mL.
  • Immobilized Serum Albumin/ALB Protein, Human (HEK293, His-Avi, HY-P78393) can bind Vobarilizumab. The EC50 for this effect is 183.3 ng/mL.
純度とドキュメンテーション
参考文献
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Vobarilizumab Related Classifications

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Vobarilizumab1628814-88-9ALX-0061ALX0061ALX 0061Interleukin RelatedILRheumatoid arthritisRATF-1 cellhIL-6inflammationInhibitorinhibitorinhibit

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製品名:
Vobarilizumab
製品番号:
HY-P99385
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