YAP/TAZ inhibitor-2

Name: YAP/TAZ inhibitor-2
Brand: MedChemExpress
SKU: HY-147322
Rating: 4.5 (1 reviews)

Cat. No.: HY-147322 Pureté: 99.11%: Fiche technique
COA

SDS
Instruction de manipulation
FAQs
Technical Support

YAP/TAZ inhibitor-2 is a potent and orally active TEAD-YAP/TAZ inhibitor with an EC₅₀ value of 3 nM. YAP/TAZ inhibitor-2 shows anti-proliferative activity. YAP/TAZ inhibitor-2 shows antitumor activity.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

YAP/TAZ inhibitor-2 Chemical Structure

CAS No. : 2762617-31-0

Size	Stock	Quantité
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	En stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	En stock	Estimated Time of Arrival: December 31
Solid
5 mg	En stock	Estimated Time of Arrival: December 31
10 mg	En stock	Estimated Time of Arrival: December 31
25 mg	En stock	Estimated Time of Arrival: December 31
50 mg	En stock	Estimated Time of Arrival: December 31
100 mg	En stock	Estimated Time of Arrival: December 31
200 mg	Obtenir un devis
500 mg	Obtenir un devis

or Bulk Inquiry

* Veuillez sélectionner la quantité avant d'ajouter des articles.

This product is a controlled substance and not for sale in your territory.

Avis client

Based on 1 publication(s) in Google Scholar

1 Publications Citing Use of MCE YAP/TAZ inhibitor-2

•iScience. 2025 Aug 21;28(9):113419.

Recommandations en vedette

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Voir tous les produits spécifiques à Isoform YAP:

Voir toutes les isoformes

YAP/TAZ YAP/TAZ-TEAD TEAD YAP1

Activité biologique
Pureté et documentation
Références
Avis client

Description

IC₅₀ & Target

YAP/TAZ-TEAD

In Vitro

YAP/TAZ inhibitor-2 (compound 5) (0-20000 nM; 24 h) shows antiproliferative activity with an IC₅₀ value of 5.33 nM in NCI-H226 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

YAP/TAZ inhibitor-2 (0.5, 2, 5, 50 mg/kg; p.o.; daily for 28 days) shows anti-tumor activity with no significant body weight loss during the treatment in BALB/c nude mice (NCI-H226 xenograft model)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Masse moléculaire

390.33

Formule

C₁₉H₁₄F₄N₄O

CAS No.

2762617-31-0

Appearance

Solid

Color

Light yellow to yellow

SMILES

C=C(F)C(N1CC(N2N=C(C3=CC=C(C(F)(F)F)C=C3)C4=CC=CN=C42)C1)=O

Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvant et solubilité

In Vitro:

DMSO : 100 mg/mL (256.19 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.5619 mL	12.8097 mL	25.6193 mL
5 mM	0.5124 mL	2.5619 mL	5.1239 mL
10 mM	0.2562 mL	1.2810 mL	2.5619 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculateur de molarité
Calculateur de dilution

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Pureté et documentation

Purity: 99.11%

Select Batch:

Fiche technique (273 KB) SDS (393 KB)

COA (250 KB) RP-HPLC (224 KB) MS (71 KB)

Instruction de manipulation (2659 KB)

Références

[1]. Xu, xiaofeng, et al. Bicyclic compounds, compositions and use thereof. WO2022037568A1.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.5619 mL	12.8097 mL	25.6193 mL	64.0484 mL
	5 mM	0.5124 mL	2.5619 mL	5.1239 mL	12.8097 mL
	10 mM	0.2562 mL	1.2810 mL	2.5619 mL	6.4048 mL
	15 mM	0.1708 mL	0.8540 mL	1.7080 mL	4.2699 mL
	20 mM	0.1281 mL	0.6405 mL	1.2810 mL	3.2024 mL
	25 mM	0.1025 mL	0.5124 mL	1.0248 mL	2.5619 mL
	30 mM	0.0854 mL	0.4270 mL	0.8540 mL	2.1349 mL
	40 mM	0.0640 mL	0.3202 mL	0.6405 mL	1.6012 mL
	50 mM	0.0512 mL	0.2562 mL	0.5124 mL	1.2810 mL
	60 mM	0.0427 mL	0.2135 mL	0.4270 mL	1.0675 mL
	80 mM	0.0320 mL	0.1601 mL	0.3202 mL	0.8006 mL
	100 mM	0.0256 mL	0.1281 mL	0.2562 mL	0.6405 mL